Sumit Randhir Singh1, Alessandro Invernizzi2, Mohammed Abdul Rasheed1, Carlo Cagini3, Abhilash Goud1, Kiran Kumar Vupparaboina1, Mariano Cozzi2, Marco Lupidi3, Jay Chhablani4. 1. Smt. Kanuri Santhamma Centre for Vitreo-Retinal Diseases, L V Prasad Eye Institute, Hyderabad, India. 2. Eye Clinic, Department of Biomedical and Clinical Science "Luigi Sacco", University of Milan, Milan, Italy. 3. Department of Biochemical and Surgical Sciences, Section of Ophthalmology, University of Perugia, Perugia, Italy. 4. Smt. Kanuri Santhamma Centre for Vitreo-Retinal Diseases, L V Prasad Eye Institute, Hyderabad, India. Electronic address: jay.chhablani@gmail.com.
Abstract
PURPOSE: To report variation of choroidal vascularity index (CVI) in macular and mid-equator areas in healthy subjects using wide-field optical coherence tomography (WF-OCT). DESIGN: Prospective, cross-sectional study. METHODS: Setting: Two-center study. STUDY POPULATION: Twenty eyes of 20 healthy subjects. OBSERVATION PROCEDURE: Single high-definition scans passing through the fovea in both vertical and horizontal meridians were studied. Images were taken in primary gaze and extremes of gaze and a manual montage was created. A previously reported semi-automated algorithm was used to calculate the CVI in macular, superior, inferior, temporal, and nasal quadrants. MAIN OUTCOME MEASURES: Difference in CVI in macular area and 4 quadrants. RESULTS: Twenty eyes from 20 subjects were enrolled in the study. The mean age was 28.85 ± 6.29 years with men comprising 9 of the 20 subjects (45.0%). The refractive error (spherical equivalent) ranged from -3.00 to +0.75 diopters. The average CVI in the macular area (40.01 ± 7.67) was significantly smaller than in any of the other fundus areas (all P < .01). The maximum CVI was seen in the nasal quadrant (50.84 ± 5.64), followed by inferior (47.93 ± 9.31), temporal (46.14 ± 7.06), and superior (45.72 ± 7.69). The nasal quadrant was found to have the least coefficient of variation (CV) of CVI (0.11) while the inferior and macular area had the highest CV (0.19). CONCLUSIONS: We report CVI in WF-OCT in healthy young individuals. CVI seems to have a wide topographic variation. The macular area had the least CVI. CVI values are more consistent with lesser CV in the nasal quadrant compared to the other quadrants and macular area.
PURPOSE: To report variation of choroidal vascularity index (CVI) in macular and mid-equator areas in healthy subjects using wide-field optical coherence tomography (WF-OCT). DESIGN: Prospective, cross-sectional study. METHODS: Setting: Two-center study. STUDY POPULATION: Twenty eyes of 20 healthy subjects. OBSERVATION PROCEDURE: Single high-definition scans passing through the fovea in both vertical and horizontal meridians were studied. Images were taken in primary gaze and extremes of gaze and a manual montage was created. A previously reported semi-automated algorithm was used to calculate the CVI in macular, superior, inferior, temporal, and nasal quadrants. MAIN OUTCOME MEASURES: Difference in CVI in macular area and 4 quadrants. RESULTS: Twenty eyes from 20 subjects were enrolled in the study. The mean age was 28.85 ± 6.29 years with men comprising 9 of the 20 subjects (45.0%). The refractive error (spherical equivalent) ranged from -3.00 to +0.75 diopters. The average CVI in the macular area (40.01 ± 7.67) was significantly smaller than in any of the other fundus areas (all P < .01). The maximum CVI was seen in the nasal quadrant (50.84 ± 5.64), followed by inferior (47.93 ± 9.31), temporal (46.14 ± 7.06), and superior (45.72 ± 7.69). The nasal quadrant was found to have the least coefficient of variation (CV) of CVI (0.11) while the inferior and macular area had the highest CV (0.19). CONCLUSIONS: We report CVI in WF-OCT in healthy young individuals. CVI seems to have a wide topographic variation. The macular area had the least CVI. CVI values are more consistent with lesser CV in the nasal quadrant compared to the other quadrants and macular area.
Authors: Hao Zhou; Yining Dai; Yingying Shi; Jonathan F Russell; Cancan Lyu; Jila Noorikolouri; William J Feuer; Zhongdi Chu; Qinqin Zhang; Luis de Sisternes; Mary K Durbin; Giovanni Gregori; Philip J Rosenfeld; Ruikang K Wang Journal: Ophthalmol Retina Date: 2019-10-01