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Literature DB >> 29972801

Modeling the Hidden Pathways of IKs Channel Activation.

David Fedida¹.

Abstract

Mesh：

Substances：

Year: 2018 PMID： 29972801 PMCID： PMC6037128 DOI： 10.1016/j.bpj.2018.05.020

Source DB: PubMed Journal: Biophys J ISSN： 0006-3495 Impact factor: 4.033

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17 in total

1. How does KCNE1 regulate the Kv7.1 potassium channel? Model-structure, mutations, and dynamics of the Kv7.1-KCNE1 complex.

Authors: Yana Gofman; Simona Shats; Bernard Attali; Turkan Haliloglu; Nir Ben-Tal
Journal: Structure Date: 2012-07-05 Impact factor: 5.006

2. KCNE1 alters the voltage sensor movements necessary to open the KCNQ1 channel gate.

Authors: Jeremiah D Osteen; Carlos Gonzalez; Kevin J Sampson; Vivek Iyer; Santiago Rebolledo; H Peter Larsson; Robert S Kass
Journal: Proc Natl Acad Sci U S A Date: 2010-12-13 Impact factor: 11.205

3. Structural models for the KCNQ1 voltage-gated potassium channel.

Authors: Jarrod A Smith; Carlos G Vanoye; Alfred L George; Jens Meiler; Charles R Sanders
Journal: Biochemistry Date: 2007-11-14 Impact factor: 3.162

4. KCNQ1 channels do not undergo concerted but sequential gating transitions in both the absence and the presence of KCNE1 protein.

Authors: Eshcar Meisel; Meidan Dvir; Yoni Haitin; Moshe Giladi; Asher Peretz; Bernard Attali
Journal: J Biol Chem Date: 2012-08-20 Impact factor: 5.157

10. Unnatural amino acid photo-crosslinking of the IKs channel complex demonstrates a KCNE1:KCNQ1 stoichiometry of up to 4:4.

Authors: Christopher I Murray; Maartje Westhoff; Jodene Eldstrom; Emely Thompson; Robert Emes; David Fedida
Journal: Elife Date: 2016-01-23 Impact factor: 8.140

Modeling the Hidden Pathways of IKs Channel Activation.

1. How does KCNE1 regulate the Kv7.1 potassium channel? Model-structure, mutations, and dynamics of the Kv7.1-KCNE1 complex.

2. KCNE1 alters the voltage sensor movements necessary to open the KCNQ1 channel gate.

3. Structural models for the KCNQ1 voltage-gated potassium channel.

4. KCNQ1 channels do not undergo concerted but sequential gating transitions in both the absence and the presence of KCNE1 protein.

Review 5. The KCNQ1 channel - remarkable flexibility in gating allows for functional versatility.

6. Mechanistic basis for LQT1 caused by S3 mutations in the KCNQ1 subunit of IKs.

7. Structure of KCNE1 and implications for how it modulates the KCNQ1 potassium channel.

8. Cryo-EM Structure of a KCNQ1/CaM Complex Reveals Insights into Congenital Long QT Syndrome.

9. Inactivation of KCNQ1 potassium channels reveals dynamic coupling between voltage sensing and pore opening.

10. Unnatural amino acid photo-crosslinking of the IKs channel complex demonstrates a KCNE1:KCNQ1 stoichiometry of up to 4:4.