Tamayo Naka1,2, Kentaro Kohagura3,4, Masako Kochi2, Yusuke Ohya2,5. 1. Nishizaki Hospital, Itoman, Okinawa, Japan. 2. Department of Cardiovascular Medicine, Nephrology and Neurology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan. 3. Department of Cardiovascular Medicine, Nephrology and Neurology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan. kohagura@med.u-ryukyu.ac.jp. 4. Dialysis Unit, University Hospital of the Ryukyus, 207 Uehara, Nishihara-cho, Okinawa, Japan. kohagura@med.u-ryukyu.ac.jp. 5. Dialysis Unit, University Hospital of the Ryukyus, 207 Uehara, Nishihara-cho, Okinawa, Japan.
Abstract
INTRODUCTION: Hyponatremia is common among elderly patients. This study aimed to examine the prognostic value of hyponatremia among elderly residents in a geriatric facility. METHODS: We retrospectively examined the association between serum sodium levels and mortality among 118 residents (82% female, mean age 85.5 years) in a single geriatric health service facility. We defined hyponatremia as Na < 135 mEq/L. On the basis of single measurements of serum sodium at periodic examinations, the patients were divided into hyponatremia and non-hyponatremia groups. Multivariable Cox proportional hazards models were used to evaluate the effect of hyponatremia on mortality from May 2005 to April 2007. RESULTS: Thirty-three patients (28%) had hyponatremia. Over a 1-year follow-up period, the cumulative survival rate was significantly lower in patients with hyponatremia than in those without hyponatremia. In a multivariate analysis, including traditional risk factors for death, hyponatremia was associated with an increased mortality risk (adjusted hazard ratio 2.73; 95% confidence interval 1.01-5.16; p = 0.047). CONCLUSIONS: Hyponatremia is common and is a predictor of mortality in the near future among very elderly residents of a geriatric facility.
INTRODUCTION:Hyponatremia is common among elderly patients. This study aimed to examine the prognostic value of hyponatremia among elderly residents in a geriatric facility. METHODS: We retrospectively examined the association between serum sodium levels and mortality among 118 residents (82% female, mean age 85.5 years) in a single geriatric health service facility. We defined hyponatremia as Na < 135 mEq/L. On the basis of single measurements of serum sodium at periodic examinations, the patients were divided into hyponatremia and non-hyponatremia groups. Multivariable Cox proportional hazards models were used to evaluate the effect of hyponatremia on mortality from May 2005 to April 2007. RESULTS: Thirty-three patients (28%) had hyponatremia. Over a 1-year follow-up period, the cumulative survival rate was significantly lower in patients with hyponatremia than in those without hyponatremia. In a multivariate analysis, including traditional risk factors for death, hyponatremia was associated with an increased mortality risk (adjusted hazard ratio 2.73; 95% confidence interval 1.01-5.16; p = 0.047). CONCLUSIONS:Hyponatremia is common and is a predictor of mortality in the near future among very elderly residents of a geriatric facility.
Authors: Ewout J Hoorn; Fernando Rivadeneira; Joyce B J van Meurs; Gijsbertus Ziere; Bruno H Ch Stricker; Albert Hofman; Huibert A P Pols; Robert Zietse; André G Uitterlinden; M Carola Zillikens Journal: J Bone Miner Res Date: 2011-08 Impact factor: 6.741