| Literature DB >> 29968482 |
Boddu Rama Krishna1,2, Sistla Ramakrishna2,3, Sangaraju Rajendra2,3, Kuncha Madhusudana3, Uppuluri Venkata Mallavadhani1,2.
Abstract
Sixteen novel orsellinic esters (6a-l, 7a-d) along with four lecanoric acid related depsides (3a-c, 4) were synthesized and confirmed their structures by spectroscopic data (1H, 13C & HRMS). The synthesized compounds were evaluated for their in vitro α-glucosidase (Saccharomyces cerevisiae) inhibitory potential. Among the tested compounds, 3c (IC50: 140.9 μM) and 6c (IC50: 203.9 μM) displayed potent α-glucosidase inhibitory activity and found more active than the standard drug acarbose (IC50: 686.6 μM). Both the test compounds were subjected to in vivo antihyperglycemic activity using sucrose loaded model in Wistar rats and found compound 3c exhibited significant reduction in glucose levels.Entities:
Keywords: -glucosidase inhibitors; Lecanoric acid depsides; anti hyperglycemic activity; new orsellinic esters
Mesh：
Substances：
Year: 2018 PMID： 29968482 DOI： 10.1080/10286020.2018.1490274
Source DB: PubMed Journal: J Asian Nat Prod Res ISSN： 1028-6020 Impact factor: 1.569