Literature DB >> 29957028

Cellular target engagement: a new paradigm in drug discovery.

Ivan Babic1, Santosh Kesari1, Elmar Nurmemmedov1.   

Abstract

Keywords:  cellular; discovery; drug; engagement; target

Mesh：

Substances：

Year:  2018        PMID： 29957028     DOI： 10.4155/fmc-2018-0139

Source DB:  PubMed          Journal:  Future Med Chem        ISSN： 1756-8919            Impact factor:   3.808


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  6 in total

1.  Design and characterization of a time-domain optical tomography platform for mesoscopic lifetime imaging.

Authors:  Shan Gao; Mengzhou Li; Jason T Smith; Xavier Intes
Journal:  Biomed Opt Express       Date:  2022-08-10       Impact factor: 3.562

Review 2.  Why 90% of clinical drug development fails and how to improve it?

Authors:  Duxin Sun; Wei Gao; Hongxiang Hu; Simon Zhou
Journal:  Acta Pharm Sin B       Date:  2022-02-11       Impact factor: 14.903

3.  Structure‒tissue exposure/selectivity relationship (STR) correlates with clinical efficacy/safety.

Authors:  Wei Gao; Hongxiang Hu; Lipeng Dai; Miao He; Hebao Yuan; Huixia Zhang; Jinhui Liao; Bo Wen; Yan Li; Maria Palmisano; Mohamed Dit Mady Traore; Simon Zhou; Duxin Sun
Journal:  Acta Pharm Sin B       Date:  2022-02-23       Impact factor: 14.903

4.  Evolution of a 4-Benzyloxy-benzylamino Chemotype to Provide Efficacious, Potent, and Isoform Selective PPARα Agonists as Leads for Retinal Disorders.

Authors:  Xiaozheng Dou; Dinesh Nath; Henry Shin; Elmar Nurmemmedov; Philip C Bourne; Jian-Xing Ma; Adam S Duerfeldt
Journal:  J Med Chem       Date:  2020-03-10       Impact factor: 8.039

5.  Peptidomimetic Polo-Box-Targeted Inhibitors that Engage PLK1 in Tumor Cells and Are Selective against the PLK3 Tumor Suppressor.

Authors:  Merissa Baxter; Danda Chapagai; Sandra Craig; Cecilia Hurtado; Jessy Varghese; Elmar Nurmemmedov; Michael D Wyatt; Campbell McInnes
Journal:  ChemMedChem       Date:  2020-04-28       Impact factor: 3.540

6.  Targeting breast cancer metabolism with a novel inhibitor of mitochondrial ATP synthesis.

Authors:  Myoung Sook Kim; Ramkishore Gernapudi; Yessenia Cedeño Cedeño; Brian M Polster; Ramon Martinez; Paul Shapiro; Santosh Kesari; Elmar Nurmemmedov; Antonino Passaniti
Journal:  Oncotarget       Date:  2020-10-27
  6 in total

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