Yongjiang Li1, Wenbiao Zhang2, Shuangjiang Li2, Chongqi Tu1. 1. Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, China. 2. Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
Abstract
INTRODUCTION: Recurrent pulmonary metastasis is common in sarcoma patients following the first pulmonary metastasectomy. Repeated pulmonary metastasectomy (RPM) may be a possible treatment method, but it has several unfavorable aspects. The clinical efficiency of RPM has not been established, as previous studies have reached inconsistent results. MATERIALS AND METHODS: Comprehensively literature searches were conducted in PubMed, Web of Science, Embase, and Cochrane Library. All eligible articles were included according to inclusion criteria. Then, a meta-analysis was conducted to clarify the clinical efficiency of RPM. RESULTS: A total of 9 articles with 464 patients were included. We found that sarcoma patients with recurrent pulmonary metastasis that underwent RPM had significantly better overall survival (hazard ratio = 0.59; 95% confidence interval, 0.44-0.81; P = 0.001). No significant publication bias was found. Sensitivity analysis showed the results were stable. CONCLUSION: Selected sarcoma patients with recurrent pulmonary metastasis following the first pulmonary metastasectomy could still benefit from RPM, despite its unfavorable aspects.
INTRODUCTION: Recurrent pulmonary metastasis is common in sarcoma patients following the first pulmonary metastasectomy. Repeated pulmonary metastasectomy (RPM) may be a possible treatment method, but it has several unfavorable aspects. The clinical efficiency of RPM has not been established, as previous studies have reached inconsistent results. MATERIALS AND METHODS: Comprehensively literature searches were conducted in PubMed, Web of Science, Embase, and Cochrane Library. All eligible articles were included according to inclusion criteria. Then, a meta-analysis was conducted to clarify the clinical efficiency of RPM. RESULTS: A total of 9 articles with 464 patients were included. We found that sarcoma patients with recurrent pulmonary metastasis that underwent RPM had significantly better overall survival (hazard ratio = 0.59; 95% confidence interval, 0.44-0.81; P = 0.001). No significant publication bias was found. Sensitivity analysis showed the results were stable. CONCLUSION: Selected sarcoma patients with recurrent pulmonary metastasis following the first pulmonary metastasectomy could still benefit from RPM, despite its unfavorable aspects.
Authors: Mustafa Abugideiri; James Janopaul-Naylor; Jeffrey Switchenko; Sibo Tian; William Read; Robert Press; Shervin Oskouei; Nickolas Reimer; Matthew Ferris; Richard J Cassidy; Madhusmita Behera; David Monson; Jerome Landry; Karen D Godette; Pretesh R Patel Journal: Ann Surg Oncol Date: 2021-07-16 Impact factor: 5.344