Tingting Shi1, Min Min1, Chenyu Sun2, Yun Zhang1, Mingming Liang1, Yehuan Sun1,3. 1. Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China. 2. The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. 3. Center for Evidence-Based Practice, Anhui Medical University, Hefei, Anhui, China.
Abstract
OBJECTIVE: While some individual studies have suggested an association between periodontal disease and breast cancer, there has not been a formal meta-analysis that collates the existing evidence supporting the hypothesis that periodontal disease leads to a higher risk of developing breast cancer. Accordingly, this meta-analysis was conducted. METHODS: Relevant studies published until April 2018 were retrieved and were screened according to established inclusion criteria. Risk ratios (RRs) with 95% confidence intervals (CIs) were calculated to assess the association between periodontal disease and the risk of breast cancer and fixed effect models were used according to the results of the heterogeneity test. RESULTS: Eight studies, involving 168,111 individuals, were identified as having explored the association between periodontal disease and breast cancer. Summary estimates in view of adjusted data showed that periodontal disease did increase susceptibility to breast cancer (RR = 1.18, 95%CI: 1.11-1.26, I2 = 17.6%), with robust results confirmed by sensitivity analysis. CONCLUSION: Our results provided evidence of a modest positive association between periodontal disease and breast cancer. Implementation of practical measures to prevent and treat periodontal disease is of great public health significance. Moreover, additional studies are recommended to explore this topic in more detail.
OBJECTIVE: While some individual studies have suggested an association between periodontal disease and breast cancer, there has not been a formal meta-analysis that collates the existing evidence supporting the hypothesis that periodontal disease leads to a higher risk of developing breast cancer. Accordingly, this meta-analysis was conducted. METHODS: Relevant studies published until April 2018 were retrieved and were screened according to established inclusion criteria. Risk ratios (RRs) with 95% confidence intervals (CIs) were calculated to assess the association between periodontal disease and the risk of breast cancer and fixed effect models were used according to the results of the heterogeneity test. RESULTS: Eight studies, involving 168,111 individuals, were identified as having explored the association between periodontal disease and breast cancer. Summary estimates in view of adjusted data showed that periodontal disease did increase susceptibility to breast cancer (RR = 1.18, 95%CI: 1.11-1.26, I2 = 17.6%), with robust results confirmed by sensitivity analysis. CONCLUSION: Our results provided evidence of a modest positive association between periodontal disease and breast cancer. Implementation of practical measures to prevent and treat periodontal disease is of great public health significance. Moreover, additional studies are recommended to explore this topic in more detail.
Authors: Zeni Wu; Doratha A Byrd; Yunhu Wan; Daniel Ansong; Joe-Nat Clegg-Lamptey; Beatrice Wiafe-Addai; Lawrence Edusei; Ernest Adjei; Nicholas Titiloye; Florence Dedey; Francis Aitpillah; Joseph Oppong; Verna Vanderpuye; Ernest Osei-Bonsu; Casey L Dagnall; Kristine Jones; Amy Hutchinson; Belynda D Hicks; Thomas U Ahearn; Jianxin Shi; Rob Knight; Richard Biritwum; Joel Yarney; Seth Wiafe; Baffour Awuah; Kofi Nyarko; Jonine D Figueroa; Rashmi Sinha; Montserrat Garcia-Closas; Louise A Brinton; Emily Vogtmann Journal: Int J Cancer Date: 2022-06-30 Impact factor: 7.316
Authors: Mengmeng Jia; Zeni Wu; Emily Vogtmann; Katie M O'Brien; Clarice R Weinberg; Dale P Sandler; Gretchen L Gierach Journal: Cancer Prev Res (Phila) Date: 2020-07-29