M van der Thiel1,2, C Rodriguez3, P Giannakopoulos1,3, M X Burke4, R Marc Lebel4, N Gninenko1,2, D Van De Ville1,2, S Haller5,6,7. 1. From the Faculty of Medicine of the University of Geneva (M.v.d.T., P.G., N.G., D.v.d.V., S.H.), Geneva, Switzerland. 2. Institute of Bioengineering (M.v.d.T., N.G., D.v.d.V.), School of Engineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. 3. Division of Institutional Measures (C.R., P.G.), Medical Direction, University Hospitals of Geneva, Geneva, Switzerland. 4. GE Healthcare (M.X.B., M.L.), Little Chalfont, UK. 5. From the Faculty of Medicine of the University of Geneva (M.v.d.T., P.G., N.G., D.v.d.V., S.H.), Geneva, Switzerland sven.haller@gmail.com. 6. Affidea Centre de Diagnostic Radiologique de Carouge (S.H.), Geneva, Switzerland. 7. Department of Surgical Sciences and Radiology (S.H.), Uppsala University, Uppsala, Sweden.
Abstract
BACKGROUND AND PURPOSE: Multidelay arterial spin-labeling is a promising emerging method in clinical practice. The effect of imaging parameters in multidelay arterial spin-labeling on estimated cerebral blood flow measurements remains unknown. We directly compared 3-delay versus 7-delay sequences, assessing the difference in the estimated transit time and blood flow. MATERIALS AND METHODS: This study included 87 cognitively healthy controls (78.7 ± 3.8 years of age; 49 women). We assessed delay and transit time-uncorrected and transit time-corrected CBF maps. Data analysis included voxelwise permutation-based between-sequence comparisons of 3-delay versus 7-delay, within-sequence comparison of transit time-uncorrected versus transit time-corrected maps, and average CBF calculations in regions that have been shown to differ. RESULTS: The 7-delay sequence estimated a higher CBF value than the 3-delay for the transit time-uncorrected and transit time-corrected maps in regions corresponding to the watershed areas (transit time-uncorrected = 27.62 ± 12.23 versus 24.58 ± 11.70 mL/min/100 g, Cohen's d = 0.25; transit time-corrected = 33.48 ± 14.92 versus 30.16 ± 14.32 mL/min/100 g, Cohen's d = 0.23). In the peripheral regions of the brain, the estimated delay was found to be longer for the 3-delay sequence (1.52408 ± 0.25236 seconds versus 1.47755 ± 0.24242 seconds, Cohen's d = 0.19), while the inverse was found in the center of the brain (1.39388 ± 0.22056 seconds versus 1.42565 ± 0.21872 seconds, Cohen's d = 0.14). Moreover, 7-delay had lower hemispheric asymmetry. CONCLUSIONS: The results of this study support the necessity of standardizing acquisition parameters in multidelay arterial spin-labeling and identifying basic parameters as a confounding factor in CBF quantification studies. Our findings conclude that multidelay arterial spin-labeling sequences with a high number of delays estimate higher CBF values than those with a lower number of delays.
BACKGROUND AND PURPOSE: Multidelay arterial spin-labeling is a promising emerging method in clinical practice. The effect of imaging parameters in multidelay arterial spin-labeling on estimated cerebral blood flow measurements remains unknown. We directly compared 3-delay versus 7-delay sequences, assessing the difference in the estimated transit time and blood flow. MATERIALS AND METHODS: This study included 87 cognitively healthy controls (78.7 ± 3.8 years of age; 49 women). We assessed delay and transit time-uncorrected and transit time-corrected CBF maps. Data analysis included voxelwise permutation-based between-sequence comparisons of 3-delay versus 7-delay, within-sequence comparison of transit time-uncorrected versus transit time-corrected maps, and average CBF calculations in regions that have been shown to differ. RESULTS: The 7-delay sequence estimated a higher CBF value than the 3-delay for the transit time-uncorrected and transit time-corrected maps in regions corresponding to the watershed areas (transit time-uncorrected = 27.62 ± 12.23 versus 24.58 ± 11.70 mL/min/100 g, Cohen's d = 0.25; transit time-corrected = 33.48 ± 14.92 versus 30.16 ± 14.32 mL/min/100 g, Cohen's d = 0.23). In the peripheral regions of the brain, the estimated delay was found to be longer for the 3-delay sequence (1.52408 ± 0.25236 seconds versus 1.47755 ± 0.24242 seconds, Cohen's d = 0.19), while the inverse was found in the center of the brain (1.39388 ± 0.22056 seconds versus 1.42565 ± 0.21872 seconds, Cohen's d = 0.14). Moreover, 7-delay had lower hemispheric asymmetry. CONCLUSIONS: The results of this study support the necessity of standardizing acquisition parameters in multidelay arterial spin-labeling and identifying basic parameters as a confounding factor in CBF quantification studies. Our findings conclude that multidelay arterial spin-labeling sequences with a high number of delays estimate higher CBF values than those with a lower number of delays.
Authors: Sven Haller; Marie-Louise Montandon; Cristelle Rodriguez; Valentina Garibotto; Johan Lilja; François R Herrmann; Panteleimon Giannakopoulos Journal: Front Neurosci Date: 2019-11-15 Impact factor: 4.677
Authors: Merel van der Thiel; Cristelle Rodriguez; Dimitri Van De Ville; Panteleimon Giannakopoulos; Sven Haller Journal: Front Aging Neurosci Date: 2019-02-19 Impact factor: 5.750