| Literature DB >> 29959320 |
Nicola Pirastu1, Peter K Joshi2, Paul S de Vries3, Marilyn C Cornelis4, Paul M McKeigue5, NaNa Keum6,7, Nora Franceschini8, Marco Colombo5, Edward L Giovannucci7,9,10, Athina Spiliopoulou5,11, Lude Franke12, Kari E North8, Peter Kraft13, Alanna C Morrison3, Tõnu Esko14,15, James F Wilson2,16.
Abstract
We have been alerted that in our recent Article the calculations used to transform the heritability from the observed scale to the liability scale did not take into account the individuals in category 2 of the baldness scale, who were removed in our original analysis. This led to an overestimation of the heritability on the liability scale, which should have been 0.62 instead of 0.94. Moreover, in the Title and in the Abstract, we report that we can explain 38% of the risk, while in fact that is the proportion of heritability explained by the loci we discovered. These errors do not substantially change the paper or its conclusions apart from the statement MBP is therefore probably one of the most heritable complex traits. Genome-wide significant associations and pathway analyses are not affected in any way and male-pattern baldness remains less genetically complex than other complex traits. We wish to thank Yap et al. for bringing this to our attention.Entities:
Year: 2018 PMID: 29959320 PMCID: PMC6026128 DOI: 10.1038/s41467-018-04857-7
Source DB: PubMed Journal: Nat Commun ISSN: 2041-1723 Impact factor: 14.919