Saliva and Flavor Perception: Perspectives.

This paper reports the main trends and perspectives related to the current understanding of the relationships between saliva and flavor perception. Saliva is a key factor in flavor perception and controls the transport of flavor molecules to their receptors, their adsorption onto the mouth surfaces (i.e., oral mucosa), their metabolism by enzymatic modification, and the friction force in the oral cavity. The proteins in free saliva or in the mucosal pellicle contribute to flavor perception by interacting with or metabolizing flavor compounds. Most of these reactions were observed when using fresh whole saliva; however, they were absent or less frequently observed when using artificial saliva or depleted/frozen whole saliva. There is a need to better understand the role of protein aggregates in flavor perception. Within humans, there is great interindividual variation in salivary composition, which has been related to differences in flavor perception. However, the relative role of salivary proteins and the microbiota should be deeply investigated together with the impact of their composition on individual perception during life. Finally, future results must also consider cross-modal interactions at the brain level.