Philipe de Souto Barreto1, Yves Rolland2, Mathieu Maltais3, Bruno Vellas2. 1. Gérontopôle de Toulouse, Institut du Vieillissement, Centre Hospitalo-Universitaire de Toulouse, France; Unité Mixte de Recherche (UMR) Institut National de la Santé et de la recherche médicale (INSERM) 1027, University of Toulouse III, France. Electronic address: philipebarreto81@yahoo.com.br. 2. Gérontopôle de Toulouse, Institut du Vieillissement, Centre Hospitalo-Universitaire de Toulouse, France; Unité Mixte de Recherche (UMR) Institut National de la Santé et de la recherche médicale (INSERM) 1027, University of Toulouse III, France. 3. Gérontopôle de Toulouse, Institut du Vieillissement, Centre Hospitalo-Universitaire de Toulouse, France.
Abstract
BACKGROUND: The objective of this study was to investigate whether a long-term multidomain lifestyle intervention was associated with the severity and incidence of frailty in older adults. METHODS: A 3-year randomized controlled trial was conducted among 1637 French community dwellers age ≥70: 821 controls and 816 who received amultidomain lifestyle intervention (cognitive training, nutrition counseling, and advice on physical activity). The intervention involved 12 2-hour sessions (in the first 2 months) followed by a 1-hour session each month until the study end. Controls received the usual care but did not receive any personalized lifestyle intervention. A frailty index (FI; range = 0-1, higher is worse) composed of 32 items was calculated at baseline, 6 months, 1 year, 2 years, and 3 years and constituted our main endpoint. FI ≥ 0.25 defined frailty. The 4 outcomes were severity of frailty (continuous FI score), incident frailty, incidence of persistent frailty (frailty at 2 consecutive time points), and reversibility of frailty (from frailty to nonfrailty). RESULTS: Mixed-effect linear regression did not find a significant effect of the multidomain intervention on FI score. Frailty incidence occurred in 241 of 1146 subjects (138 controls and 103 in the multidomain group), whereas incidence of persistent frailty occurred in 75 of 1042 subjects (48 controls and 27 in the multidomain group). Cox models adjusted for baseline FI scores showed that compared with controls, subjects in the multidomain group had a decreased risk of developing both frailty (hazard ratio 0.72; 95% confidence interval, 0.55-0.93) and persistent frailty (hazard ratio 0.53; 95% confidence interval, 0.33-0.85). CONCLUSIONS: This multidomain lifestyle intervention was associated with a reduced risk of developing frailty but did not affect the severity of frailty in community-dwelling older adults.
RCT Entities:
BACKGROUND: The objective of this study was to investigate whether a long-term multidomain lifestyle intervention was associated with the severity and incidence of frailty in older adults. METHODS: A 3-year randomized controlled trial was conducted among 1637 French community dwellers age ≥70: 821 controls and 816 who received a multidomain lifestyle intervention (cognitive training, nutrition counseling, and advice on physical activity). The intervention involved 12 2-hour sessions (in the first 2 months) followed by a 1-hour session each month until the study end. Controls received the usual care but did not receive any personalized lifestyle intervention. A frailty index (FI; range = 0-1, higher is worse) composed of 32 items was calculated at baseline, 6 months, 1 year, 2 years, and 3 years and constituted our main endpoint. FI ≥ 0.25 defined frailty. The 4 outcomes were severity of frailty (continuous FI score), incident frailty, incidence of persistent frailty (frailty at 2 consecutive time points), and reversibility of frailty (from frailty to nonfrailty). RESULTS: Mixed-effect linear regression did not find a significant effect of the multidomain intervention on FI score. Frailty incidence occurred in 241 of 1146 subjects (138 controls and 103 in the multidomain group), whereas incidence of persistent frailty occurred in 75 of 1042 subjects (48 controls and 27 in the multidomain group). Cox models adjusted for baseline FI scores showed that compared with controls, subjects in the multidomain group had a decreased risk of developing both frailty (hazard ratio 0.72; 95% confidence interval, 0.55-0.93) and persistent frailty (hazard ratio 0.53; 95% confidence interval, 0.33-0.85). CONCLUSIONS: This multidomain lifestyle intervention was associated with a reduced risk of developing frailty but did not affect the severity of frailty in community-dwelling older adults.
Authors: Olga Theou; Alexandra M van der Valk; Judith Godin; Melissa K Andrew; Janet E McElhaney; Shelly A McNeil; Kenneth Rockwood Journal: J Gerontol A Biol Sci Med Sci Date: 2020-09-25 Impact factor: 6.053
Authors: Felicia R Simpson; Nicholas M Pajewski; Barbara Nicklas; Stephen Kritchevsky; Alain Bertoni; Frank Ingram; Daniel Ojeranti; Mark A Espeland Journal: J Gerontol A Biol Sci Med Sci Date: 2020-09-25 Impact factor: 6.053
Authors: Stephen H-F Macdonald; John Travers; Éidín Ní Shé; Jade Bailey; Roman Romero-Ortuno; Michael Keyes; Diarmuid O'Shea; Marie Therese Cooney Journal: PLoS One Date: 2020-02-07 Impact factor: 3.240
Authors: Roberta Bevilacqua; Luca Soraci; Vera Stara; Giovanni Renato Riccardi; Andrea Corsonello; Giuseppe Pelliccioni; Fabrizia Lattanzio; Sara Casaccia; Johanna Möller; Rainer Wieching; Toshimi Ogawa; Suichiro Watanabe; Keisuke Kokobun; Izumi Kondo; Eiko Takano; Elvira Maranesi Journal: Front Med (Lausanne) Date: 2022-07-15