Pierfrancesco Franco1, Francesca Arcadipane1, Riccardo Ragona1, Adriana Lesca2, Elena Gallio3, Massimiliano Mistrangelo4, Elisabetta Trino1, Paola Cassoni5, Vincenzo Arena6, Massimo Baccega2, Patrizia Racca7, Riccardo Faletti8, Nadia Rondi9, Mario Morino4, Umberto Ricardi1. 1. a Department of Oncology - Radiation Oncology , University of Turin , Turin , Italy. 2. b Nuclear Medicine Unit, Department of Radiology , AOU Città della Salute e della Scienza , Turin , Italy. 3. c Medical Physics Unit, Department of Radiology , AOU Città della Salute e della Scienza , Turin , Italy. 4. d Department of Surgical Sciences , University of Turin , Turin , Italy. 5. e Department of Medical Sciences, Pathology Unit , University of Torino , Turin , Italy. 6. f Department of Nuclear Medicine , Center for Diagnostic Imaging (IRMET) , Turin , Italy. 7. g Department of Medical Oncology , Oncological Centre for Gastrointestinal Neoplasms , Turin , Italy. 8. h Radiology Unit, Department of Surgical Sciences , University of Turin , Turin , Italy. 9. i Department of Oncology, Radiation Oncology , AOU Città della Salute e della Scienza , Turin , Italy.
Abstract
PURPOSE: To investigate whether irradiated volume of pelvic active bone marrow (ACTBM) may predict decreased blood cells nadirs in anal cancer patients undergoing concurrent chemo-radiation. METHODS: Forty-four patients were analyzed and pelvic active bone marrow (ACTBM) was characterized employing 18FDG-PET. Dosimetric parameters on dose-volume histograms were correlated to nadirs with generalized linear modeling. RESULTS: ACTBM mean dose was significantly correlated to white blood cell (β = -1.338; 95%CI: -2.455/-0.221; p = 0.020), absolute neutrophil count (β = -1.651; 95%CI: -3.284/-0.183; p = 0.048), and platelets (β = -0.031; 95%CI: -0.057/-0.004; p = 0.024) nadirs. Other dosimetric parameters were found to be correlated (ACTBM-V10,-V20,-V30and-V40). CONCLUSIONS: 18FDG-PET is able to define active bone marrow and may predict for decreased blood cells count nadirs.
PURPOSE: To investigate whether irradiated volume of pelvic active bone marrow (ACTBM) may predict decreased blood cells nadirs in anal cancerpatients undergoing concurrent chemo-radiation. METHODS: Forty-four patients were analyzed and pelvic active bone marrow (ACTBM) was characterized employing 18FDG-PET. Dosimetric parameters on dose-volume histograms were correlated to nadirs with generalized linear modeling. RESULTS: ACTBM mean dose was significantly correlated to white blood cell (β = -1.338; 95%CI: -2.455/-0.221; p = 0.020), absolute neutrophil count (β = -1.651; 95%CI: -3.284/-0.183; p = 0.048), and platelets (β = -0.031; 95%CI: -0.057/-0.004; p = 0.024) nadirs. Other dosimetric parameters were found to be correlated (ACTBM-V10,-V20,-V30and-V40). CONCLUSIONS: 18FDG-PET is able to define active bone marrow and may predict for decreased blood cells count nadirs.
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