The effect of bromodeoxyuridine on the segregation of the chicken-specific HPRT gene from Chinese hamster-chick red blood cell somatic hybrids.

The segregation of the chick-specific HPRT gene was studied in three Chinese hamster-chick red blood cell hybrid lines. The three lines showed individual segregation kinetics, the segregation taking place in an exponential-like fashion. Bromodeoxyuridine becomes incorporated into the nuclear DNA and increases the spontaneous segregation rate.