| Literature DB >> 29973656 |
Chuan Tian1,2, Haixia Wu2, Chan Li3, Xia Tian2, Yong Sun4, Enqiang Liu5, Xiuyong Liao5, Wei Song6.
Abstract
The FoxM1 transcription factor plays an important role in the progression of HCC. Therefore, it is necessary to study cell regulation of FoxM1. In this study, we determined the expression of miR-214 and it was inversely associated with FoxM1 protein level in HCC; and suppression of FoxM1 translation by miR-214 mimics. We found that miR-214 targeted the 3'untranslated region of FoxM1 mRNA. In addition, the study found that DLX1 was the direct target of FoxM1 in HCC. Downregulation of FoxM1 inhibits the proliferation, migration, and invasion of HCC cells by miR-214. These results indicate that miR-214 may be used as a completely new molecular target by influencing FoxM1 expression in HCC.Entities:
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Year: 2018 PMID： 29973656 DOI： 10.1038/s41434-018-0029-4
Source DB: PubMed Journal: Gene Ther ISSN： 0969-7128 Impact factor: 5.250