Literature DB >> 29953560

Correction: The modality of dialysis does not influence atheromatous vascular disease progression or cardiovascular outcomes in dialysis patients without previous cardiovascular disease.

Mercè Borràs Sans, Miguel Pérez-Fontán, Montserrat Martinez-Alonso, Auxiliadora Bajo, Àngels Betriu, José M Valdivielso, Elvira Fernández.   

Abstract

[This corrects the article DOI: 10.1371/journal.pone.0186921.].

Entities:  

Year:  2018        PMID: 29953560      PMCID: PMC6023218          DOI: 10.1371/journal.pone.0200226

Source DB:  PubMed          Journal:  PLoS One        ISSN: 1932-6203            Impact factor:   3.240


There are errors in the “Hemoglobin (mmol/L)” values in Table 1, Table 2 and Table 3. Please see the corrected tables here.
Table 1

Main Baseline characteristics according to dialysis modality.

PDa patientsHDb patientsp
(n = 237)(n = 237)
Males (%)137 (58)146 (61.8)0.45
Age (years)52 [42;63]55 [43;63]0.11
Smoker (former/current) (%)135 (57)137 (58)0.92
Diabetes (%)43 (18.1)43 (18.1)1
Hypertension (%)219 (92.4)199 (84)0.007
Dyslipidemia (%)153 (64.6)123 (47.7)<0.001
Etiology of renal disease (%):0.670
Diabetic nephropathy25 (10.5)27 (11.4)
Vascular disease23 (9.7)29 (12.2)
Others189 (79.7)181 (76.4)
Dialysis time (months)13.7 [6.2;28.9]14.3 [6.41;28.6]0.91
Body mass index (kg/m2)26.4 [23.3;29.2]25.3 [23;28.6]0.23
Systolic Blood Pressure (mmHg)140 [129;159]135 [120;151]0.001
Diastolic Blood Pressure (mm Hg)83 [77;94]80 [70;88]<0.001
Pulse Pressure (mmHg)56 [45;69]55 [46;63]0.53
Serum glucose (mmol/L)5.05 [2.96;6.10]5.05 [4.56;6.10]0.838
Urea (mmol/L)21.5 [17.6;25.8]20.8 [15.8;25]0.07
Creatinine (μmol/L)682.5 [519.8;884]727.5 [574.6;884]0.1
Total colesterol (mmol/L)4.58 [3.99;5.20]3.91 [3.37;4.53]<0.001
HDL-cholesterol (mmol/L)1.22 [1.01;1.48]1.09 [0.90;1.29]<0.001
LDL-cholesterol (mmol/L)2.66 [2.07;5.15]2.07 [1.63;2.64]<0.001
Triglycerides (mmol/L)1.34 [1.07;1.87]1.41 [1.03;1.92]0.75
Serum uric acid (μmol/L)345.1 [303.4;401.6]362.9 [321.3;425.4]0.006
hs C-Reactive Protein (nmol/L)19 [8.95;49.9]22.47 [10.09;58.66]0.23
Albumin (mol/L)0.59 [0.54;0.62]0.59 [0.54;0.64]0.025
Hemoglobin (mmol/L)7.2 [7.01;8.01]7.26 [6.70;7.76]<0.001
Corrected calcium (mmol/L)2.3 [2.20;2.42]2.26 [2.16;2.36]<0.001
Phosphate (mmol/L)1.6 [1.35;1.84]1.54 [1.25;1.79]0.035
iPTH (pmolL)22.7 [14.9;35.4]25.7 [14.3;36.4]0.23
25-hydroxy-vitamin D (nmol/L)28.9 [20.9;41.2]37.4 [26.4;48.7]<0.001
1-25-hydroxy-vitamin D (pmol/L)13.6 [9.72;19.9]13.8 [9.31;22.3]0.54
Treatments
Antihypertensive (%):214 (90.3)159 (67.1)<0.001
ACEIc (%)66 (27.8)41 (17.3)0.008
ARBsd (%)111 (46.8)54 (22.8)<0.001
Diuretics (%)128 (54)45 (19)<0.001
Statins (%)137 (57.8)110 (46.4)0.017
Phosphate binders (%):198 (83.5)189 (79.7)0.343
Binders without Cae (%)126 (53.2)138(58.2)0.309
Binders with Cae (%)42 (47.2)40 (47.1)1
Cae intake (binders) (gr/day)1.5 [1;2]1.65 [1;3]0.027
Calcitriol/Paricalcitol (%)97 (40.9)122 (51.5)0.027
Calcifedol /%)
Cholecalciferol (%)27 (11.4)8 (3.38)0.002
Cinacalcet (%)11(4.64)8 (3.38)0.640
Antiplatelet drugs (%):27 (24.1)68 (28.7)0.297
ESAf(%)181(76.4)198 (83.5)0.066
Renal transplantation centre (%)88 (37.1)62 (26.2)0.014
Plaque presence (%)123 (51.9)143 (60.3)0.08
Number of territories with plaque2 [1.0;3.0]2 [1.0;3.0]0.285
cIMTg (mm)0.65 [0.56;0.79]0.70 [0.6;0.84]0.009
Ankle-Brachial index (%)
ABI < 0.937 (15.7)23 (9.91)0.08
ABI >0.9-<1.4175 (74.5)144 (62.1)0.005
ABI > 1.423 (9.79)65 (28)<0.001

Data are presented as median [interquartile range], mean (standard deviation) or n(%).

a Peritoneal dialysis

b Hemodialysis

c Angiotensin converting enzyme inhibitors

d Angiotensin II receptor blockers

e Calcium

f Erythropoiesis stmulating agents

g Common carotid artery intima media thickness

Table 2

Main Baseline characteristics of patients with 2-years follow-up according to dialysis modality.

PDa patientsHDb patientsp
(n = 82)(n = 85)
Males (%)47 (57.3)48 (52.2)0.6
Age (years)53 [42.5;63]55 [44.8;64]0.39
Smoker (former/current) (%)49 (59.8)48 (52.2)0.9
Diabetes (%)14 (17.1)14 (15.2)0.9
Hypertension (%)75 (91.5)79 (86)0.359
Dyslipidemia (%)58 (70.7)55 (59.8)0.176
Etiology of renal disease (%):0.670
Diabetic nephropathy7 (8.54)8 (8.7)
Vascular disease8 (9.76)13 (14.1)
Others67 (81.7)71 (77.2)
Dialysis time (months)10.5 [4.46;19.2]11.5 [5.82;25.8]0.131
Body mass index (kg/m2)26.4 [23.3;28.4]26.1 [23;4.32.2]0.446
Systolic Blood Pressure (mmHg)145 (24.4)138 (21.8)0.03
Diastolic Blood Pressure (mm Hg)87.5 (12.2)78.8 (13.3)<0.001
Pulse Pressure (mmHg)56 [44;69]56.5 [47;70.2]0.579
Serum glucose (mmol/L)5.16 [4.72;5.61]5.23 [4.55;6.05]0.931
Urea (mmol/L)22.11 (6.76)20.31 (6.13)0.053
Creatinine (μmol/L)596.7 [468.5;792.1]676.3 [583.4;837.2]0.815
Total colesterol (mmol/L)4.75 [4.2;5.43]3.9 [3.2;4.45]0.258
HDL-cholesterol (mmol/L)1.21 [1;1.52]1.1 [0.88;1.21]0.005
LDL-cholesterol (mmol/L)3.46 [2.28;3.05]3.36 [2.56;4.4]<0.001
Triglycerides (mmol/L)1.53 [1.09;2.02]1.48 [1.13;1.94]0.940
Serum uric acid (μmol/L)350.4 (72.6)369.4 (70.78)0.093
hs C-Reactive Protein (nmol/L)26.28 [10;61.24]24 [10.47;62.48]0.815
Albumin (mol/L)0.59 [0.53;0.62]0.59 [0.54;0.64]0.471
Hemoglobin (mmol/L)7.24 (0.80)6.82 (0.84)0.002
Corrected calcium (mmol/L)2.32 [2.22;2.4]2.25 [2.16;2.32]0.031
Phosphate (mmol/L)1.52[1.32;1.81]1.55 [1.29;1.81]0.965
iPTH (pmolL)21.1 [15.48;34.25]26.51 [16.2;41]0.182
25-hydroxy-vitamin D (nmol/L)30.5 [21.75;43.75]35.5 [27;48]0.014
1-25-hydroxy-vitamin D (pmol/L)15.45 [10.3;22.7]14.4 [10.15;25.75]0.862
Treatments
Antihypertensive (%):72 (87.8)60 (65.2)0.001
ACEIc (%)20 (24.4)15 (16.3)0.255
ARBsd (%)37 (45.1)25 (27.2)0.021
Diuretics (%)27 (32.6)28 (32.9)0.837
Statins (%)48 (58.3)50 (54.3)0.687
Phosphate binders (%):66 (80.5)68 (73.9)0.396
Binders without Cae (%)38 (46.3)48(52.2)0.538
Binders with Cae (%)42 (47.2)40 (47.1)1
Cae intake (binders) (gr/day)1 [1;1.5]1.5 [1;2.5]0.03
Calcitriol/Paricalcitol (%)34 (41.5)44 (47.8)0.490
Calcifedol /%)8 (9.76)5 (5.43)0.428
Cholecalciferol (%)2 (2.44)4 (4.35)0.685
Cinacalcet (%)18 (22)24 (26.1)0.646
Antiplatelet drugs (%):22 (26.8)27 (29.3)0.842
ESAf (%)62 (75.6)77 (83.7)0.255
Renal transplantation centre (%)27 (32.9)20 (21.7)0.137
Plaque presence (%)44 (53.7)53 (57.6)0.711
Number of territories with plaque2 [1.0;2.0]2 [1.0;3.0]0.149
cIMTg (mm)0.65 [0.57;0.75]0.72 [0.62;0.86]0.005
Ankle-Brachial index (%)<0.001
ABI <0.910 (12.2)7 (7.78)
ABI >0.9-<1.466 (80.5)55 (61.1)
ABI > 1.46 (7.32)21 (31.1)

Data are presented as median [interquartile range], mean (standard deviation) or n (%).

a Peritoneal dialysis

b Hemodialysis

c Angiotensin converting enzyme inhibitors

d Angiotensin II receptor blockers

e Calcium

f Erythropoiesis stimulating agents

g Common carotid artery intima media thickness

Table 3

Main Baseline characteristics of patients with 2-years follow-up according to dialysis modality.

AVDa progressionNon AVD progressionp
(n = 89)(n = 85)
Males (%)50 (56.2)45 (52.9)0.78
Age (years)57 [48;65]50 [39;62]0.004
Smoker (former/current) (%)53 (59.6)44 (51.8)0.38
Diabetes (%)20 (22.5)8 (9.41)0.033
Hypertension (%)79 (88.8)75 (88.2)1
Dyslipidemia (%)59 (66.3)54 (63.5)0.824
Etiology of renal disease (%):0.165
Diabetic nephropathy25 (10.5)27 (11.4)
Vascular disease23 (9.7)29 (12.2)
Others69 (77.5)69 (81.2)
Dialysis time (months)10.2 [4.4;23.2]11.8 [6.47;22.5]0.27
Body mass index (kg/m2)27 [23.6;30.7]26.1 [23.1;28.8]0.156
Systolic Blood Pressure (mmHg)142 (24.3)141 (24.3)0.735
Diastolic Blood Pressure (mm Hg)82 (13.5)83.9 (13.5)0.343
Pulse Pressure (mmHg)60 [44;74]56 [45;66]0.326
Serum glucose (mmol/L)5.18 [4.54;6.10]5.05 [4.49;5.66]0.157
Urea (mmol/L)18.3 (5.25)18.3 (5.21)0.984
Creatinine (μmol/L)610 [486.2;797.4]662.1 [557.8;839.8]0.089
Total colesterol (mmol/L)4.14 [3.63;4.89]4.45 [3.57;5.33]0.258
HDL-cholesterol (mmol/L)1.10 [0.93;1.39]1.16 [0.96;1.37]0.561
LDL-cholesterol (mmol/L)2.30 [1.85;2.82]2.61 [1.81;2.98]0.264
Triglycerides (mmol/L)1.51 [1.11;2.10]1.38 [1.07;1.92]0.528
Serum uric acid (μmol/L)370.5 (72.6)350.4 (70.8)0.084
hs C-Reactive Protein (nmol/L)37.7 [13.8;65.9]18.5 [8.4;54.2]0.04
Albumin (mol/L)0.59 [0.0.53;0.63]0.59 [0.54;0.62]0.613
Hemoglobin (mmol/L)7 (0.95)7 (0.80)0.962
Corrected calcium (mmol/L)2.31 [2.19;2.4]2.26 [2.12;2.37]0.419
Phosphate (mmol/L)1.52 [1.26;1.81]1.55 [1.36;1.84]0.292
iPTH (pmolL)24.7 [15.9;38.1]23.3 [15.27;36.7]0.586
25-hydroxy-vitamin D (nmol/L)30.9 [22.8;42.9]36.4 [26.7;48.7]0.043
1-25-hydroxy-vitamin D (pmol/L)14.9 [10.0;24.5]13.6 [9.7;22.3]0.602
Treatments
Antihypertensive (%):68 (76.4)64 (75.3)1
ACEIb (%)18 (20.2)17 (20)1
ARBsc (%)29 (32.6)33 (38.8)0.483
Diuretics (%)27 (32.6)28 (32.9)0.837
Statins (%)51 (57.3)47 (55.3)0.9
Phosphate binders (%):68 (76.4)66 (77.6)0.98
Binders without Cad (%)39 (43.8)47 (55.3)0.173
Binders with Cad (%)42 (47.2)40 (47.1)1
Cad intake (binders) (gr/day)1 [1;1.5]1.5 [1;2.5]
Calcitriol/Paricalcitol (%)45 (50.6)33 (38.8)0.16
Calcifedol /%)9 (10.1)4 (4.71)0.286
Cholecalciferol (%)3 (3.37)3 (3.53)1
Cinacalcet (%)19 (21.3)23 (27.1)0.482
Antiplatelet drugs (%):27 (30.3)22 (25.9)0.628
ESAe (%)66 (74.2)73 (85.9)0.082
Renal transplantation centre (%)22 (24.7)25 (29.4)0.599
Plaque at baseline (%)64 (71.9)33 (33.8)<0.001
Number of territories with plaque2 [1.0;3.0]2 [1.0;3.0]0.398
cIMTf (mm)0.73 [0.65;0.89]0.64 [0.56;0.74]<0.001
Ankle-Brachial index (%)
ABI <0.911 (12.5)6 (7.14)0.357
ABI >0.9-<1.457 (64.8)64 (76.2)0.141
ABI > 1.420 (22.7)14 (16.7)0.420
Dialysis modality:0.437
Hemodialysis44 (49.4)48 (56.5)
Peritoneal dialysis45 (50.6)37 (43.5)

Data are presented as median [interquartile range], mean (standard deviation) or n (%).

a Atheromatous vascular disease

b Angiotensin converting enzyme inhibitors

c Angiotensin II receptor blockers

d Calcium

e Erythropoiesis stimulating agents

f Common carotid artery intima media thickness

Data are presented as median [interquartile range], mean (standard deviation) or n(%). a Peritoneal dialysis b Hemodialysis c Angiotensin converting enzyme inhibitors d Angiotensin II receptor blockers e Calcium f Erythropoiesis stmulating agents g Common carotid artery intima media thickness Data are presented as median [interquartile range], mean (standard deviation) or n (%). a Peritoneal dialysis b Hemodialysis c Angiotensin converting enzyme inhibitors d Angiotensin II receptor blockers e Calcium f Erythropoiesis stimulating agents g Common carotid artery intima media thickness Data are presented as median [interquartile range], mean (standard deviation) or n (%). a Atheromatous vascular disease b Angiotensin converting enzyme inhibitors c Angiotensin II receptor blockers d Calcium e Erythropoiesis stimulating agents f Common carotid artery intima media thickness
  1 in total

1.  The modality of dialysis does not influence atheromatous vascular disease progression or cardiovascular outcomes in dialysis patients without previous cardiovascular disease.

Authors:  Mercè Borràs Sans; Miguel Pérez-Fontán; Montserrat Martinez-Alonso; Auxiliadora Bajo; Àngels Betriu; José M Valdivielso; Elvira Fernández
Journal:  PLoS One       Date:  2017-11-02       Impact factor: 3.240

  1 in total

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