Konstantinos Douros1, Maria-Ioanna Thanopoulou2, Barbara Boutopoulou2, Anna Papadopoulou3, Anastassios Papadimitriou3, Andrew Fretzayas3, Kostas N Priftis2. 1. Children's Respiratory and Allergy Clinic, 3(rd) Dept of Paediatrics, National and Kapodistrian University of Athens, "Attikon" General University Hospital, Athens, Greece. Electronic address: costasdouros@gmail.com. 2. Children's Respiratory and Allergy Clinic, 3(rd) Dept of Paediatrics, National and Kapodistrian University of Athens, "Attikon" General University Hospital, Athens, Greece. 3. 3(rd) Dept of Paediatrics, National and Kapodistrian University of Athens, "Attikon" University Hospital, Athens, Greece.
Abstract
INTRODUCTION: There is accumulated evidence supporting a beneficial role of Mediterranean diet (MD) in the control of asthma symptoms. The aim of this study was to investigate the relationships between adherence to MD and serum levels of certain cytokines namely, interleukin (IL)-4, and IL-17 known to have a pathogenetic role in the airway changes associated with asthma. METHODS: We measured serum IL-4, IL-33, and IL-17, in 44 asthmatic and 26 healthy children, 5-15 years old. Their adherence to MD was estimated with the Mediterranean Diet Quality Index for children and adolescents (KIDMED) score. RESULTS: KIDMED score did not differ between the two groups (P=0.59) and was not correlated with any of the three measured cytokines. However, when the analysis was restricted only to asthmatic children, the KIDMED score was correlated with IL-4, IL-33, and IL-17 (Beta: -0.56, P=0.007; Beta: 0.57, P=0.010; Beta: -0.62, P=0.017, respectively). CONCLUSION: Our results indicate that MD can modulate the production of some of the main inflammatory mediators of asthma, in asthmatic children.
INTRODUCTION: There is accumulated evidence supporting a beneficial role of Mediterranean diet (MD) in the control of asthma symptoms. The aim of this study was to investigate the relationships between adherence to MD and serum levels of certain cytokines namely, interleukin (IL)-4, and IL-17 known to have a pathogenetic role in the airway changes associated with asthma. METHODS: We measured serum IL-4, IL-33, and IL-17, in 44 asthmatic and 26 healthy children, 5-15 years old. Their adherence to MD was estimated with the Mediterranean Diet Quality Index for children and adolescents (KIDMED) score. RESULTS: KIDMED score did not differ between the two groups (P=0.59) and was not correlated with any of the three measured cytokines. However, when the analysis was restricted only to asthmatic children, the KIDMED score was correlated with IL-4, IL-33, and IL-17 (Beta: -0.56, P=0.007; Beta: 0.57, P=0.010; Beta: -0.62, P=0.017, respectively). CONCLUSION: Our results indicate that MD can modulate the production of some of the main inflammatory mediators of asthma, in asthmatic children.
Authors: Melissa Bujtor; Anne I Turner; Susan J Torres; Laura Esteban-Gonzalo; Carmine M Pariante; Alessandra Borsini Journal: Nutrients Date: 2021-01-25 Impact factor: 5.717
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