| Literature DB >> 29963672 |
Shiying Li1, Xueyan Jiang, Rongrong Zheng, Shengjia Zuo, Linping Zhao, Guiling Fan, Jinghao Fan, Yonghua Liao, Xiyong Yu, Hong Cheng.
Abstract
An azobenzene-based heteromeric prodrug (hNDP) was prepared for targeted chemotherapy against hypoxic tumor. hNDP could divert the parent drug from nucleus to cytoplasm with lower toxicity, while the azoreduction of hNDP in hypoxia would activate the drug with a robust anti-tumor effect by initiating the apoptosis-related biochemical cascades.Entities:
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Year: 2018 PMID： 29963672 DOI： 10.1039/c8cc03430c
Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222