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Literature DB >> 2995113

Inhibition of sarcolemmal Na, K, Mg ATPase from the guinea pig heart is not compatible with a homogeneous population of non-interacting ouabain receptors.

Abstract

The inhibition of sarcolemmal Na, K, Mg ATPase from the guinea pig heart by ouabain was evaluated with a coupled enzyme assay. Models of negative cooperativity and of two independent receptors fitted the inhibition data equally well. The analysis was not compatible with a homogeneous population of non-interacting ouabain receptors.

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Year: 1985 PMID： 2995113 DOI： 10.1007/bf01951701

Source DB: PubMed Journal: Experientia ISSN： 0014-4754

12 in total

1. Separation of vesicles of cardiac sarcolemma from vesicles of cardiac sarcoplasmic reticulum. Comparative biochemical analysis of component activities.

Authors: L R Jones; H R Besch; J W Fleming; M M McConnaughey; A M Watanabe
Journal: J Biol Chem Date: 1979-01-25 Impact factor: 5.157

2. Ouabain-receptor interactions in (Na+ + K+)-ATPase preparations. A contribution to the problem of nonlinear Scatchard plots.

Authors: E Erdmann; G Philipp
Journal: Biochim Biophys Acta Date: 1976-12-02

3. Protein measurement with the Folin phenol reagent.

Authors: O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal: J Biol Chem Date: 1951-11 Impact factor: 5.157

4. Ouabain-receptor interactions in (Na+ + K+)-ATPase preparations. II. Effect of cations and nucleotides on rate constants and dissociation constants.

Authors: E Erdmann; W Schoner
Journal: Biochim Biophys Acta Date: 1973-12-22

10. Cardiac glycoside receptors in cultured heart cells--II. Characterization of a high affinity and a low affinity binding site in heart muscle cells from neonatal rats.

Authors: K Werdan; B Wagenknecht; B Zwissler; L Brown; W Krawietz; E Erdmann
Journal: Biochem Pharmacol Date: 1984-06-15 Impact factor: 5.858

2 in total

1. The reaction of ouabain with the sodium pump of guinea-pig myocardium in relation to its inotropic effect.

Authors: F Ebner; M Korth; V Kühlkamp
Journal: J Physiol Date: 1986-10 Impact factor: 5.182

2. Factors influencing the onset of ouabain inhibition of Na,K-ATPase from guinea-pig myocardium.

Authors: F Ebner
Journal: Br J Pharmacol Date: 1990-10 Impact factor: 8.739

2 in total

Inhibition of sarcolemmal Na, K, Mg ATPase from the guinea pig heart is not compatible with a homogeneous population of non-interacting ouabain receptors.

1. Separation of vesicles of cardiac sarcolemma from vesicles of cardiac sarcoplasmic reticulum. Comparative biochemical analysis of component activities.

2. Ouabain-receptor interactions in (Na+ + K+)-ATPase preparations. A contribution to the problem of nonlinear Scatchard plots.

3. Protein measurement with the Folin phenol reagent.

4. Ouabain-receptor interactions in (Na+ + K+)-ATPase preparations. II. Effect of cations and nucleotides on rate constants and dissociation constants.

5. Two apparently different ouabain binding sites of (Na + -K + )-ATPase.

6. Possible involvement of cardiac Na+, K+-adenosine triphosphatase in the mechanism of action of cardiac glycosides.

7. Ouabain receptor in isolated adult dog heart myocytes.

8. CA2+-free perfusion of rat heart reveals a (Na+ + K+)ATPase form highly sensitive to ouabain.

9. Heterogeneity of ouabain specific binding sites and (Na+ + K+)-ATPase inhibition in microsomes from rat heart.

10. Cardiac glycoside receptors in cultured heart cells--II. Characterization of a high affinity and a low affinity binding site in heart muscle cells from neonatal rats.

1. The reaction of ouabain with the sodium pump of guinea-pig myocardium in relation to its inotropic effect.

2. Factors influencing the onset of ouabain inhibition of Na,K-ATPase from guinea-pig myocardium.