Literature DB >> 2995255

Biphasic contraction of isolated guinea pig tracheal chains by superoxide radical.

Y Nishida, S Suzuki, T Miyamoto.   

Abstract

The effects of free radicals on the isolated tracheal chains from guinea pigs were examined in in vitro experiments. When isolated tracheal chains were exposed to the hypoxanthine plus xanthine oxidase system, biphasic contraction was observed. This contraction was prevented by adding superoxide dismutase. However, catalase, mannitol, and indomethacin were ineffective in preventing the contraction due to free radicals. The uric acid plus uricase system had no effect on tracheal muscle tension. These results suggest that superoxide radical contracts tracheal chains.

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Year:  1985        PMID： 2995255     DOI： 10.1007/bf00916281

Source DB:  PubMed          Journal:  Inflammation        ISSN： 0360-3997            Impact factor:   4.092


  8 in total

1.  Editorial: Superoxide radical and the bactericidal action of phagocytes.

Authors:  I Fridovich
Journal:  N Engl J Med       Date:  1974-03-14       Impact factor: 91.245

2.  Effect of free radicals on lymphocyte response to mitogens and rosette formation.

Authors:  Y Nishida; K Tanimoto; I Akaoka
Journal:  Clin Immunol Immunopathol       Date:  1981-06

3.  The effect of oxidant injury on the lymphoblastic transformation of human lymphocytes.

Authors:  A L Sagone; S Kamps; R Campbell
Journal:  Photochem Photobiol       Date:  1978 Oct-Nov       Impact factor: 3.421

4.  Complement and immunoglobulins stimulate superoxide production by human leukocytes independently of phagocytosis.

Authors:  I M Goldstein; D Roos; H B Kaplan; G Weissmann
Journal:  J Clin Invest       Date:  1975-11       Impact factor: 14.808

5.  Rat alveolar macrophages require NADPH for superoxide production in the respiratory burst. Effect of NADPH depletion by paraquat.

Authors:  H J Forman; J Nelson; A B Fisher
Journal:  J Biol Chem       Date:  1980-10-25       Impact factor: 5.157

6.  Enhancement of platelet function by superoxide anion.

Authors:  R I Handin; R Karabin; G J Boxer
Journal:  J Clin Invest       Date:  1977-05       Impact factor: 14.808

7.  Hydrogen peroxide contracts airway smooth muscle: a possible endogenous mechanism.

Authors:  R M Stewart; E K Weir; M R Montgomery; D E Niewoehner
Journal:  Respir Physiol       Date:  1981-09

8.  Evidence that the superoxide-generating system of human leukocytes is associated with the cell surface.

Authors:  I M Goldstein; M Cerqueira; S Lind; H B Kaplan
Journal:  J Clin Invest       Date:  1977-02       Impact factor: 14.808
  8 in total
  3 in total

1.  Platelet-activating factor relaxes ferret tracheal smooth muscle and reduces transepithelial potential difference in vitro.

Authors:  S E Webber; T Morikawa; J G Widdicombe
Journal:  Br J Pharmacol       Date:  1992-01       Impact factor: 8.739

2.  Does the xanthine-xanthine oxidase system alter contractile behaviour of vascular smooth muscle?

Authors:  V Lindner; H Heinle
Journal:  Pflugers Arch       Date:  1987-02       Impact factor: 3.657

3.  Effect of hydrogen peroxide on guinea-pig tracheal smooth muscle in vitro: role of cyclo-oxygenase and airway epithelium.

Authors:  K J Rhoden; P J Barnes
Journal:  Br J Pharmacol       Date:  1989-09       Impact factor: 8.739
  3 in total

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