José L Carrasco-Juan1, Hugo Álvarez-Argüelles-Cabrera2,3, Carmen Martín-Corriente3, Ricardo Gutiérrez-García2, Abián Vega-Falcón3, Idaira Expósito-Afonso3, Rafael Méndez-Medina2,3, Lucio Díaz-Flores2. 1. Department of Basic Medical Sciences, Faculty of Health Sciences, Medicine Section, University of La Laguna, C/Sta. María Soledad, s/n. Apartado 456, Código Postal 38200, San Cristóbal de La Laguna, Tenerife, Islas Canarias, Spain. jcarraju@ull.edu.es. 2. Department of Basic Medical Sciences, Faculty of Health Sciences, Medicine Section, University of La Laguna, C/Sta. María Soledad, s/n. Apartado 456, Código Postal 38200, San Cristóbal de La Laguna, Tenerife, Islas Canarias, Spain. 3. Service of Pathology, Canary University Hospital Complex, Tenerife, Spain.
Abstract
PURPOSE: We are conducting a prospective study trying to determine, in both sexes, the frequency of appearance of ectopic Leydig cells, their preferred location, their relationship with nerve structures and the possible causes of their appearance. METHODS: We have studied 86 cases that were removed according to different clinical indications for pathological study: uterine leyomiomas (n = 12), ovarian cystadenoma (n = 4), endometrial hyperplasia (n = 8), endometrial carcinoma (n = 12), cervical carcinoma (n = 4), seminoma (n = 4), fallopian tube ligatures (n = 24), vasectomies (n = 8), nonspecific orchiepididymitis (n = 2), and unknown (n = 8). RESULTS: We have observed ectopic Leydig cells in 13/86 cases (15.11%), 9/72 in the female samples (12.50%) and 4/14 in male samples (28.57%). The most frequent location was the mesosalpinx (4 of 13: 30.76%). CONCLUSIONS: These high figures lead us to believe that the ectopia of Leydig cells is not really a pathologic entity, but a finding related to specific functions yet to be determined.
PURPOSE: We are conducting a prospective study trying to determine, in both sexes, the frequency of appearance of ectopic Leydig cells, their preferred location, their relationship with nerve structures and the possible causes of their appearance. METHODS: We have studied 86 cases that were removed according to different clinical indications for pathological study: uterine leyomiomas (n = 12), ovarian cystadenoma (n = 4), endometrial hyperplasia (n = 8), endometrial carcinoma (n = 12), cervical carcinoma (n = 4), seminoma (n = 4), fallopian tube ligatures (n = 24), vasectomies (n = 8), nonspecific orchiepididymitis (n = 2), and unknown (n = 8). RESULTS: We have observed ectopic Leydig cells in 13/86 cases (15.11%), 9/72 in the female samples (12.50%) and 4/14 in male samples (28.57%). The most frequent location was the mesosalpinx (4 of 13: 30.76%). CONCLUSIONS: These high figures lead us to believe that the ectopia of Leydig cells is not really a pathologic entity, but a finding related to specific functions yet to be determined.