Literature DB >> 29973648

The chemokine receptor CCR7 is a promising target for rheumatoid arthritis therapy.

Georgios L Moschovakis1, Anja Bubke2, Michaela Friedrichsen2, Jasmin Ristenpart2, Jaap Willem Back3, Christine S Falk4, Elisabeth Kremmer5,6, Reinhold Förster7.   

Abstract

The chemokine receptor CCR7 and its ligands CCL19 and CCL21 guide the homing and positioning of dendritic and T cells in lymphoid organs, thereby contributing to several aspects of adaptive immunity and immune tolerance. In the present study, we investigated the role of CCR7 in the pathogenesis of collagen-induced arthritis (CIA). By using a novel anti-human CCR7 antibody and humanized CCR7 mice, we evaluated CCR7 as a target in this autoimmune model of rheumatoid arthritis (RA). Ccr7-deficient mice were completely resistant to CIA and presented severely impaired antibody responses to collagen II (CII). Selective CCR7 expression on dendritic cells restored arthritis severity and anti-CII antibody titers. Prophylactic and therapeutic treatment of humanized CCR7 mice with anti-human CCR7 mAb 8H3-16A12 led to complete resistance to CIA and halted CIA progression, respectively. Our data demonstrate that CCR7 signaling is essential for the induction of CIA and identify CCR7 as a potential therapeutic target in RA.

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Year:  2018        PMID： 29973648      PMCID： PMC6804778          DOI： 10.1038/s41423-018-0056-5

Source DB:  PubMed          Journal:  Cell Mol Immunol        ISSN： 1672-7681            Impact factor:   11.530


  41 in total

1.  Generalized multi-organ autoimmunity in CCR7-deficient mice.

Authors:  Ana C M Davalos-Misslitz; Julia Rieckenberg; Stefanie Willenzon; Tim Worbs; Elisabeth Kremmer; Günter Bernhardt; Reinhold Förster
Journal:  Eur J Immunol       Date:  2007-03       Impact factor: 5.532

Review 2.  Therapeutic T-cell manipulation in rheumatoid arthritis: past, present and future.

Authors:  J D Isaacs
Journal:  Rheumatology (Oxford)       Date:  2008-05-25       Impact factor: 7.580

3.  Cutting edge: cure of colitis by CD4+CD25+ regulatory T cells.

Authors:  Christian Mottet; Holm H Uhlig; Fiona Powrie
Journal:  J Immunol       Date:  2003-04-15       Impact factor: 5.422

Review 4.  Chemokines and Chemokine Receptors in Lymphoid Tissue Dynamics.

Authors:  Olga Schulz; Swantje I Hammerschmidt; G Leandros Moschovakis; Reinhold Förster
Journal:  Annu Rev Immunol       Date:  2016-02-22       Impact factor: 28.527

Review 5.  Rheumatoid arthritis.

Authors:  Josef S Smolen; Daniel Aletaha; Iain B McInnes
Journal:  Lancet       Date:  2016-05-03       Impact factor: 79.321

6.  Characterization of CCL19 and CCL21 in rheumatoid arthritis.

Authors:  Sarah R Pickens; Nathan D Chamberlain; Michael V Volin; Richard M Pope; Arthur M Mandelin; Shiva Shahrara
Journal:  Arthritis Rheum       Date:  2011-04

7.  Lymph node T cell homeostasis relies on steady state homing of dendritic cells.

Authors:  Meike Wendland; Stefanie Willenzon; Jessica Kocks; Ana Clara Davalos-Misslitz; Swantje I Hammerschmidt; Kathrin Schumann; Elisabeth Kremmer; Michael Sixt; Angelika Hoffmeyer; Oliver Pabst; Reinhold Förster
Journal:  Immunity       Date:  2011-12-23       Impact factor: 31.745

8.  CXCR5- and CCR7-dependent lymphoid neogenesis in a murine model of chronic antigen-induced arthritis.

Authors:  Antje M Wengner; Uta E Höpken; Peter K Petrow; Sven Hartmann; Uta Schurigt; Rolf Bräuer; Martin Lipp
Journal:  Arthritis Rheum       Date:  2007-10

9.  Cutting edge: CD4+CD25+ regulatory T cells suppress antigen-specific autoreactive immune responses and central nervous system inflammation during active experimental autoimmune encephalomyelitis.

Authors:  Adam P Kohm; Pamela A Carpentier; Holly A Anger; Stephen D Miller
Journal:  J Immunol       Date:  2002-11-01       Impact factor: 5.422

10.  T cell specific Cxcr5 deficiency prevents rheumatoid arthritis.

Authors:  Georgios L Moschovakis; Anja Bubke; Michaela Friedrichsen; Christine S Falk; Regina Feederle; Reinhold Förster
Journal:  Sci Rep       Date:  2017-08-21       Impact factor: 4.379
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  16 in total

Review 1.  Does CCL19 act as a double-edged sword in cancer development?

Authors:  Arezoo Gowhari Shabgah; Zaid Mahdi Jaber Al-Obaidi; Heshu Sulaiman Rahman; Walid Kamal Abdelbasset; Wanich Suksatan; Dmitry O Bokov; Lakshmi Thangavelu; Abduladheem Turki Jalil; Farhad Jadidi-Niaragh; Hamed Mohammadi; Kazem Mashayekhi; Jamshid Gholizadeh Navashenaq
Journal:  Clin Exp Immunol       Date:  2022-04-04       Impact factor: 4.330

Review 2.  Chemokines in rheumatic diseases: pathogenic role and therapeutic implications.

Authors:  Yoshishige Miyabe; Jeffrey Lian; Chie Miyabe; Andrew D Luster
Journal:  Nat Rev Rheumatol       Date:  2019-11-08       Impact factor: 20.543

Review 3.  Promising Therapeutic Targets for Treatment of Rheumatoid Arthritis.

Authors:  Jie Huang; Xuekun Fu; Xinxin Chen; Zheng Li; Yuhong Huang; Chao Liang
Journal:  Front Immunol       Date:  2021-07-09       Impact factor: 7.561

4.  The Secretome Derived From 3D-Cultured Umbilical Cord Tissue MSCs Counteracts Manifestations Typifying Rheumatoid Arthritis.

Authors:  Joana P Miranda; Sérgio P Camões; Maria M Gaspar; Joana S Rodrigues; Manuela Carvalheiro; Rita N Bárcia; Pedro Cruz; Helder Cruz; Sandra Simões; Jorge M Santos
Journal:  Front Immunol       Date:  2019-02-05       Impact factor: 7.561

5.  Structural Basis for Allosteric Ligand Recognition in the Human CC Chemokine Receptor 7.

Authors:  Kathrin Jaeger; Steffen Bruenle; Tobias Weinert; Wolfgang Guba; Jonas Muehle; Takuya Miyazaki; Martin Weber; Antonia Furrer; Noemi Haenggi; Tim Tetaz; Chia-Ying Huang; Daniel Mattle; Jean-Marie Vonach; Alain Gast; Andreas Kuglstatter; Markus G Rudolph; Przemyslaw Nogly; Joerg Benz; Roger J P Dawson; Joerg Standfuss
Journal:  Cell       Date:  2019-08-22       Impact factor: 41.582

6.  The Cancer Genome Atlas dataset-based analysis of aberrantly expressed genes by GeneAnalytics in thymoma associated myasthenia gravis: focusing on T cells.

Authors:  Jianying Xi; Liang Wang; Chong Yan; Jie Song; Yang Song; Ji Chen; Yongjun Zhu; Zhiming Chen; Chun Jin; Jianyong Ding; Chongbo Zhao
Journal:  J Thorac Dis       Date:  2019-06       Impact factor: 2.895

7.  CD3+CD4+gp130+ T Cells Are Associated With Worse Disease Activity in Systemic Lupus Erythematosus Patients.

Authors:  Nur Diyana Mohd Shukri; Aziz Farah Izati; Wan Syamimee Wan Ghazali; Che Maraina Che Hussin; Kah Keng Wong
Journal:  Front Immunol       Date:  2021-06-04       Impact factor: 7.561

Review 8.  Dendritic cell migration in inflammation and immunity.

Authors:  Juan Liu; Xiaomin Zhang; Yujie Cheng; Xuetao Cao
Journal:  Cell Mol Immunol       Date:  2021-07-23       Impact factor: 11.530

9.  T cell-intrinsic role for Nod2 in protection against Th17-mediated uveitis.

Authors:  Ruth J Napier; Ellen J Lee; Michael P Davey; Emily E Vance; João M Furtado; Paige E Snow; Kimberly A Samson; Sydney J Lashley; Brieanna R Brown; Reiko Horai; Mary J Mattapallil; Biying Xu; Michelle C Callegan; Luke S Uebelhoer; Christina L Lancioni; Richard K Vehe; Bryce A Binstadt; Justine R Smith; Rachel R Caspi; Holly L Rosenzweig
Journal:  Nat Commun       Date:  2020-10-26       Impact factor: 14.919

10.  Accumulation of synovial fluid CD19+CD24hiCD27+ B cells was associated with bone destruction in rheumatoid arthritis.

Authors:  Xiaofeng Guo; Tingting Xu; Jing Zheng; Xiangjun Cui; Ming Li; Kai Wang; Min Su; Huifang Zhang; Ke Zheng; Chongling Sun; Shulin Song; Hongjiang Liu
Journal:  Sci Rep       Date:  2020-09-01       Impact factor: 4.379
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