Literature DB >> 29967970

Prognostic Potential of the Panfungal Marker (1 → 3)-β-D-Glucan in Invasive Mycoses Patients.

P Pini1,2, C Venturelli2, M Girardis2, F Forghieri2, E Blasi3,4.   

Abstract

We analyze the prognostic potential of (1 → 3)-β-D-glucan (BG) levels in predicting clinical outcomes in patients with invasive fungal infections, on a population undergoing 253 episodes (177 with positive and 76 with negative outcome). Using linear regression analysis, we assessed the prognostic potential of kinetically evaluated BG levels and we found an overall sensitivity and specificity of 68 and 82%, respectively. Moreover, using an interpretative algorithm based on two distinct cutoff values, we were able to predict the outcome in 84% of the studied population with a diagnostic accuracy of 82%.

Entities:  

Keywords:  Beta glucan; Invasive fungal infections; Panfungal marker; Prognostic evaluation

Mesh：

Substances：

Year:  2018        PMID： 29967970     DOI： 10.1007/s11046-018-0282-5

Source DB:  PubMed          Journal:  Mycopathologia        ISSN： 0301-486X            Impact factor:   2.574


  8 in total

1.  Evaluation of serum (1 → 3)-β-D-glucan clinical performance: kinetic assessment, comparison with galactomannan and evaluation of confounding factors.

Authors:  P Pini; C Bettua; C F Orsi; C Venturelli; F Forghieri; S Bigliardi; L Faglioni; F Luppi; L Serio; M Codeluppi; M Luppi; C Mussini; M Girardis; Elisabetta Blasi
Journal:  Infection       Date:  2015-10-16       Impact factor: 3.553

2.  Assessment of serum (1->3)-beta-D-glucan concentration as a measure of disease burden in a murine model of invasive pulmonary aspergillosis.

Authors:  Nathan P Wiederhold; Laura K Najvar; Ana C Vallor; William R Kirkpatrick; Rosie Bocanegra; Destiny Molina; Marcos Olivo; John R Graybill; Thomas F Patterson
Journal:  Antimicrob Agents Chemother       Date:  2007-12-26       Impact factor: 5.191

3.  A prospective study of fungal biomarkers to improve management of invasive fungal diseases in a mixed specialty critical care unit.

Authors:  Alida Fe Talento; Katie Dunne; Eimear Ann Joyce; Michael Palmer; Elizabeth Johnson; P Lewis White; Jan Springer; Juergen Loeffler; Thomas Ryan; Daniel Collins; Thomas R Rogers
Journal:  J Crit Care       Date:  2017-03-30       Impact factor: 3.425

4.  Correlation of clinical outcomes with β-glucan levels in patients with invasive candidiasis.

Authors:  Charles R Sims; Siraya Jaijakul; John Mohr; Jose Rodriguez; Malcolm Finkelman; Luis Ostrosky-Zeichner
Journal:  J Clin Microbiol       Date:  2012-03-29       Impact factor: 5.948

5.  Characterization of a distinct host response profile to Pneumocystis murina asci during clearance of pneumocystis pneumonia.

Authors:  Michael J Linke; Alan Ashbaugh; Margaret S Collins; Keeley Lynch; Melanie T Cushion
Journal:  Infect Immun       Date:  2013-01-14       Impact factor: 3.441

6.  (1,3)-β-D-glucan as a prognostic marker of treatment response in invasive candidiasis.

Authors:  Siraya Jaijakul; Jose A Vazquez; Robert N Swanson; Luis Ostrosky-Zeichner
Journal:  Clin Infect Dis       Date:  2012-05-09       Impact factor: 9.079

7.  Development of a novel inhalational model of invasive pulmonary aspergillosis in rats and comparative evaluation of three biomarkers for its diagnosis.

Authors:  Suhail Ahmad; Ali A Al-Shaikh; Ziauddin Khan
Journal:  PLoS One       Date:  2014-06-23       Impact factor: 3.240

8.  β-D-Glucan Assay in Diagnosis and Monitoring the Systemic Candidiasis in a Rat Model.

Authors:  Hossein Khodadadi; Hossein Mirhendi; Koichi Makimura; Kazuo Satoh; Ladan Karimi; Shahrokh Izadi
Journal:  Jundishapur J Microbiol       Date:  2014-06-01       Impact factor: 0.747
  8 in total
  1 in total

1.  Biomarkers of fungal infection: Expert opinion on the current situation.

Authors:  E Bouza; B Almirante; J García Rodríguez; J Garnacho-Montero; M Salavert; P Muñoz; M Sanguinetti
Journal:  Rev Esp Quimioter       Date:  2019-11-14       Impact factor: 1.553
  1 in total

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