Literature DB >> 2996403

Immunopathogenesis of the acquired immunodeficiency syndrome.

D L Bowen, H C Lane, A S Fauci.   

Abstract

Many abnormalities of humoral and cellular immunity associated with the acquired immunodeficiency syndrome can be explained by the preferential infection of the T4 lymphocyte subset with the etiologic retrovirus. Severe alterations in specific T4 functions, such as inadequate immune responsiveness to specific antigen, result in devastating morbidity and mortality. On the basis of accumulated scientific knowledge, we outline the immunopathogenesis of this syndrome.

Entities:  

Keywords:  Acquired Immunodeficiency Syndrome; Antibodies; Biology; Diseases; Hematological Effects; Hemic System; Hiv Infections; Immunity; Immunoglobulin Alterations; Immunologic Factors; Physiology; Viral Diseases

Mesh：

Substances：

Year:  1985        PMID： 2996403     DOI： 10.7326/0003-4819-103-5-704

Source DB:  PubMed          Journal:  Ann Intern Med        ISSN： 0003-4819            Impact factor:   25.391


  59 in total

1.  Stability analysis of simple models for immune cells interacting with normal pathogens and immune system retroviruses.

Authors:  G Reibnegger; D Fuchs; A Hausen; E R Werner; G Werner-Felmayer; M P Dierich; H Wachter
Journal:  Proc Natl Acad Sci U S A       Date:  1989-03       Impact factor: 11.205

2.  Gastrointestinal candidiasis in a murine model of severe combined immunodeficiency syndrome.

Authors:  R Narayanan; W A Joyce; R A Greenfield
Journal:  Infect Immun       Date:  1991-06       Impact factor: 3.441

Review 3.  Genetic engineering of T cells for adoptive immunotherapy.

Authors:  Angel Varela-Rohena; Carmine Carpenito; Elena E Perez; Max Richardson; Richard V Parry; Michael Milone; John Scholler; Xueli Hao; Angela Mexas; Richard G Carroll; Carl H June; James L Riley
Journal:  Immunol Res       Date:  2008       Impact factor: 2.829

Review 4.  Potential therapeutics of vitamin E (tocopherol) in AIDS and HIV.

Authors:  Y Wang; R R Watson
Journal:  Drugs       Date:  1994-09       Impact factor: 9.546

5.  Entry of human immunodeficiency virus (HIV) into MT-2, human T cell leukemia virus carrier cell line.

Authors:  T Goto; S Harada; N Yamamoto; M Nakai
Journal:  Arch Virol       Date:  1988       Impact factor: 2.574

6.  Detection of three distinct patterns of T helper cell dysfunction in asymptomatic, human immunodeficiency virus-seropositive patients. Independence of CD4+ cell numbers and clinical staging.

Authors:  M Clerici; N I Stocks; R A Zajac; R N Boswell; D R Lucey; C S Via; G M Shearer
Journal:  J Clin Invest       Date:  1989-12       Impact factor: 14.808

7.  Role of antibodies to murine leukemia virus p15E transmembrane protein in immunotherapy against AKR leukemia: a model for studies in human acquired immunodeficiency syndrome.

Authors:  H J Thiel; H Schwarz; P Fischinger; D Bolognesi; W Schäfer
Journal:  Proc Natl Acad Sci U S A       Date:  1987-08       Impact factor: 11.205

8.  Infection of monocyte/macrophages by human T lymphotropic virus type III.

Authors:  D D Ho; T R Rota; M S Hirsch
Journal:  J Clin Invest       Date:  1986-05       Impact factor: 14.808

9.  Requirements for CD4+ cells and gamma interferon in resolution of established Cryptosporidium parvum infection in mice.

Authors:  W Chen; J A Harp; A G Harmsen
Journal:  Infect Immun       Date:  1993-09       Impact factor: 3.441

10.  Clinical utility of an enhanced human immunodeficiency virus type 1 p24 antigen capture assay.

Authors:  M B Vasudevachari; N P Salzman; D R Woll; C Mast; K W Uffelman; G Toedter; D Hoefheinz; J A Metcalf; H C Lane
Journal:  J Clin Immunol       Date:  1993-05       Impact factor: 8.317
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