Literature DB >> 29956163

The Use of Biodegradable Nanoparticles for Tolerogenic Therapy of Allergic Inflammation.

Charles B Smarr1,2, Stephen D Miller3.   

Abstract

Antigen-specific tolerance is the ultimate aim of treatment of allergic diseases. Here, we describe methods for the use of biodegradable nanoparticles to safely induce tolerance for the prevention and treatment of allergic inflammation in mice. Antigen is either conjugated to the surface of carboxylated poly(lactide-co-glycolide) (PLG) or encapsulated within PLG nanoparticles, and the resulting antigen-associated nanoparticles are then washed prior to intravenous injection to inhibit antigen-specific allergic immune responses.

Entities:  

Keywords:  Allergy; Immunotherapy; Nanoparticles; Th2; Tolerance

Mesh：

Substances：

Year:  2018        PMID： 29956163      PMCID： PMC6830576          DOI： 10.1007/978-1-4939-7896-0_25

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  10 in total

1.  Pathogenesis of NOD diabetes is initiated by reactivity to the insulin B chain 9-23 epitope and involves functional epitope spreading.

Authors:  Suchitra Prasad; Adam P Kohm; Jeffrey S McMahon; Xunrong Luo; Stephen D Miller
Journal:  J Autoimmun       Date:  2012-05-28       Impact factor: 7.094

2.  Tolerance induced by apoptotic antigen-coupled leukocytes is induced by PD-L1+ and IL-10-producing splenic macrophages and maintained by T regulatory cells.

Authors:  Daniel R Getts; Danielle M Turley; Cassandra E Smith; Christopher T Harp; Derrick McCarthy; Emma M Feeney; Meghann Teague Getts; Aaron J Martin; Xunrong Luo; Rachael L Terry; Nicholas J C King; Stephen D Miller
Journal:  J Immunol       Date:  2011-08-05       Impact factor: 5.422

3.  Antigen-fixed leukocytes tolerize Th2 responses in mouse models of allergy.

Authors:  Charles B Smarr; Chia-Lin Hsu; Adam J Byrne; Stephen D Miller; Paul J Bryce
Journal:  J Immunol       Date:  2011-10-05       Impact factor: 5.422

4.  An antigen-encapsulating nanoparticle platform for TH1/17 immune tolerance therapy.

Authors:  Derrick P McCarthy; Jonathan Woon-Teck Yap; Christopher T Harp; W Kelsey Song; Jeane Chen; Ryan M Pearson; Stephen D Miller; Lonnie D Shea
Journal:  Nanomedicine       Date:  2016-10-06       Impact factor: 5.307

Review 5.  Antigen-specific tolerance in immunotherapy of Th2-associated allergic diseases.

Authors:  Charles B Smarr; Paul J Bryce; Stephen D Miller
Journal:  Crit Rev Immunol       Date:  2013       Impact factor: 2.214

6.  Microparticles bearing encephalitogenic peptides induce T-cell tolerance and ameliorate experimental autoimmune encephalomyelitis.

Authors:  Daniel R Getts; Aaron J Martin; Derrick P McCarthy; Rachael L Terry; Zoe N Hunter; Woon Teck Yap; Meghann Teague Getts; Michael Pleiss; Xunrong Luo; Nicholas J C King; Lonnie D Shea; Stephen D Miller
Journal:  Nat Biotechnol       Date:  2012-11-18       Impact factor: 54.908

7.  Biodegradable antigen-associated PLG nanoparticles tolerize Th2-mediated allergic airway inflammation pre- and postsensitization.

Authors:  Charles B Smarr; Woon Teck Yap; Tobias P Neef; Ryan M Pearson; Zoe N Hunter; Igal Ifergan; Daniel R Getts; Paul J Bryce; Lonnie D Shea; Stephen D Miller
Journal:  Proc Natl Acad Sci U S A       Date:  2016-04-18       Impact factor: 11.205

8.  Quantification of particle-conjugated or particle-encapsulated peptides on interfering reagent backgrounds.

Authors:  Woon Teck Yap; W Kelsey Song; Niharika Chauhan; P Nina Scalise; Radhika Agarwal; Stephen D Miller; Lonnie D Shea
Journal:  Biotechniques       Date:  2014-07-01       Impact factor: 1.993

9.  Expanding antigen-specific regulatory networks to treat autoimmunity.

Authors:  Xavier Clemente-Casares; Jesus Blanco; Poornima Ambalavanan; Jun Yamanouchi; Santiswarup Singha; Cesar Fandos; Sue Tsai; Jinguo Wang; Nahir Garabatos; Cristina Izquierdo; Smriti Agrawal; Michael B Keough; V Wee Yong; Eddie James; Anna Moore; Yang Yang; Thomas Stratmann; Pau Serra; Pere Santamaria
Journal:  Nature       Date:  2016-02-17       Impact factor: 49.962

10.  A biodegradable nanoparticle platform for the induction of antigen-specific immune tolerance for treatment of autoimmune disease.

Authors:  Zoe Hunter; Derrick P McCarthy; Woon Teck Yap; Christopher T Harp; Daniel R Getts; Lonnie D Shea; Stephen D Miller
Journal:  ACS Nano       Date:  2014-02-27       Impact factor: 15.881
  10 in total

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