G Bathla1, P Watal2, S Gupta3, N Soni2, A A Capizzano2, C P Derdeyn2, T Moritani4. 1. Division of Neuroradiology, Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA. Electronic address: girish-bathla@uiowa.edu. 2. Division of Neuroradiology, Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA. 3. Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA. 4. Division of Neuroradiology, Michigan Radiology, University of Michigan, Ann Arbor, MI, USA.
Abstract
AIM: To determine the occurrence of ischaemic and haemorrhagic events in patients with neurosarcoidosis at presentation and follow-up and to evaluate its association with perivascular enhancement. MATERIALS AND METHODS: The MRI findings in patients with neurosarcoidosis who presented to our institute from 2002-2017 were retrospectively reviewed, with emphasis on cerebrovascular events. A chi-squared test was used to evaluate the statistical association with presence of perivascular enhancement. RESULTS: A total of 49 patients (32 females and 17 males) were analysed. Ischaemic events were noted in four patients at presentation while parenchymal haemorrhages occurred in three patients. The combined occurrence of cerebrovascular events (CVEs) at presentation was 14%. On follow-up, three additional patients developed ischaemic infarcts, of which, one patient had parenchymal haemorrhage at presentation. Additionally, one patient also developed new parenchymal haemorrhages. In total, 10 patients in current cohort developed CVEs, either at presentation or on follow-up. Perivascular enhancement was seen in 50% of patients with cerebrovascular events and 18% of patients with neurosarcoidosis, but no CVEs. This was statistically significant (p<0.05). CONCLUSION: CVEs in patients with neurosarcoidosis are more common than previously reported and appear to be significantly related to the presence of perivascular enhancement on imaging. Published by Elsevier Ltd.
AIM: To determine the occurrence of ischaemic and haemorrhagic events in patients with neurosarcoidosis at presentation and follow-up and to evaluate its association with perivascular enhancement. MATERIALS AND METHODS: The MRI findings in patients with neurosarcoidosis who presented to our institute from 2002-2017 were retrospectively reviewed, with emphasis on cerebrovascular events. A chi-squared test was used to evaluate the statistical association with presence of perivascular enhancement. RESULTS: A total of 49 patients (32 females and 17 males) were analysed. Ischaemic events were noted in four patients at presentation while parenchymal haemorrhages occurred in three patients. The combined occurrence of cerebrovascular events (CVEs) at presentation was 14%. On follow-up, three additional patients developed ischaemic infarcts, of which, one patient had parenchymal haemorrhage at presentation. Additionally, one patient also developed new parenchymal haemorrhages. In total, 10 patients in current cohort developed CVEs, either at presentation or on follow-up. Perivascular enhancement was seen in 50% of patients with cerebrovascular events and 18% of patients with neurosarcoidosis, but no CVEs. This was statistically significant (p<0.05). CONCLUSION: CVEs in patients with neurosarcoidosis are more common than previously reported and appear to be significantly related to the presence of perivascular enhancement on imaging. Published by Elsevier Ltd.
Authors: Joseph C J Bot; Linda Mazzai; Rogier E Hagenbeek; Silvia Ingala; Bob van Oosten; Esther Sanchez-Aliaga; Frederik Barkhof Journal: Neuroradiology Date: 2020-01-10 Impact factor: 2.804
Authors: Amit Mehta; Fahad Khan; Chris Wagner; Taymour Hashemzadeh; Andrew Stemer; Emily A Sloan; Douglas Mayson; Faria Amjad Journal: Neurohospitalist Date: 2021-06-30
Authors: Girish Bathla; Lama Abdel-Wahed; Amit Agarwal; Tracey A Cho; Sarika Gupta; Karra A Jones; Sarv Priya; Neetu Soni; Bruce A Wasserman Journal: Neurol Neuroimmunol Neuroinflamm Date: 2021-08-04