Myriam Salameh1, Jennifer Lee2, Glenn Palomaki3, Elizabeth Eklund4, Patrizia Curran1, Jose Antonio Rojas Suarez5, Geralyn Lambert-Messerlian3, Ghada Bourjeily6. 1. The Miriam Hospital, Department of Medicine, United States. 2. Warren Alpert Medical School at Brown University, United States. 3. Warren Alpert Medical School at Brown University, United States; Department of Pathology and Laboratory Medicine, Women and Infants Hospital, United States. 4. Department of Pathology and Laboratory Medicine, Women and Infants Hospital, United States. 5. The University of Cartagena, Colombia. 6. The Miriam Hospital, Department of Medicine, United States; Warren Alpert Medical School at Brown University, United States. Electronic address: ghada_bourjeily@brown.edu.
Abstract
INTRODUCTION: Snoring, the symptom of partial airway obstruction during sleep, is a common complaint during pregnancy and is associated with adverse perinatal outcomes. Mechanisms underlying this association have not been studied. We investigated the relationship between snoring in pregnancy and maternal serum markers of feto-placental wellbeing. METHODS: We conducted a secondary analysis of a cross sectional study designed to investigate perinatal outcomes of sleep-disordered breathing. Women admitted for delivery were systematically selected and answered a questionnaire about snoring using the Multivariable Apnea Prediction Index. Participants who had screening markers measured were included and divided into snorers and non -snorers. Markers measured included first and second trimester Down syndrome screening markers, reported as multiples of the median (MoM). An additional analysis was performed with snorers categorized as acute or chronic snorers based on duration of snoring in relation to pregnancy. RESULTS: While significant differences were noted in co-morbid maternal medical conditions between snorers and non-snorers, there were no significant differences in the neonatal outcomes assessed between the two groups. No significant differences were noted in any of the first trimester (PAPP-A) or second trimester (AFP, uE3, hCG, inhibin-A) markers between snorers and non-snorers, p > 0.25. In addition, no significant differences in marker levels were noted between acute and chronic snorers. CONCLUSION: Snoring is not associated with alterations in the markers of fetal or placental wellbeing tested here and suggests that there are alternative mechanisms underlying the association between snoring and adverse perinatal outcomes.
INTRODUCTION: Snoring, the symptom of partial airway obstruction during sleep, is a common complaint during pregnancy and is associated with adverse perinatal outcomes. Mechanisms underlying this association have not been studied. We investigated the relationship between snoring in pregnancy and maternal serum markers of feto-placental wellbeing. METHODS: We conducted a secondary analysis of a cross sectional study designed to investigate perinatal outcomes of sleep-disordered breathing. Women admitted for delivery were systematically selected and answered a questionnaire about snoring using the Multivariable Apnea Prediction Index. Participants who had screening markers measured were included and divided into snorers and non -snorers. Markers measured included first and second trimester Down syndrome screening markers, reported as multiples of the median (MoM). An additional analysis was performed with snorers categorized as acute or chronic snorers based on duration of snoring in relation to pregnancy. RESULTS: While significant differences were noted in co-morbid maternal medical conditions between snorers and non-snorers, there were no significant differences in the neonatal outcomes assessed between the two groups. No significant differences were noted in any of the first trimester (PAPP-A) or second trimester (AFP, uE3, hCG, inhibin-A) markers between snorers and non-snorers, p > 0.25. In addition, no significant differences in marker levels were noted between acute and chronic snorers. CONCLUSION: Snoring is not associated with alterations in the markers of fetal or placental wellbeing tested here and suggests that there are alternative mechanisms underlying the association between snoring and adverse perinatal outcomes.
Authors: Sanja Jelic; Margherita Padeletti; Steven M Kawut; Christopher Higgins; Stephen M Canfield; Duygu Onat; Paolo C Colombo; Robert C Basner; Phillip Factor; Thierry H LeJemtel Journal: Circulation Date: 2008-04-14 Impact factor: 29.690
Authors: Louise M O'Brien; Alexandra S Bullough; Jocelynn T Owusu; Kimberley A Tremblay; Cynthia A Brincat; Mark C Chames; John D Kalbfleisch; Ronald D Chervin Journal: Sleep Date: 2013-11-01 Impact factor: 5.849
Authors: Jennifer Lee; Elizabeth E Eklund; Geralyn Lambert-Messerlian; Glenn E Palomaki; Kristen Butterfield; Patrizia Curran; Ghada Bourjeily Journal: J Womens Health (Larchmt) Date: 2017-01-19 Impact factor: 2.681