Literature DB >> 29959320

Author Correction: GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk.

Nicola Pirastu1, Peter K Joshi2, Paul S de Vries3, Marilyn C Cornelis4, Paul M McKeigue5, NaNa Keum6,7, Nora Franceschini8, Marco Colombo5, Edward L Giovannucci7,9,10, Athina Spiliopoulou5,11, Lude Franke12, Kari E North8, Peter Kraft13, Alanna C Morrison3, Tõnu Esko14,15, James F Wilson2,16.   

Abstract

We have been alerted that in our recent Article the calculations used to transform the heritability from the observed scale to the liability scale did not take into account the individuals in category 2 of the baldness scale, who were removed in our original analysis. This led to an overestimation of the heritability on the liability scale, which should have been 0.62 instead of 0.94. Moreover, in the Title and in the Abstract, we report that we can explain 38% of the risk, while in fact that is the proportion of heritability explained by the loci we discovered. These errors do not substantially change the paper or its conclusions apart from the statement MBP is therefore probably one of the most heritable complex traits. Genome-wide significant associations and pathway analyses are not affected in any way and male-pattern baldness remains less genetically complex than other complex traits. We wish to thank Yap et al. for bringing this to our attention.

Entities:  

Year:  2018        PMID: 29959320      PMCID: PMC6026128          DOI: 10.1038/s41467-018-04857-7

Source DB:  PubMed          Journal:  Nat Commun        ISSN: 2041-1723            Impact factor:   14.919


Correction to: Nature Communications 10.1038/s41467-017-01490-8, published online 17 November 2017. We have been alerted[1] that in our recent Article[2] the calculations used to transform the heritability from the observed scale to the liability scale did not take into account the individuals in category 2 of the baldness scale, who were removed in our original analysis. This led to an overestimation of the heritability on the liability scale, which should have been 0.62 instead of 0.94. Moreover, in the Title and in the Abstract, we report that we can explain 38% of the risk, while in fact that is the proportion of heritability explained by the loci we discovered. These errors do not substantially change the paper or its conclusions apart from the statement MBP is therefore probably one of the most heritable complex traits. Genome-wide significant associations and pathway analyses are not affected in any way and male-pattern baldness remains less genetically complex than other complex traits. We wish to thank Yap et al. for bringing this to our attention.
  2 in total

1.  GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk.

Authors:  Nicola Pirastu; Peter K Joshi; Paul S de Vries; Marilyn C Cornelis; Paul M McKeigue; NaNa Keum; Nora Franceschini; Marco Colombo; Edward L Giovannucci; Athina Spiliopoulou; Lude Franke; Kari E North; Peter Kraft; Alanna C Morrison; Tõnu Esko; James F Wilson
Journal:  Nat Commun       Date:  2017-11-17       Impact factor: 14.919

2.  Misestimation of heritability and prediction accuracy of male-pattern baldness.

Authors:  Chloe X Yap; Julia Sidorenko; Riccardo E Marioni; Loic Yengo; Naomi R Wray; Peter M Visscher
Journal:  Nat Commun       Date:  2018-06-29       Impact factor: 14.919

  2 in total

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