Environmental risk assessment of chronic arsenic in drinking water and prevalence of type-2 diabetes mellitus in Pakistan.

Chronic arsenic (As) unprotection in drinking water can lead to Type 2 Diabetes Mellitus (T2DM). The purpose of this study was to investigate the association between chronic As in drinking water and the prevalence of T2DM. A study was conducted in targeted urban areas of Peshawar city of KPK, Pakistan, where drinking water is heavily contaminated with chronic arsenic. Participants protected to arsenic were selected from Kohat city of KPK, Pakistan (where people consumed water that is free from As contamination) and treated as the control group. People with arsenic-related skin lesions were defined as participants unprotected to arsenic. T2DM was diagnosed using a glucometer following the fasting blood glucose ≥6.0 mmol L-1 from the WHO guideline. The common odds ratio for T2DM among participants unprotected to arsenic was <4. The Mantel-Haenszel weighted prevalence ratio with 95% of confidence interval for confounding factors were (age <4 m femininity <4 and body mass index >4). The results revealed that designated association were important. The findings suggested that unprotected chronic arsenic in drinking water may be a risk factor of T2DM.