Literature DB >> 29964377

[EPIGENETIC MECHANISMS IN MODELS OF CHRONIC PAIN - A TARGET FOR NOVEL THERAPY?]

Saar Anis1,2, Amnon Mosek1,2,3.   

Abstract

INTRODUCTION: Evidence of epigenetics' role in pain response is accumulating in recent years. Tightly regulated epigenetic alterations on DNA and histones in the sensory circuit shape the physiological response to injury. Altering those epigenetic processes hinders therapeutic potential in pain. This review provides an overview of epigenomic modification in the development of chronic pain, and summarizes the therapeutic potential to alter epigenetic processes.

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Year:  2018        PMID： 29964377

Source DB:  PubMed          Journal:  Harefuah        ISSN： 0017-7768


  2 in total

1.  ZEB1 Induces Ddr1 Promoter Hypermethylation and Contributes to the Chronic Pain in Spinal Cord in Rats Following Oxaliplatin Treatment.

Authors:  Yi-Ying Chen; Kai-Sheng Jiang; Xiao-Hui Bai; Meng Liu; Su-Yan Lin; Ting Xu; Jia-You Wei; Dai Li; Yuan-Chang Xiong; Wen-Jun Xin; Zhen-Yu Li
Journal:  Neurochem Res       Date:  2021-05-25       Impact factor: 3.996

2.  Upregulation of TRPC6 Mediated by PAX6 Hypomethylation Is Involved in the Mechanical Allodynia Induced by Chemotherapeutics in Dorsal Root Ganglion.

Authors:  Xiang-Zhong Zhang; De-Xing Luo; Xiao-Hui Bai; Huan-Huan Ding; Meng Liu; Jie Deng; Jing-Wen Mai; Yan-Ling Yang; Su-Bo Zhang; Xiang-Cai Ruan; Xue-Qin Zhang; Wen-Jun Xin; Ting Xu
Journal:  Int J Neuropsychopharmacol       Date:  2020-04-23       Impact factor: 5.176
  2 in total

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