T Amorim1,2, C Durães3,4, J C Machado3,4,5, G S Metsios6,7, M Wyon6, J Maia8, A D Flouris7, F Marques9, L Nogueira10, N Adubeiro10, Y Koutedakis6,7. 1. The Faculty of Education, Health and Wellbeing, University of Wolverhampton, Gorway Rd, Walsall, WS1 3BD, UK. tania_amorim@hotmail.com. 2. Centre of Research, Education, Innovation and Intervention in Sport, Faculty of Sports, University of Porto, Porto, Portugal. tania_amorim@hotmail.com. 3. i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal. 4. IPATIMUP-Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal. 5. Faculty of Medicine, University of Porto, Porto, Portugal. 6. The Faculty of Education, Health and Wellbeing, University of Wolverhampton, Gorway Rd, Walsall, WS1 3BD, UK. 7. FAME Laboratory, School of Sports and Exercise Sciences, University of Thessaly, Trikala, Greece. 8. Centre of Research, Education, Innovation and Intervention in Sport, Faculty of Sports, University of Porto, Porto, Portugal. 9. Faculty of Pharmacy, University of Porto, Porto, Portugal. 10. School of Health Technology of Porto, Polytechnic Institute of Porto, Porto, Portugal.
Abstract
The association of genetic polymorphisms with low bone mineral density in elite athletes have not been considered previously. The present study found that bone mass phenotypes in elite and pre-elite dancers are related to genetic variants at the Wnt/β-catenin and ER pathways. INTRODUCTION: Some athletes (e.g. gymnasts, dancers, swimmers) are at increased risk for low bone mineral density (BMD) which, if untreated, can lead to osteoporosis. To investigate the association of genetic polymorphisms in the oestrogen receptor (ER) and the Wnt/β-catenin signalling pathways with low BMD in elite and pre-elite dancers (impact sport athletes). METHODS: The study included three phases: (1) 151 elite and pre-elite dancers were screened for the presence of low BMD and traditional osteoporosis risk factors (low body weight, menstrual disturbances, low energy availability); (2) a genetic association study was conducted in 151 elite and pre-elite dancers and age- and sex- controls; (3) serum sclerostin was measured in 101 pre-elite dancers and age- and sex-matched controls within a 3-year period. RESULTS: Eighty dancers revealed low BMD: 56.3% had at least one traditional osteoporosis risk factor, whereas 28.6% did not display any risk factor (37.2% revealed traditional osteoporosis risk factors, but had normal BMD). Body weight, menstrual disturbances and energy availability did not fully predict bone mass acquisition. Instead, genetic polymorphisms in the ER and Wnt/β-catenin pathways were found to be risk factors for low BMD in elite dancers. Sclerostin was significantly increased in dancers compared to controls during the 3-year follow-up (p < 0.05). CONCLUSIONS: Elite and pre-elite dancers demonstrate high prevalence of low BMD, which is likely related to genetic variants at the Wnt/β-catenin and ER pathways and not to factors usually associated with BMD in athletes (body weight, menstrual disturbances, energy deficiency).
The association of genetic polymorphisms with low bone mineral density in elite athletes have not been considered previously. The present study found that bone mass phenotypes in elite and pre-elite dancers are related to genetic variants at the Wnt/β-catenin and ER pathways. INTRODUCTION: Some athletes (e.g. gymnasts, dancers, swimmers) are at increased risk for low bone mineral density (BMD) which, if untreated, can lead to osteoporosis. To investigate the association of genetic polymorphisms in the oestrogen receptor (ER) and the Wnt/β-catenin signalling pathways with low BMD in elite and pre-elite dancers (impact sport athletes). METHODS: The study included three phases: (1) 151 elite and pre-elite dancers were screened for the presence of low BMD and traditional osteoporosis risk factors (low body weight, menstrual disturbances, low energy availability); (2) a genetic association study was conducted in 151 elite and pre-elite dancers and age- and sex- controls; (3) serum sclerostin was measured in 101 pre-elite dancers and age- and sex-matched controls within a 3-year period. RESULTS: Eighty dancers revealed low BMD: 56.3% had at least one traditional osteoporosis risk factor, whereas 28.6% did not display any risk factor (37.2% revealed traditional osteoporosis risk factors, but had normal BMD). Body weight, menstrual disturbances and energy availability did not fully predict bone mass acquisition. Instead, genetic polymorphisms in the ER and Wnt/β-catenin pathways were found to be risk factors for low BMD in elite dancers. Sclerostin was significantly increased in dancers compared to controls during the 3-year follow-up (p < 0.05). CONCLUSIONS: Elite and pre-elite dancers demonstrate high prevalence of low BMD, which is likely related to genetic variants at the Wnt/β-catenin and ER pathways and not to factors usually associated with BMD in athletes (body weight, menstrual disturbances, energy deficiency).
Authors: L Maïmoun; O Coste; D Mariano-Goulart; F Galtier; T Mura; P Philibert; K Briot; F Paris; C Sultan Journal: Osteoporos Int Date: 2011-02-26 Impact factor: 4.507
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Authors: Tânia Amorim; George S Metsios; Matthew Wyon; Alan M Nevill; Andreas D Flouris; José Maia; Eduardo Teixeira; José Carlos Machado; Franklim Marques; Yiannis Koutedakis Journal: PLoS One Date: 2017-07-05 Impact factor: 3.240
Authors: Tânia Amorim; Laura Freitas; George S Metsios; Thayse Natacha Gomes; Matthew Wyon; Andreas D Flouris; José Maia; Franklim Marques; Luísa Nogueira; Nuno Adubeiro; Yiannis Koutedakis Journal: Arch Osteoporos Date: 2021-09-24 Impact factor: 2.617
Authors: A J Herbert; A G Williams; S J Lockey; R M Erskine; C Sale; P J Hennis; S H Day; G K Stebbings Journal: Eur J Appl Physiol Date: 2021-09-22 Impact factor: 3.078