| Literature DB >> 29953560 |
Mercè Borràs Sans, Miguel Pérez-Fontán, Montserrat Martinez-Alonso, Auxiliadora Bajo, Àngels Betriu, José M Valdivielso, Elvira Fernández.
Abstract
[This corrects the article DOI: 10.1371/journal.pone.0186921.].Entities:
Year: 2018 PMID: 29953560 PMCID: PMC6023218 DOI: 10.1371/journal.pone.0200226
Source DB: PubMed Journal: PLoS One ISSN: 1932-6203 Impact factor: 3.240
Main Baseline characteristics according to dialysis modality.
| PD | HD | p | |
|---|---|---|---|
| (n = 237) | (n = 237) | ||
| Males (%) | 137 (58) | 146 (61.8) | 0.45 |
| Age (years) | 52 [42;63] | 55 [43;63] | 0.11 |
| Smoker (former/current) (%) | 135 (57) | 137 (58) | 0.92 |
| Diabetes (%) | 43 (18.1) | 43 (18.1) | 1 |
| Hypertension (%) | 219 (92.4) | 199 (84) | 0.007 |
| Dyslipidemia (%) | 153 (64.6) | 123 (47.7) | <0.001 |
| Etiology of renal disease (%): | 0.670 | ||
| Diabetic nephropathy | 25 (10.5) | 27 (11.4) | |
| Vascular disease | 23 (9.7) | 29 (12.2) | |
| Others | 189 (79.7) | 181 (76.4) | |
| Dialysis time (months) | 13.7 [6.2;28.9] | 14.3 [6.41;28.6] | 0.91 |
| Body mass index (kg/m2) | 26.4 [23.3;29.2] | 25.3 [23;28.6] | 0.23 |
| Systolic Blood Pressure (mmHg) | 140 [129;159] | 135 [120;151] | 0.001 |
| Diastolic Blood Pressure (mm Hg) | 83 [77;94] | 80 [70;88] | <0.001 |
| Pulse Pressure (mmHg) | 56 [45;69] | 55 [46;63] | 0.53 |
| Serum glucose (mmol/L) | 5.05 [2.96;6.10] | 5.05 [4.56;6.10] | 0.838 |
| Urea (mmol/L) | 21.5 [17.6;25.8] | 20.8 [15.8;25] | 0.07 |
| Creatinine (μmol/L) | 682.5 [519.8;884] | 727.5 [574.6;884] | 0.1 |
| Total colesterol (mmol/L) | 4.58 [3.99;5.20] | 3.91 [3.37;4.53] | <0.001 |
| HDL-cholesterol (mmol/L) | 1.22 [1.01;1.48] | 1.09 [0.90;1.29] | <0.001 |
| LDL-cholesterol (mmol/L) | 2.66 [2.07;5.15] | 2.07 [1.63;2.64] | <0.001 |
| Triglycerides (mmol/L) | 1.34 [1.07;1.87] | 1.41 [1.03;1.92] | 0.75 |
| Serum uric acid (μmol/L) | 345.1 [303.4;401.6] | 362.9 [321.3;425.4] | 0.006 |
| hs C-Reactive Protein (nmol/L) | 19 [8.95;49.9] | 22.47 [10.09;58.66] | 0.23 |
| Albumin (mol/L) | 0.59 [0.54;0.62] | 0.59 [0.54;0.64] | 0.025 |
| Hemoglobin (mmol/L) | 7.2 [7.01;8.01] | 7.26 [6.70;7.76] | <0.001 |
| Corrected calcium (mmol/L) | 2.3 [2.20;2.42] | 2.26 [2.16;2.36] | <0.001 |
| Phosphate (mmol/L) | 1.6 [1.35;1.84] | 1.54 [1.25;1.79] | 0.035 |
| iPTH (pmolL) | 22.7 [14.9;35.4] | 25.7 [14.3;36.4] | 0.23 |
| 25-hydroxy-vitamin D (nmol/L) | 28.9 [20.9;41.2] | 37.4 [26.4;48.7] | <0.001 |
| 1-25-hydroxy-vitamin D (pmol/L) | 13.6 [9.72;19.9] | 13.8 [9.31;22.3] | 0.54 |
| Treatments | |||
| Antihypertensive (%): | 214 (90.3) | 159 (67.1) | <0.001 |
| ACEI | 66 (27.8) | 41 (17.3) | 0.008 |
| ARBs | 111 (46.8) | 54 (22.8) | <0.001 |
| Diuretics (%) | 128 (54) | 45 (19) | <0.001 |
| Statins (%) | 137 (57.8) | 110 (46.4) | 0.017 |
| Phosphate binders (%): | 198 (83.5) | 189 (79.7) | 0.343 |
| Binders without Ca | 126 (53.2) | 138(58.2) | 0.309 |
| Binders with Ca | 42 (47.2) | 40 (47.1) | 1 |
| Cae intake (binders) (gr/day) | 1.5 [1;2] | 1.65 [1;3] | 0.027 |
| Calcitriol/Paricalcitol (%) | 97 (40.9) | 122 (51.5) | 0.027 |
| Calcifedol /%) | |||
| Cholecalciferol (%) | 27 (11.4) | 8 (3.38) | 0.002 |
| Cinacalcet (%) | 11(4.64) | 8 (3.38) | 0.640 |
| Antiplatelet drugs (%): | 27 (24.1) | 68 (28.7) | 0.297 |
| ESA | 181(76.4) | 198 (83.5) | 0.066 |
| Renal transplantation centre (%) | 88 (37.1) | 62 (26.2) | 0.014 |
| Plaque presence (%) | 123 (51.9) | 143 (60.3) | 0.08 |
| Number of territories with plaque | 2 [1.0;3.0] | 2 [1.0;3.0] | 0.285 |
| cIMT | 0.65 [0.56;0.79] | 0.70 [0.6;0.84] | 0.009 |
| Ankle-Brachial index (%) | |||
| ABI | 37 (15.7) | 23 (9.91) | 0.08 |
| ABI >0.9-<1.4 | 175 (74.5) | 144 (62.1) | 0.005 |
| ABI | 23 (9.79) | 65 (28) | <0.001 |
Data are presented as median [interquartile range], mean (standard deviation) or n(%).
a Peritoneal dialysis
b Hemodialysis
c Angiotensin converting enzyme inhibitors
d Angiotensin II receptor blockers
e Calcium
f Erythropoiesis stmulating agents
g Common carotid artery intima media thickness
Main Baseline characteristics of patients with 2-years follow-up according to dialysis modality.
| PD | HD | p | |
|---|---|---|---|
| (n = 82) | (n = 85) | ||
| Males (%) | 47 (57.3) | 48 (52.2) | 0.6 |
| Age (years) | 53 [42.5;63] | 55 [44.8;64] | 0.39 |
| Smoker (former/current) (%) | 49 (59.8) | 48 (52.2) | 0.9 |
| Diabetes (%) | 14 (17.1) | 14 (15.2) | 0.9 |
| 75 (91.5) | 79 (86) | 0.359 | |
| 58 (70.7) | 55 (59.8) | 0.176 | |
| Etiology of renal disease (%): | 0.670 | ||
| Diabetic nephropathy | 7 (8.54) | 8 (8.7) | |
| Vascular disease | 8 (9.76) | 13 (14.1) | |
| Others | 67 (81.7) | 71 (77.2) | |
| Dialysis time (months) | 10.5 [4.46;19.2] | 11.5 [5.82;25.8] | 0.131 |
| Body mass index (kg/m2) | 26.4 [23.3;28.4] | 26.1 [23;4.32.2] | 0.446 |
| Systolic Blood Pressure (mmHg) | 145 (24.4) | 138 (21.8) | 0.03 |
| Diastolic Blood Pressure (mm Hg) | 87.5 (12.2) | 78.8 (13.3) | <0.001 |
| Pulse Pressure (mmHg) | 56 [44;69] | 56.5 [47;70.2] | 0.579 |
| Serum glucose (mmol/L) | 5.16 [4.72;5.61] | 5.23 [4.55;6.05] | 0.931 |
| Urea (mmol/L) | 22.11 (6.76) | 20.31 (6.13) | 0.053 |
| Creatinine (μmol/L) | 596.7 [468.5;792.1] | 676.3 [583.4;837.2] | 0.815 |
| Total colesterol (mmol/L) | 4.75 [4.2;5.43] | 3.9 [3.2;4.45] | 0.258 |
| HDL-cholesterol (mmol/L) | 1.21 [1;1.52] | 1.1 [0.88;1.21] | 0.005 |
| LDL-cholesterol (mmol/L) | 3.46 [2.28;3.05] | 3.36 [2.56;4.4] | <0.001 |
| Triglycerides (mmol/L) | 1.53 [1.09;2.02] | 1.48 [1.13;1.94] | 0.940 |
| Serum uric acid (μmol/L) | 350.4 (72.6) | 369.4 (70.78) | 0.093 |
| hs C-Reactive Protein (nmol/L) | 26.28 [10;61.24] | 24 [10.47;62.48] | 0.815 |
| Albumin (mol/L) | 0.59 [0.53;0.62] | 0.59 [0.54;0.64] | 0.471 |
| Hemoglobin (mmol/L) | 7.24 (0.80) | 6.82 (0.84) | 0.002 |
| Corrected calcium (mmol/L) | 2.32 [2.22;2.4] | 2.25 [2.16;2.32] | 0.031 |
| Phosphate (mmol/L) | 1.52[1.32;1.81] | 1.55 [1.29;1.81] | 0.965 |
| iPTH (pmolL) | 21.1 [15.48;34.25] | 26.51 [16.2;41] | 0.182 |
| 25-hydroxy-vitamin D (nmol/L) | 30.5 [21.75;43.75] | 35.5 [27;48] | 0.014 |
| 1-25-hydroxy-vitamin D (pmol/L) | 15.45 [10.3;22.7] | 14.4 [10.15;25.75] | 0.862 |
| Treatments | |||
| Antihypertensive (%): | 72 (87.8) | 60 (65.2) | 0.001 |
| ACEI | 20 (24.4) | 15 (16.3) | 0.255 |
| ARBs | 37 (45.1) | 25 (27.2) | 0.021 |
| Diuretics (%) | 27 (32.6) | 28 (32.9) | 0.837 |
| Statins (%) | 48 (58.3) | 50 (54.3) | 0.687 |
| Phosphate binders (%): | 66 (80.5) | 68 (73.9) | 0.396 |
| Binders without Ca | 38 (46.3) | 48(52.2) | 0.538 |
| Binders with Ca | 42 (47.2) | 40 (47.1) | 1 |
| Cae intake (binders) (gr/day) | 1 [1;1.5] | 1.5 [1;2.5] | 0.03 |
| Calcitriol/Paricalcitol (%) | 34 (41.5) | 44 (47.8) | 0.490 |
| Calcifedol /%) | 8 (9.76) | 5 (5.43) | 0.428 |
| Cholecalciferol (%) | 2 (2.44) | 4 (4.35) | 0.685 |
| Cinacalcet (%) | 18 (22) | 24 (26.1) | 0.646 |
| Antiplatelet drugs (%): | 22 (26.8) | 27 (29.3) | 0.842 |
| ESA | 62 (75.6) | 77 (83.7) | 0.255 |
| Renal transplantation centre (%) | 27 (32.9) | 20 (21.7) | 0.137 |
| Plaque presence (%) | 44 (53.7) | 53 (57.6) | 0.711 |
| Number of territories with plaque | 2 [1.0;2.0] | 2 [1.0;3.0] | 0.149 |
| cIMT | 0.65 [0.57;0.75] | 0.72 [0.62;0.86] | 0.005 |
| Ankle-Brachial index (%) | <0.001 | ||
| ABI | 10 (12.2) | 7 (7.78) | |
| ABI >0.9-<1.4 | 66 (80.5) | 55 (61.1) | |
| ABI | 6 (7.32) | 21 (31.1) |
Data are presented as median [interquartile range], mean (standard deviation) or n (%).
a Peritoneal dialysis
b Hemodialysis
c Angiotensin converting enzyme inhibitors
d Angiotensin II receptor blockers
e Calcium
f Erythropoiesis stimulating agents
g Common carotid artery intima media thickness
Main Baseline characteristics of patients with 2-years follow-up according to dialysis modality.
| AVD | Non AVD progression | p | |
|---|---|---|---|
| (n = 89) | (n = 85) | ||
| Males (%) | 50 (56.2) | 45 (52.9) | 0.78 |
| Age (years) | 57 [48;65] | 50 [39;62] | 0.004 |
| Smoker (former/current) (%) | 53 (59.6) | 44 (51.8) | 0.38 |
| Diabetes (%) | 20 (22.5) | 8 (9.41) | 0.033 |
| Hypertension (%) | 79 (88.8) | 75 (88.2) | 1 |
| Dyslipidemia (%) | 59 (66.3) | 54 (63.5) | 0.824 |
| Etiology of renal disease (%): | 0.165 | ||
| Diabetic nephropathy | 25 (10.5) | 27 (11.4) | |
| Vascular disease | 23 (9.7) | 29 (12.2) | |
| Others | 69 (77.5) | 69 (81.2) | |
| Dialysis time (months) | 10.2 [4.4;23.2] | 11.8 [6.47;22.5] | 0.27 |
| Body mass index (kg/m2) | 27 [23.6;30.7] | 26.1 [23.1;28.8] | 0.156 |
| Systolic Blood Pressure (mmHg) | 142 (24.3) | 141 (24.3) | 0.735 |
| Diastolic Blood Pressure (mm Hg) | 82 (13.5) | 83.9 (13.5) | 0.343 |
| Pulse Pressure (mmHg) | 60 [44;74] | 56 [45;66] | 0.326 |
| Serum glucose (mmol/L) | 5.18 [4.54;6.10] | 5.05 [4.49;5.66] | 0.157 |
| Urea (mmol/L) | 18.3 (5.25) | 18.3 (5.21) | 0.984 |
| Creatinine (μmol/L) | 610 [486.2;797.4] | 662.1 [557.8;839.8] | 0.089 |
| Total colesterol (mmol/L) | 4.14 [3.63;4.89] | 4.45 [3.57;5.33] | 0.258 |
| HDL-cholesterol (mmol/L) | 1.10 [0.93;1.39] | 1.16 [0.96;1.37] | 0.561 |
| LDL-cholesterol (mmol/L) | 2.30 [1.85;2.82] | 2.61 [1.81;2.98] | 0.264 |
| Triglycerides (mmol/L) | 1.51 [1.11;2.10] | 1.38 [1.07;1.92] | 0.528 |
| Serum uric acid (μmol/L) | 370.5 (72.6) | 350.4 (70.8) | 0.084 |
| hs C-Reactive Protein (nmol/L) | 37.7 [13.8;65.9] | 18.5 [8.4;54.2] | 0.04 |
| Albumin (mol/L) | 0.59 [0.0.53;0.63] | 0.59 [0.54;0.62] | 0.613 |
| Hemoglobin (mmol/L) | 7 (0.95) | 7 (0.80) | 0.962 |
| Corrected calcium (mmol/L) | 2.31 [2.19;2.4] | 2.26 [2.12;2.37] | 0.419 |
| Phosphate (mmol/L) | 1.52 [1.26;1.81] | 1.55 [1.36;1.84] | 0.292 |
| iPTH (pmolL) | 24.7 [15.9;38.1] | 23.3 [15.27;36.7] | 0.586 |
| 25-hydroxy-vitamin D (nmol/L) | 30.9 [22.8;42.9] | 36.4 [26.7;48.7] | 0.043 |
| 1-25-hydroxy-vitamin D (pmol/L) | 14.9 [10.0;24.5] | 13.6 [9.7;22.3] | 0.602 |
| Treatments | |||
| Antihypertensive (%): | 68 (76.4) | 64 (75.3) | 1 |
| ACEI | 18 (20.2) | 17 (20) | 1 |
| ARBs | 29 (32.6) | 33 (38.8) | 0.483 |
| Diuretics (%) | 27 (32.6) | 28 (32.9) | 0.837 |
| Statins (%) | 51 (57.3) | 47 (55.3) | 0.9 |
| Phosphate binders (%): | 68 (76.4) | 66 (77.6) | 0.98 |
| Binders without Ca | 39 (43.8) | 47 (55.3) | 0.173 |
| Binders with Ca | 42 (47.2) | 40 (47.1) | 1 |
| Ca | 1 [1;1.5] | 1.5 [1;2.5] | |
| Calcitriol/Paricalcitol (%) | 45 (50.6) | 33 (38.8) | 0.16 |
| Calcifedol /%) | 9 (10.1) | 4 (4.71) | 0.286 |
| Cholecalciferol (%) | 3 (3.37) | 3 (3.53) | 1 |
| Cinacalcet (%) | 19 (21.3) | 23 (27.1) | 0.482 |
| Antiplatelet drugs (%): | 27 (30.3) | 22 (25.9) | 0.628 |
| ESA | 66 (74.2) | 73 (85.9) | 0.082 |
| Renal transplantation centre (%) | 22 (24.7) | 25 (29.4) | 0.599 |
| Plaque at baseline (%) | 64 (71.9) | 33 (33.8) | <0.001 |
| Number of territories with plaque | 2 [1.0;3.0] | 2 [1.0;3.0] | 0.398 |
| cIMT | 0.73 [0.65;0.89] | 0.64 [0.56;0.74] | <0.001 |
| Ankle-Brachial index (%) | |||
| ABI | 11 (12.5) | 6 (7.14) | 0.357 |
| ABI >0.9-<1.4 | 57 (64.8) | 64 (76.2) | 0.141 |
| ABI | 20 (22.7) | 14 (16.7) | 0.420 |
Data are presented as median [interquartile range], mean (standard deviation) or n (%).
a Atheromatous vascular disease
b Angiotensin converting enzyme inhibitors
c Angiotensin II receptor blockers
d Calcium
e Erythropoiesis stimulating agents
f Common carotid artery intima media thickness