Kim Wervers1,2, Jolanda J Luime1,2, Ilja Tchetverikov1,2, Andreas H Gerards1,2, Marc R Kok1,2, Cathelijne W Y Appels1,2, Wiebo L van der Graaff1,2, Johannes H L M van Groenendael1,2, Lindy-Anne Korswagen1,2, Josien J Veris-van Dieren1,2, Johanna M W Hazes1,2, Marijn Vis3,4. 1. From the Dutch south-west Early Psoriatic Arthritis cohort (DEPAR): Department of Rheumatology, Erasmus University Medical Center, and Maasstad Hospital, and Sint Franciscus Gasthuis, Rotterdam; Albert Schweitzer Hospital, Dordrecht; Vlietland Hospital, Schiedam; Amphia Hospital, Breda; Rivas Hospital, Gorinchem; Reumazorg Zuid West Nederland, Roosendaal, the Netherlands. 2. K. Wervers, PhD Student, Department of Rheumatology, Erasmus University Medical Center; J.J. Luime, PhD, Department of Rheumatology, Erasmus University Medical Center; I. Tchetverikov, MD, PhD, Department of Rheumatology, Albert Schweitzer Hospital; M.R. Kok, MD, PhD, Department of Rheumatology, Maasstad Hospital; A.H. Gerards, MD, Department of Rheumatology, Vlietland Hospital; C.W. Appels, MD, Department of Rheumatology, Amphia Hospital; W.L. van der Graaff, MD, PhD, Department of Rheumatology, Rivas Hospital; J.H. van Groenendael, MD, Reumazorg Zuid West Nederland; L.A. Korswagen, MD, Department of Rheumatology, Sint Franciscus Gasthuis; J.J. Veris-van Dieren, MD, Reumazorg Zuid West Nederland; J.M. Hazes, MD, PhD, Department of Rheumatology, Erasmus University Medical Center; M. Vis, MD, PhD, Department of Rheumatology, Erasmus University Medical Center. 3. From the Dutch south-west Early Psoriatic Arthritis cohort (DEPAR): Department of Rheumatology, Erasmus University Medical Center, and Maasstad Hospital, and Sint Franciscus Gasthuis, Rotterdam; Albert Schweitzer Hospital, Dordrecht; Vlietland Hospital, Schiedam; Amphia Hospital, Breda; Rivas Hospital, Gorinchem; Reumazorg Zuid West Nederland, Roosendaal, the Netherlands. marijn.vis@erasmusmc.nl. 4. K. Wervers, PhD Student, Department of Rheumatology, Erasmus University Medical Center; J.J. Luime, PhD, Department of Rheumatology, Erasmus University Medical Center; I. Tchetverikov, MD, PhD, Department of Rheumatology, Albert Schweitzer Hospital; M.R. Kok, MD, PhD, Department of Rheumatology, Maasstad Hospital; A.H. Gerards, MD, Department of Rheumatology, Vlietland Hospital; C.W. Appels, MD, Department of Rheumatology, Amphia Hospital; W.L. van der Graaff, MD, PhD, Department of Rheumatology, Rivas Hospital; J.H. van Groenendael, MD, Reumazorg Zuid West Nederland; L.A. Korswagen, MD, Department of Rheumatology, Sint Franciscus Gasthuis; J.J. Veris-van Dieren, MD, Reumazorg Zuid West Nederland; J.M. Hazes, MD, PhD, Department of Rheumatology, Erasmus University Medical Center; M. Vis, MD, PhD, Department of Rheumatology, Erasmus University Medical Center. marijn.vis@erasmusmc.nl.
Abstract
OBJECTIVE: Psoriatic arthritis (PsA) is a multifaceted disease. Affecting joints, skin, entheses, and dactylitis, its effect on health-related quality of life (HRQOL) could be substantial. We aim to assess HRQOL in patients newly diagnosed with PsA and analyze its associations with disease manifestations. METHODS: Data collected at time of diagnosis from patients with PsA included in the Dutch south-west Early Psoriatic Arthritis cohort (DEPAR) study were used. HRQOL was assessed using 8 domains of the Medical Outcomes Study Short Form-36 (SF-36) questionnaire. Patients were classified based on primary manifestation in arthritis subtypes (i.e., mono-, oligo-, or polyarthritis) and other subtypes (i.e., enthesitis, dactylitis, and axial disease). In all patients, presence of arthritis, enthesitis, dactylitis, psoriasis, and chronic inflammatory back pain was determined. Multivariable linear regression was used to determine associations of PsA manifestations with HRQOL. RESULTS: Of 405 patients, primary manifestation was peripheral arthritis in 320 (78 monoarthritis, 151 oligoarthritis, and 91 polyarthritis), enthesitis in 37, axial disease in 9, and dactylitis in 39. Mean scores of SF-36 domains were lower than the Dutch reference population and similar across arthritis subtypes. A higher number of enthesitis locations and tender joints, and presence of chronic back pain, were independently associated with worse SF-36 scores. Psoriasis and dactylitis were not associated with worse scores. CONCLUSION: HRQOL was diminished in PsA at time of diagnosis compared to the Dutch reference population, and tender joints, enthesitis at clinical examination, and back pain as indicators of pain affected HRQOL.
OBJECTIVE:Psoriatic arthritis (PsA) is a multifaceted disease. Affecting joints, skin, entheses, and dactylitis, its effect on health-related quality of life (HRQOL) could be substantial. We aim to assess HRQOL in patients newly diagnosed with PsA and analyze its associations with disease manifestations. METHODS: Data collected at time of diagnosis from patients with PsA included in the Dutch south-west Early Psoriatic Arthritis cohort (DEPAR) study were used. HRQOL was assessed using 8 domains of the Medical Outcomes Study Short Form-36 (SF-36) questionnaire. Patients were classified based on primary manifestation in arthritis subtypes (i.e., mono-, oligo-, or polyarthritis) and other subtypes (i.e., enthesitis, dactylitis, and axial disease). In all patients, presence of arthritis, enthesitis, dactylitis, psoriasis, and chronic inflammatory back pain was determined. Multivariable linear regression was used to determine associations of PsA manifestations with HRQOL. RESULTS: Of 405 patients, primary manifestation was peripheral arthritis in 320 (78 monoarthritis, 151 oligoarthritis, and 91 polyarthritis), enthesitis in 37, axial disease in 9, and dactylitis in 39. Mean scores of SF-36 domains were lower than the Dutch reference population and similar across arthritis subtypes. A higher number of enthesitis locations and tender joints, and presence of chronic back pain, were independently associated with worse SF-36 scores. Psoriasis and dactylitis were not associated with worse scores. CONCLUSION: HRQOL was diminished in PsA at time of diagnosis compared to the Dutch reference population, and tender joints, enthesitis at clinical examination, and back pain as indicators of pain affected HRQOL.
Entities:
Keywords:
ENTHESITIS; HEALTH-RELATED QUALITY OF LIFE; MEDICAL OUTCOMES STUDY SHORT FORM-36; PSORIATIC ARTHRITIS
Authors: Laura C Coates; Johan K Wallman; Dennis McGonagle; Georg A Schett; Iain B McInnes; Philip J Mease; Lawrence Rasouliyan; Erhard Quebe-Fehling; Darren L Asquith; Andreas E R Fasth; Luminita Pricop; Corine Gaillez Journal: Arthritis Res Ther Date: 2019-12-04 Impact factor: 5.156
Authors: Philip J Mease; Soumya D Chakravarty; Robert R McLean; Taylor Blachley; Toana Kawashima; Iris Lin; Arthur Kavanaugh; Alexis Ogdie Journal: ACR Open Rheumatol Date: 2022-02-26
Authors: Fazira R Kasiem; Marc R Kok; Jolanda J Luime; Ilja Tchetverikov; Kim Wervers; Lindy-Anne Korswagen; Nastasja H A M Denissen; Yvonne P M Goekoop-Ruiterman; Maikel van Oosterhout; Faouzia Fodili; Johanna M W Hazes; Marijn Vis Journal: Rheumatology (Oxford) Date: 2022-04-11 Impact factor: 7.580