| Literature DB >> 2995853 |
A Y Chweh, R A Ulloque, E A Swinyard, H H Wolf.
Abstract
The effect of picrotoxinin on [3H]flunitrazepam binding to benzodiazepine receptors was investigated. In mouse forebrain membranes, picrotoxinin inhibited basal, GABA- and pentobarbital-stimulated [3H]flunitrazepam binding; this inhibitory activity was temperature- and chloride ion-dependent. Scatchard analysis of the data indicates that picrotoxinin decreases the number of binding sites without altering binding affinity. In cerebellar membranes, picrotoxinin did not alter [3H]flunitrazepam receptor binding.Entities:
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Year: 1985 PMID： 2995853 DOI： 10.1007/bf00964624
Source DB: PubMed Journal: Neurochem Res ISSN： 0364-3190 Impact factor: 3.996