Binbin Hong 1,2 , Yumei Wen 1 , Tianlei Ying 1 Show Affiliations »
Abstract
BACKGROUND: Hepatitis B virus (HBV) infection remains a global health problem. As "cure" for chronic hepatitis B is of current priority, hepatitis B immunoglobulin (HBIG) has been utilized for several decades to provide post-exposure prophylaxis. In recent years, a number of monoclonal antibodies (mAbs) targeting HBV have been developed and demonstrated with high affinity, specificity, and neutralizing potency. OBJECTIVE: HBV neutralizing antibodies may play a potentially significant role in the search for an HBV cure. In this review, we will summarize the recent progress in developing HBV-neutralizing antibodies, describing their characteristics and potential clinical applications. RESULTS AND CONCLUSION: HBV neutralizing antibodies could be a promising alternative in the prevention and treatment of HBV infection. More importantly, global collaboration and coordinated approaches are thus needed to facilitate the development of novel therapies for HBV infection. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
BACKGROUND: Hepatitis B virus (HBV) infection remains a global health problem. As "cure" for chronic hepatitis B is of current priority, hepatitis B immunoglobulin (HBIG) has been utilized for several decades to provide post-exposure prophylaxis. In recent years, a number of monoclonal antibodies (mAbs) targeting HBV have been developed and demonstrated with high affinity, specificity, and neutralizing potency. OBJECTIVE: HBV neutralizing antibodies may play a potentially significant role in the search for an HBV cure. In this review, we will summarize the recent progress in developing HBV -neutralizing antibodies, describing their characteristics and potential clinical applications. RESULTS AND CONCLUSION: HBV neutralizing antibodies could be a promising alternative in the prevention and treatment of HBV infection . More importantly, global collaboration and coordinated approaches are thus needed to facilitate the development of novel therapies for HBV infection . Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
Entities: Disease
Species
Keywords:
HBV cure; HbsAg; Hepatitis B virus; antibodies; infection; neutralizing antibody.
Mesh： See more »
Substances： See more »
Year: 2019
PMID： 29952267 DOI： 10.2174/1871526518666180628122400
Source DB: PubMed Journal: Infect Disord Drug Targets ISSN： 1871-5265