| Literature DB >> 29960019 |
Shan-Jen Lin1, Yu-Tang Chin2, Yih Ho3, Szu-Yi Chou4, Yu-Chen Sh Yang5, André Wendindondé Nana6, Kuan-Wei Su1, Yee-Tong Lim7, Kuan Wang8, Sheng-Yang Lee9, Ya-Jung Shih2, Yi-Ru Chen2, Jacqueline Whang-Peng10, Paul J Davis11, Hung-Yun Lin12, Earl Fu13.
Abstract
Programmed death-ligand 1 (PD-L1) is a critical regulator to defend tumor cells against immune surveillance. Thyroid hormone has been shown to induce PD-L1 expression in cancer cells. Its nano-particulated analogue, nano-diamino-tetrac (NDAT; Nanotetrac) is an anticancer/anti-angiogenic agent. In the current study, the inhibitory mechanism by which NDAT inhibited PD-L1 mRNA abundance and PD-L1 protein content in oral cancer cells was investigated. NDAT inhibited inducible PD-L1 expression and protein accumulation by the inhibition of activated ERK1/2 and PI3K. Knockdown PD-L1 also inhibited the proliferation of oral cancer cells which suggests that the inhibitory effect of NDAT on PD-L1 expression maybe is one of the critical mechanisms for NDAT-induced anti-proliferative effect in oral cancer cells.Entities:
Keywords: NDAT; Oral cancer; PD-L1; Proliferation; Thyroxine
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Year: 2018 PMID： 29960019 DOI： 10.1016/j.fct.2018.06.058
Source DB: PubMed Journal: Food Chem Toxicol ISSN： 0278-6915 Impact factor: 6.023