Literature DB >> 29968537

Polyploid Giant Cancer Cells (PGCCs): The Evil Roots of Cancer.

Junsong Chen1,2, Na Niu2, Jing Zhang3, Lisha Qi2,4, Weiwei Shen2,5, Krishna Vanaja Donkena2, Zhenqing Feng1, Jinsong Liu2.   

Abstract

Polyploidy is associated with increased cell size and is commonly found in a subset of adult organs and blastomere stage of the human embryo. The polyploidy is formed through endoreplication or cell fusion to support the specific need of development including earliest embryogenesis. Recent data demonstrated that Polyploid Giant Cancer Cells (PGCCs) may have acquired an activated early embryonic-like program in response to oncogenic and therapeutic stress to generate reprogrammed cancer cells for drug resistance and metastasis. Targeting PGCCs may open up new opportunities for cancer therapy. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

Entities:  

Keywords:  Polyploid giant cancer cells; blastomere-like cancer stem cells; cancer stem cells; cell fusion; endoreplication; reprogramming.

Year:  2019        PMID： 29968537     DOI： 10.2174/1568009618666180703154233

Source DB:  PubMed          Journal:  Curr Cancer Drug Targets        ISSN： 1568-0096            Impact factor:   3.428


  42 in total

Review 1.  Polyploidy: A Biological Force From Cells to Ecosystems.

Authors:  Donald T Fox; Douglas E Soltis; Pamela S Soltis; Tia-Lynn Ashman; Yves Van de Peer
Journal:  Trends Cell Biol       Date:  2020-07-06       Impact factor: 20.808

2.  Differential detachment of intact and viable cells of different sizes using laser-induced microbubbles.

Authors:  Wanyoung Lim; Seungjin Lee; Sungsu Park; Hyoung Won Baac
Journal:  Biomed Opt Express       Date:  2019-09-04       Impact factor: 3.732

3.  Polypoidal giant cancer cells in metastatic castration-resistant prostate cancer: observations from the Michigan Legacy Tissue Program.

Authors:  Rahul Mannan; Xiaoming Wang; Pushpinder S Bawa; Daniel E Spratt; Allecia Wilson; Jeffrey Jentzen; Arul M Chinnaiyan; Zachery R Reichert; Rohit Mehra
Journal:  Med Oncol       Date:  2020-02-06       Impact factor: 3.064

Review 4.  Giants and monsters: Unexpected characters in the story of cancer recurrence.

Authors:  Shai White-Gilbertson; Christina Voelkel-Johnson
Journal:  Adv Cancer Res       Date:  2020-05-04       Impact factor: 6.242

Review 5.  The life cycle of polyploid giant cancer cells and dormancy in cancer: Opportunities for novel therapeutic interventions.

Authors:  Jinsong Liu; Na Niu; Xiaoran Li; Xudong Zhang; Anil K Sood
Journal:  Semin Cancer Biol       Date:  2021-10-17       Impact factor: 15.707

Review 6.  Polyploidy in development and tumor models in Drosophila.

Authors:  Caique Almeida Machado Costa; Xian-Feng Wang; Calder Ellsworth; Wu-Min Deng
Journal:  Semin Cancer Biol       Date:  2021-09-22       Impact factor: 17.012

Review 7.  Polyploid giant cancer cells: Unrecognized actuators of tumorigenesis, metastasis, and resistance.

Authors:  Sarah R Amend; Gonzalo Torga; Ke-Chih Lin; Laurie G Kostecka; Angelo de Marzo; Robert H Austin; Kenneth J Pienta
Journal:  Prostate       Date:  2019-08-02       Impact factor: 4.104

Review 8.  Convergent Evolution, Evolving Evolvability, and the Origins of Lethal Cancer.

Authors:  Kenneth J Pienta; Emma U Hammarlund; Robert Axelrod; Sarah R Amend; Joel S Brown
Journal:  Mol Cancer Res       Date:  2020-03-31       Impact factor: 5.852

9.  Loss of Aurora Kinase Signaling Allows Lung Cancer Cells to Adopt Endoreplication and Form Polyploid Giant Cancer Cells That Resist Antimitotic Drugs.

Authors:  Vural Tagal; Michael G Roth
Journal:  Cancer Res       Date:  2020-11-10       Impact factor: 12.701

10.  Polyploid mitosis and depolyploidization promote chromosomal instability and tumor progression in a Notch-induced tumor model.

Authors:  Xian-Feng Wang; Sheng-An Yang; Shangyu Gong; Chih-Hsuan Chang; Juan Martin Portilla; Deeptiman Chatterjee; Jerome Irianto; Hongcun Bao; Yi-Chun Huang; Wu-Min Deng
Journal:  Dev Cell       Date:  2021-06-18       Impact factor: 13.417
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