Yavuz Gürkan1, Can Aksu2, Alparslan Kuş1, Ufuk H Yörükoğlu1, Cennet T Kılıç1. 1. Department of Anesthesiology and Reanimation, School of Medicine, Kocaeli University, Kocaeli, Turkey. 2. Department of Anesthesiology and Reanimation, School of Medicine, Kocaeli University, Kocaeli, Turkey. Electronic address: dr.aksu@gmail.com.
Abstract
STUDY OBJECTIVE: To evaluate the analgesic effect of ultrasound-guided erector spinae plane (ESP) block in breast cancer surgery. DESIGN: Randomized controlled, single-blinded trial. SETTING: Operating room. PATIENTS: Fifty ASA I-II patients aged 25-65 and scheduled for elective breast cancer surgery were included in the study. INTERVENTIONS: Patients were randomized into two groups, ESP and control. Single-shot ultrasound (US)-guided ESP block with 20 ml 0.25% bupivacaine at the T4 vertebral level was performed preoperatively to all patients in the ESP group. The control group received no intervention. Patients in both groups were provided with intravenous patient-controlled analgesia device containing morphine for postoperative analgesia. MEASUREMENTS: Morphine consumption and numeric rating scale (NRS) pain scores were recorded at 1, 6, 12 and 24 h postoperatively. MAIN RESULTS:Morphine consumption at postoperative hours 1, 6, 12 and 24 decreased significantly in the ESP group (p < 0.05 for each time interval). Total morphine consumption decreased by 65% at 24 h compared to the control group (5.76 ± 3.8 mg vs 16.6 ± 6.92 mg). There was no statistically significant difference between the groups in terms of NRS scores. CONCLUSIONS: Our study findings show that US-guided ESP block exhibits a significant analgesic effect in patients undergoing breast cancer surgery. Further studies comparing different regional anesthesia techniques are needed to identify the optimal analgesia technique for this group of patients.
RCT Entities:
STUDY OBJECTIVE: To evaluate the analgesic effect of ultrasound-guided erector spinae plane (ESP) block in breast cancer surgery. DESIGN: Randomized controlled, single-blinded trial. SETTING: Operating room. PATIENTS: Fifty ASA I-II patients aged 25-65 and scheduled for elective breast cancer surgery were included in the study. INTERVENTIONS:Patients were randomized into two groups, ESP and control. Single-shot ultrasound (US)-guided ESP block with 20 ml 0.25% bupivacaine at the T4 vertebral level was performed preoperatively to all patients in the ESP group. The control group received no intervention. Patients in both groups were provided with intravenous patient-controlled analgesia device containing morphine for postoperative analgesia. MEASUREMENTS: Morphine consumption and numeric rating scale (NRS) pain scores were recorded at 1, 6, 12 and 24 h postoperatively. MAIN RESULTS:Morphine consumption at postoperative hours 1, 6, 12 and 24 decreased significantly in the ESP group (p < 0.05 for each time interval). Total morphine consumption decreased by 65% at 24 h compared to the control group (5.76 ± 3.8 mg vs 16.6 ± 6.92 mg). There was no statistically significant difference between the groups in terms of NRS scores. CONCLUSIONS: Our study findings show that US-guided ESP block exhibits a significant analgesic effect in patients undergoing breast cancer surgery. Further studies comparing different regional anesthesia techniques are needed to identify the optimal analgesia technique for this group of patients.
Authors: Jacob C Cogan; Rohit R Raghunathan; Melissa P Beauchemin; Melissa K Accordino; Elena B Elkin; Alexander Melamed; Jason D Wright; Dawn L Hershman Journal: Breast Cancer Res Treat Date: 2021-06-04 Impact factor: 4.872