Literature DB >> 2997921

A new HTLV-III/LAV encoded antigen detected by antibodies from AIDS patients.

J S Allan, J E Coligan, T H Lee, M F McLane, P J Kanki, J E Groopman, M Essex.   

Abstract

A newly identified protein from HTLV-III/LAV, the virus implicated as the etiologic agent of the acquired immune deficiency syndrome, was studied. This protein, which has a molecular weight of 27,000 (p27), was shown by amino acid sequencing to have a coding origin 3' to the env gene on the HTLV-III genome. The presence of antibodies to p27 in virus-exposed individuals indicated that this gene is functional in the natural host.

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Year:  1985        PMID: 2997921     DOI: 10.1126/science.2997921

Source DB:  PubMed          Journal:  Science        ISSN: 0036-8075            Impact factor:   47.728


  53 in total

Review 1.  Acylation of viral and eukaryotic proteins.

Authors:  R J Grand
Journal:  Biochem J       Date:  1989-03-15       Impact factor: 3.857

2.  Mutational analysis of the human immunodeficiency virus: the orf-B region down-regulates virus replication.

Authors:  P A Luciw; C Cheng-Mayer; J A Levy
Journal:  Proc Natl Acad Sci U S A       Date:  1987-03       Impact factor: 11.205

3.  Differential response to the cytopathic effects of human T-cell lymphotropic virus type III (HTLV-III) superinfection in T4+ (helper) and T8+ (suppressor) T-cell clones transformed by HTLV-I.

Authors:  A De Rossi; G Franchini; A Aldovini; A Del Mistro; L Chieco-Bianchi; R C Gallo; F Wong-Staal
Journal:  Proc Natl Acad Sci U S A       Date:  1986-06       Impact factor: 11.205

4.  Expression and cellular localization of the Nef protein from human immunodeficiency virus-1 in stably transfected B-cells.

Authors:  N Kienzle; M Bachmann; W E Müller; N Müller-Lantzsch
Journal:  Arch Virol       Date:  1992       Impact factor: 2.574

5.  Induction of phosphorylation of human immunodeficiency virus type 1 Nef and enhancement of CD4 downregulation by phorbol myristate acetate.

Authors:  T Luo; J R Downing; J V Garcia
Journal:  J Virol       Date:  1997-03       Impact factor: 5.103

6.  Allelic variation in the effects of the nef gene on replication of human immunodeficiency virus type 1.

Authors:  E F Terwilliger; E Langhoff; D Gabuzda; E Zazopoulos; W A Haseltine
Journal:  Proc Natl Acad Sci U S A       Date:  1991-12-01       Impact factor: 11.205

7.  Specific cleavage sites of Nef proteins from human immunodeficiency virus types 1 and 2 for the viral proteases.

Authors:  J Schorr; R Kellner; O Fackler; J Freund; J Konvalinka; N Kienzle; H G Kräusslich; N Mueller-Lantzsch; H R Kalbitzer
Journal:  J Virol       Date:  1996-12       Impact factor: 5.103

8.  Human immunodeficiency virus type 1 Nef-induced down-modulation of CD4 is due to rapid internalization and degradation of surface CD4.

Authors:  S S Rhee; J W Marsh
Journal:  J Virol       Date:  1994-08       Impact factor: 5.103

Review 9.  The human immunodeficiency virus type 1 (HIV-1) CD4 receptor and its central role in promotion of HIV-1 infection.

Authors:  S Bour; R Geleziunas; M A Wainberg
Journal:  Microbiol Rev       Date:  1995-03

10.  Human immunodeficiency virus type 1 Nef associates with a cellular serine kinase in T lymphocytes.

Authors:  E T Sawai; A Baur; H Struble; B M Peterlin; J A Levy; C Cheng-Mayer
Journal:  Proc Natl Acad Sci U S A       Date:  1994-02-15       Impact factor: 11.205

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