Literature DB >> 29967377

Diplotype analysis of NUDT15 variants and 6-mercaptopurine sensitivity in pediatric lymphoid neoplasms.

Shinichi Tsujimoto1,2, Tomoo Osumi1,3, Meri Uchiyama1, Ryota Shirai1, Takaya Moriyama4, Rina Nishii4, Yuji Yamada3, Ko Kudo5, Masahiro Sekiguchi6, Yuki Arakawa7, Masanori Yoshida1, Toru Uchiyama8, Kiminori Terui5, Shuichi Ito2, Katsuyoshi Koh7, Junko Takita6, Etsuro Ito5, Daisuke Tomizawa3, Atsushi Manabe9, Nobutaka Kiyokawa1, Jun J Yang4,10, Motohiro Kato11,12.   

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Year:  2018        PMID： 29967377      PMCID： PMC6289816          DOI： 10.1038/s41375-018-0190-1

Source DB:  PubMed          Journal:  Leukemia        ISSN： 0887-6924            Impact factor:   11.528


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  15 in total

1.  NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity.

Authors:  Takaya Moriyama; Rina Nishii; Virginia Perez-Andreu; Wenjian Yang; Federico Antillon Klussmann; Xujie Zhao; Ting-Nien Lin; Keito Hoshitsuki; Jacob Nersting; Kentaro Kihira; Ute Hofmann; Yoshihiro Komada; Motohiro Kato; Robert McCorkle; Lie Li; Katsuyoshi Koh; Cesar Rolando Najera; Shirley Kow-Yin Kham; Tomoya Isobe; Zhiwei Chen; Edwynn Kean-Hui Chiew; Deepa Bhojwani; Cynthia Jeffries; Yan Lu; Matthias Schwab; Hiroto Inaba; Ching-Hon Pui; Mary V Relling; Atsushi Manabe; Hiroki Hori; Kjeld Schmiegelow; Allen E J Yeoh; William E Evans; Jun J Yang
Journal:  Nat Genet       Date:  2016-02-15       Impact factor: 38.330

2.  The effects of inherited NUDT15 polymorphisms on thiopurine active metabolites in Japanese children with acute lymphoblastic leukemia.

Authors:  Takaya Moriyama; Rina Nishii; Ting-Nien Lin; Kentaro Kihira; Hidemi Toyoda; Nersting Jacob; Motohiro Kato; Katsuyoshi Koh; Hiroto Inaba; Atsushi Manabe; Kjeld Schmiegelow; Jun J Yang; Hiroki Hori
Journal:  Pharmacogenet Genomics       Date:  2017-06       Impact factor: 2.089

3.  Susceptibility to 6-MP toxicity conferred by a NUDT15 variant in Japanese children with acute lymphoblastic leukaemia.

Authors:  Yoichi Tanaka; Motohiro Kato; Daisuke Hasegawa; Kevin Y Urayama; Hisaya Nakadate; Kensuke Kondoh; Kozue Nakamura; Katsuyoshi Koh; Takako Komiyama; Atsushi Manabe
Journal:  Br J Haematol       Date:  2015-06-02       Impact factor: 6.998

Review 4.  Treatment and biology of pediatric acute lymphoblastic leukemia.

Authors:  Motohiro Kato; Atsushi Manabe
Journal:  Pediatr Int       Date:  2018-01       Impact factor: 1.524

5.  Most T790M mutations are present on the same EGFR allele as activating mutations in patients with non-small cell lung cancer.

Authors:  Noriko Hidaka; Eiji Iwama; Naoki Kubo; Taishi Harada; Kohta Miyawaki; Kentaro Tanaka; Isamu Okamoto; Eishi Baba; Koichi Akashi; Hiroyuki Sasaki; Yoichi Nakanishi
Journal:  Lung Cancer       Date:  2017-03-01       Impact factor: 5.705

6.  Combined Detection of NUDT15 Variants Could Highly Predict Thiopurine-induced Leukopenia in Chinese Patients with Inflammatory Bowel Disease: A Multicenter Analysis.

Authors:  Kang Chao; Xueding Wang; Qian Cao; Jiaming Qian; Kaichun Wu; Xia Zhu; Hong Yang; Jie Liang; Lang Lin; Zicheng Huang; Yu Zhang; Yibiao Huang; Yinghao Sun; Xianmin Xue; Min Huang; Pinjin Hu; Ping Lan; Xiang Gao
Journal:  Inflamm Bowel Dis       Date:  2017-09       Impact factor: 5.325

7.  NUDT15 and TPMT genetic polymorphisms are related to 6-mercaptopurine intolerance in children treated for acute lymphoblastic leukemia at the Children's Cancer Center of Lebanon.

Authors:  Nathalie K Zgheib; Reem Akika; Rami Mahfouz; Carol Al Aridi; Khaled M Ghanem; Raya Saab; Miguel R Abboud; Nidale Tarek; Hassan El Solh; Samar A Muwakkit
Journal:  Pediatr Blood Cancer       Date:  2016-08-31       Impact factor: 3.167

8.  A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia.

Authors:  Suk-Kyun Yang; Myunghee Hong; Jiwon Baek; Hyunchul Choi; Wanting Zhao; Yusun Jung; Talin Haritunians; Byong Duk Ye; Kyung-Jo Kim; Sang Hyoung Park; Soo-Kyung Park; Dong-Hoon Yang; Marla Dubinsky; Inchul Lee; Dermot P B McGovern; Jianjun Liu; Kyuyoung Song
Journal:  Nat Genet       Date:  2014-08-10       Impact factor: 38.330

9.  NUDT15 gene polymorphism related to mercaptopurine intolerance in Taiwan Chinese children with acute lymphoblastic leukemia.

Authors:  D-C Liang; C-P Yang; H-C Liu; T-H Jaing; S-H Chen; I-J Hung; T-C Yeh; T-H Lin; C-L Lai; C-Y Lai; L-Y Shih
Journal:  Pharmacogenomics J       Date:  2015-10-27       Impact factor: 3.550

10.  A rapid molecular approach for chromosomal phasing.

Authors:  John F Regan; Nolan Kamitaki; Tina Legler; Samantha Cooper; Niels Klitgord; George Karlin-Neumann; Catherine Wong; Shawn Hodges; Ryan Koehler; Svilen Tzonev; Steven A McCarroll
Journal:  PLoS One       Date:  2015-03-04       Impact factor: 3.240
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  10 in total

1.  High-resolution melt analysis enables simple genotyping of complicated polymorphisms of codon 18 rendering the NUDT15 diplotype.

Authors:  Yoichi Kakuta; Yasuhiro Izumiyama; Daisuke Okamoto; Takeru Nakano; Ryo Ichikawa; Takeo Naito; Rintaro Moroi; Masatake Kuroha; Yoshitake Kanazawa; Tomoya Kimura; Hisashi Shiga; Hisaaki Kudo; Naoko Minegishi; Yosuke Kawai; Katsushi Tokunaga; Masao Nagasaki; Yoshitaka Kinouchi; Yasuo Suzuki; Atsushi Masasmune
Journal:  J Gastroenterol       Date:  2019-10-22       Impact factor: 7.527

2.  Low NUDT15 expression levels due to biallelic NUDT15 variants and 6-mercaptopurine intolerance.

Authors:  Masanori Yoshida; Scott A Brown; Takaya Moriyama; Rina Nishii; Shin-Ichi Tsujimoto; Yuji Yamada; Kaoru Yoshida; Ryota Shirai; Tomoo Osumi; Tomoyuki Utano; Reiji Fukano; Ko Kudo; Kimiyoshi Sakaguchi; Yuki Arakawa; Katsuyoshi Koh; Masahiro Sekiguchi; Masahiro Sekimizu; Takako Miyamura; Hisashi Ishida; Takeshi Inukai; Daisuke Tomizawa; Nobutaka Kiyokawa; Motohiro Kato; Jun J Yang
Journal:  Br J Haematol       Date:  2022-07-29       Impact factor: 8.615

3.  Genetic Polymorphisms of Drug-Metabolizing Enzymes Involved in 6-Mercaptopurine-Induced Myelosuppression in Thai Pediatric Acute Lymphoblastic Leukemia Patients.

Authors:  Kanyarat Khaeso; Nontaya Nakkam; Patcharee Komwilaisak; Piyathida Wongmast; Su-On Chainansamit; Areerat Dornsena; Sirimas Kanjanawart; Suda Vannaprasaht; Wichittra Tassaneeyakul
Journal:  J Pediatr Genet       Date:  2020-09-08

4.  An international retrospective study for tolerability of 6-mercaptopurine on NUDT15 bi-allelic variants in children with acute lymphoblastic leukemia.

Authors:  Yoichi Tanaka; Allen Eng Juh Yeoh; Takaya Moriyama; Chi-Kong Li; Ko Kudo; Yuki Arakawa; Jassada Buaboonnam; Hui Zhang; Hsi-Che Liu; Hany Ariffin; Zhiwei Chen; Shirley K Y Kham; Rina Nishii; Daisuke Hasegawa; Junya Fujimura; Dai Keino; Kensuke Kondoh; Atsushi Sato; Takahiro Ueda; Masaki Yamamoto; Yuichi Taneyama; Moeko Hino; Masatoshi Takagi; Akira Ohara; Etsuro Ito; Katsuyoshi Koh; Hiroki Hori; Atsushi Manabe; Jun J Yang; Motohiro Kato
Journal:  Haematologica       Date:  2021-07-01       Impact factor: 9.941

5.  NUDT15 Genetic Variants in Chinese Han, Uighur, Kirghiz, and Dai Nationalities.

Authors:  Fang Zhang; Gulbanur Amat; Yanjing Tang; Ru Chen; Xin Tian; Wenting Hu; Changcheng Chen; Shuhong Shen; Yangyang Xie
Journal:  Front Pediatr       Date:  2022-04-14       Impact factor: 3.569

6.  A direct sequencing assay for pharmacogenetic testing of thiopurine-intolerant NUDT15 alleles in an Asian population.

Authors:  Kok-Siong Poon; Izz Irfan B Imran; Silvester Kheng-Han Chew; Patrice Tan; Karen Mei-Ling Tan
Journal:  BMC Res Notes       Date:  2022-04-25

7.  Long-Distance Phasing of a Tentative "Enhancer" Single-Nucleotide Polymorphism With CYP2D6 Star Allele Definitions.

Authors:  Erin C Boone; Wendy Y Wang; Roger Gaedigk; Mariana Cherner; Anick Bérard; J Steven Leeder; Neil A Miller; Andrea Gaedigk
Journal:  Front Pharmacol       Date:  2020-05-08       Impact factor: 5.810

8.  NUDT15 polymorphism and NT5C2 and PRPS1 mutations influence thiopurine sensitivity in acute lymphoblastic leukaemia cells.

Authors:  Shinpei Somazu; Yoichi Tanaka; Minori Tamai; Atsushi Watanabe; Keiko Kagami; Masako Abe; Daisuke Harama; Tamao Shinohara; Koshi Akahane; Kumiko Goi; Kanji Sugita; Takaya Moriyama; Jun Yang; Hiroaki Goto; Masayoshi Minegishi; Shotaro Iwamoto; Junko Takita; Takeshi Inukai
Journal:  J Cell Mol Med       Date:  2021-10-12       Impact factor: 5.310

9.  NUDT15 variants confer high incidence of second malignancies in children with acute lymphoblastic leukemia.

Authors:  Masanori Yoshida; Kazuhiko Nakabayashi; Wentao Yang; Aiko Sato-Otsubo; Shin-Ichi Tsujimoto; Hiroko Ogata-Kawata; Tomoko Kawai; Keisuke Ishiwata; Mika Sakamoto; Kohji Okamura; Kaoru Yoshida; Ryota Shirai; Tomoo Osumi; Takaya Moriyama; Rina Nishii; Hiroyuki Takahashi; Chikako Kiyotani; Yoko Shioda; Keita Terashima; Sae Ishimaru; Yuki Yuza; Masatoshi Takagi; Yuki Arakawa; Akitoshi Kinoshita; Moeko Hino; Toshihiko Imamura; Daisuke Hasegawa; Yozo Nakazawa; Mayuko Okuya; Harumi Kakuda; Nao Takasugi; Akiko Inoue; Kentaro Ohki; Takako Yoshioka; Shuichi Ito; Daisuke Tomizawa; Katsuyoshi Koh; Kimikazu Matsumoto; Masashi Sanada; Nobutaka Kiyokawa; Akira Ohara; Seishi Ogawa; Atsushi Manabe; Akira Niwa; Kenichiro Hata; Jun J Yang; Motohiro Kato
Journal:  Blood Adv       Date:  2021-12-14

10.  Determination of NUDT15 variants by targeted sequencing can identify compound heterozygosity in pediatric acute lymphoblastic leukemia patients.

Authors:  Chih-Hsiang Yu; Ya-Hsuan Chang; Der-Shiun Wang; Shiann-Tarng Jou; Chien-Yu Lin; Kai-Hsin Lin; Meng-Yao Lu; Lovely Raghav; Hsiu-Hao Chang; Kang-Hsi Wu; Shu-Wei Chou; Yu-Ling Ni; Dong-Tsamn Lin; Shu-Wha Lin; Hsuan-Yu Chen; Yung-Li Yang
Journal:  Sci Rep       Date:  2020-09-01       Impact factor: 4.379
  10 in total

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