BACKGROUND: Lectin-like oxidized low density lipoprotein receptor 1 (OLR1) locates within the area of chromosome 12p, which has been identified as the AD-susceptible region, and plays a role in lipid metabolism. Therefore, it has been suggested to be a good candidate gene for Alzheimer's disease (AD). Several SNPs within OLR1 have been reported to have association with AD among Caucasians. METHODS: We selected and genotyped three SNPs (rs1050283, rs1050286, rs17808009) in OLR1 to investigate its possible relationship with the onset of late-onset Alzheimer disease(LOAD) in 984 LOAD cases and 1,354 healthy controls among northern Han Chinese. RESULTS: No significant association was found between the OLR1 (rs1050283, rs1050286, rs17808009) polymorphisms and LOAD, even after adjustment for gender and age and stratification for apolipoprotein E (APOE) status. CONCLUSIONS: Our study showed that the SNPs (rs1050283, rs1050286, rs17808009) located in the 3'UTR of OLR1 may not involve in the mechanism of LOAD in Han Chinese population.
BACKGROUND: Lectin-like oxidized low density lipoprotein receptor 1 (OLR1) locates within the area of chromosome 12p, which has been identified as the AD-susceptible region, and plays a role in lipid metabolism. Therefore, it has been suggested to be a good candidate gene for Alzheimer's disease (AD). Several SNPs within OLR1 have been reported to have association with AD among Caucasians. METHODS: We selected and genotyped three SNPs (rs1050283, rs1050286, rs17808009) in OLR1 to investigate its possible relationship with the onset of late-onset Alzheimer disease(LOAD) in 984 LOAD cases and 1,354 healthy controls among northern Han Chinese. RESULTS: No significant association was found between the OLR1 (rs1050283, rs1050286, rs17808009) polymorphisms and LOAD, even after adjustment for gender and age and stratification for apolipoprotein E (APOE) status. CONCLUSIONS: Our study showed that the SNPs (rs1050283, rs1050286, rs17808009) located in the 3'UTR of OLR1 may not involve in the mechanism of LOAD in Han Chinese population.
Entities:
Keywords:
Alzheimer’s disease (AD); genetics; oxidized low density lipoprotein receptor 1(OLR1); polymorphism association study
Authors: D Larry Sparks; Richard J Kryscio; Marwan N Sabbagh; Donald J Connor; Lisa M Sparks; Carolyn Liebsack Journal: Curr Alzheimer Res Date: 2008-08 Impact factor: 3.498
Authors: Neha Patel; David Hoang; Nathan Miller; Sara Ansaloni; Qihong Huang; Jack T Rogers; Jeremy C Lee; Aleister J Saunders Journal: Mol Neurodegener Date: 2008-08-06 Impact factor: 14.195
Authors: Ava Faridi; Wen Yang; Hannah Gabrielle Kelly; Chuanyu Wang; Pouya Faridi; Anthony Wayne Purcell; Thomas P Davis; Pengyu Chen; Stephen J Kent; Pu Chun Ke Journal: Biomacromolecules Date: 2019-10-22 Impact factor: 6.978