Literature DB >> 2995289

Hyperproduction and gene amplification of the epidermal growth factor receptor in squamous cell carcinomas.

J Hunts, M Ueda, S Ozawa, O Abe, I Pastan, N Shimizu.   

Abstract

Human squamous cell carcinoma tissue was screened to determine the epidermal growth factor (EGF) receptor level. In 9 out of 15 cases, increased EGF binding was observed relative to normal adjacent tissue. In two tissue samples (SCE1 and SCL1), amplification of the EGF receptor gene and increased mRNA level were also observed. In two other cases (SCE2 and SCL3), EGF receptor gene amplification did not occur. We propose that there is an alternative mechanism for EGF receptor hyperproduction, independent of gene content, active in these tissues. A possible role of EGF receptor hyperproduction is envisioned in human neoplasia.

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Year:  1985        PMID： 2995289

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


  31 in total

Review 1.  Monoclonal antibodies to epidermal growth factor receptors in studies of receptor structure and function.

Authors:  T Kawamoto; G H Sato; K Takahashi; M Nishi; S Taniguchi; J D Sato
Journal:  Cytotechnology       Date:  1990-05       Impact factor: 2.058

2.  Frequent mutation of the p53 gene in human esophageal cancer.

Authors:  M C Hollstein; R A Metcalf; J A Welsh; R Montesano; C C Harris
Journal:  Proc Natl Acad Sci U S A       Date:  1990-12       Impact factor: 11.205

3.  Expression of epidermal growth factor receptor in normal colorectal mucosa, adenoma, and carcinoma.

Authors:  K Koretz; P Schlag; P Möller
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1990

4.  Epidermal growth factor receptor on human thyroid neoplasms.

Authors:  H Masuda; A Sugenoya; S Kobayashi; Y Kasuga; F Iida
Journal:  World J Surg       Date:  1988-10       Impact factor: 3.352

5.  A phase I study of oral ZD 1839 given daily in patients with solid tumors: IND.122, a study of the Investigational New Drug Program of the National Cancer Institute of Canada Clinical Trials Group.

Authors:  G Goss; H Hirte; W H Miller; I A J Lorimer; D Stewart; G Batist; D A E Parolin; P Hanna; S Stafford; J Friedmann; W Walsh; S Mathews; L Douglas; L K Seymour
Journal:  Invest New Drugs       Date:  2005-03       Impact factor: 3.850

6.  Precise mapping of the EGF receptor gene on the human chromosome 7p12 using an improved fish technique.

Authors:  Y Wang; S Minoshima; N Shimizu
Journal:  Jpn J Hum Genet       Date:  1993-12

7.  Expression of growth factors and their receptors in human esophageal carcinomas: regulation of expression by epidermal growth factor and transforming growth factor alpha.

Authors:  K Yoshida; H Kuniyasu; W Yasui; Y Kitadai; T Toge; E Tahara
Journal:  J Cancer Res Clin Oncol       Date:  1993       Impact factor: 4.553

8.  A truncated, secreted form of the epidermal growth factor receptor is encoded by an alternatively spliced transcript in normal rat tissue.

Authors:  L A Petch; J Harris; V W Raymond; A Blasband; D C Lee; H S Earp
Journal:  Mol Cell Biol       Date:  1990-06       Impact factor: 4.272

9.  Proliferating cell nuclear antigen in breast lesions: correlation of c-erbB-2 oncoprotein and EGF receptor and its clinicopathological significance in breast cancer.

Authors:  P Shrestha; K Yamada; T Wada; S Maeda; M Watatani; M Yasutomi; H Takagi; M Mori
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1992

10.  Epidermal growth factor receptor expression on oral mucosa dysplastic epithelia and squamous cell carcinomas.

Authors:  M E Christensen; M H Therkildsen; B L Hansen; H Albeck; G N Hansen; P Bretlau
Journal:  Eur Arch Otorhinolaryngol       Date:  1992       Impact factor: 2.503
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