Literature DB >> 2995814

Insertion of DNA sequences into the human chromosomal beta-globin locus by homologous recombination.

O Smithies, R G Gregg, S S Boggs, M A Koralewski, R S Kucherlapati.   

Abstract

A 'rescuable' plasmid containing globin gene sequences allowing recombination with homologous chromosomal sequences has enabled us to produce, score and clone mammalian cells with the plasmid integrated into the human beta-globin locus. The planned modification was achieved in about one per thousand transformed cells whether or not the target gene was expressed.

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Year:  1985        PMID： 2995814     DOI： 10.1038/317230a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  275 in total

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Review 3.  Manipulating the mammalian genome by homologous recombination.

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Review 4.  Gene targeting in the mouse: advances in introduction of transgenes into the genome by homologous recombination.

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Review 8.  Bone marrow transplantation for thalassaemia major.

Authors:  D I Evans
Journal:  J Clin Pathol       Date:  1992-07       Impact factor: 3.411

9.  Homologous plasmid recombination is elevated in immortally transformed cells.

Authors:  G K Finn; B W Kurz; R Z Cheng; R J Shmookler Reis
Journal:  Mol Cell Biol       Date:  1989-09       Impact factor: 4.272

10.  Gene targeting in yeast is initiated by two independent strand invasions.

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Journal:  Proc Natl Acad Sci U S A       Date:  2004-10-15       Impact factor: 11.205
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