Yuk Jing Loke1, Evelyne Muggli2,3, Linh Nguyen1, Joanne Ryan3,4,5, Richard Saffery3,5, Elizabeth J Elliott6,7, Jane Halliday2,3, Jeffrey M Craig1,3,8. 1. Environmental & Genetic Epidemiology Research, Murdoch Children's Research Institute, the Royal Children's Hospital, Flemington Road, Parkville, Victoria 3052, Australia. 2. Public Health Genetics, Murdoch Children's Research Institute, the Royal Children's Hospital, Flemington Road, Parkville, Victoria 3052, Australia. 3. Department of Paediatrics, University of Melbourne, Parkville, Victoria 3052, Australia. 4. Department of Epidemiology & Preventive Medicine, Monash University, Melbourne, Victoria 3004, Australia. 5. Cancer & Disease Epigenetics, Murdoch Children's Research Institute, the Royal Children's Hospital, Flemington Road, Parkville, Victoria 3052, Australia. 6. Discipline of Child & Adolescent Health, School of Medicine and Health, University of Sydney, Sydney 2006, New South Wales, Australia. 7. Australian Paediatric Surveillance Unit, Sydney Childrens Hospitals Network, Westmead, Sydney, New South Wales, Australia. 8. Centre for Molecular and Medical Research, Deakin University, Geelong Waurn Ponds Campus, Locked Bag 20000, Geelong, Victoria 3220, Australia.
Abstract
AIM: Epigenetic changes, in particular in the placenta, may mediate the effects of prenatal alcohol exposure (PAE) on children's health. We examined the relationship between PAE patterns, based on dose and timing, and placental global DNA methylation. METHODS: Using linear regression analysis, we examined the association between different PAE categories and placental global DNA methylation (n = 187), using the proxy measure of Alu-interspersed repeats. RESULTS: Following adjustment for important covariates, we found no evidence of an association between PAE and placental global DNA methylation overall. However, when stratifying by newborn sex, PAE throughout pregnancy was associated with higher placental global DNA methylation (1.5%; p = 0.01) of male newborns. CONCLUSION: PAE may have sex-specific effects on placental global DNA methylation if alcohol is consumed throughout pregnancy.
AIM: Epigenetic changes, in particular in the placenta, may mediate the effects of prenatal alcohol exposure (PAE) on children's health. We examined the relationship between PAE patterns, based on dose and timing, and placental global DNA methylation. METHODS: Using linear regression analysis, we examined the association between different PAE categories and placental global DNA methylation (n = 187), using the proxy measure of Alu-interspersed repeats. RESULTS: Following adjustment for important covariates, we found no evidence of an association between PAE and placental global DNA methylation overall. However, when stratifying by newborn sex, PAE throughout pregnancy was associated with higher placental global DNA methylation (1.5%; p = 0.01) of male newborns. CONCLUSION:PAE may have sex-specific effects on placental global DNA methylation if alcohol is consumed throughout pregnancy.
Entities:
Keywords:
global DNA methylation; placenta; prenatal alcohol exposure
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