Literature DB >> 2995010

TSH and cAMP enhance expression of the myc proto-oncogene in cultured thyroid cells.

W H Dere, H Hirayu, B Rapoport.   

Abstract

The effect of TSH stimulation on cellular (c)-myc mRNA content in cultured thyroid cells was examined by Northern blot analysis. Polyadenylated mRNA was prepared from quiescent FRTL-5 rat thyroid cells and from cells stimulated by TSH for 8 h. A major 2.1 kilobase (kb) transcript was enhanced 5.5-fold by TSH. (Bu)2cAMP and forskolin each enhanced c-myc expression 2.7-fold. These data indicate that TSH, via cAMP as a second messenger, can regulate expression of a cellular oncogene in a non-neoplastic, specific target cell.

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Year:  1985        PMID： 2995010     DOI： 10.1210/endo-117-5-2249

Source DB:  PubMed          Journal:  Endocrinology        ISSN： 0013-7227            Impact factor:   4.736


  9 in total

1.  Demonstration of the production and physiological role of insulin-like growth factor II in rat thyroid follicular cells in culture.

Authors:  R M Maciel; A C Moses; G Villone; D Tramontano; S H Ingbar
Journal:  J Clin Invest       Date:  1988-11       Impact factor: 14.808

2.  c-myc, c-H-ras, and IP3 elevation in 18:2 n-6 dependent proliferation of lung cells.

Authors:  S Usha; A Balakrishnan
Journal:  In Vitro Cell Dev Biol Anim       Date:  1997 Jul-Aug       Impact factor: 2.416

3.  Platelet-derived growth factor-stimulated c-myc RNA accumulation in MG-63 human osteosarcoma cells is independent of both protein kinase A and protein kinase C.

Authors:  K K Frick; C D Scher
Journal:  Mol Cell Biol       Date:  1990-01       Impact factor: 4.272

4.  Relationship between proliferation and cell cycle-dependent Ca2+ influx induced by a combination of thyrotropin and insulin-like growth factor-I in rat thyroid cells.

Authors:  K Takada; N Amino; H Tada; K Miyai
Journal:  J Clin Invest       Date:  1990-11       Impact factor: 14.808

5.  [Growth and invasion of differentiated thyroid gland carcinoma: importance of signal transduction].

Authors:  T Hölting; O Y Duh; O H Clark; C Herfarth
Journal:  Langenbecks Arch Chir       Date:  1995

6.  Structure and expression of nuclear oncogenes in multi-stage thyroid tumorigenesis.

Authors:  F S Wyllie; N R Lemoine; E D Williams; D Wynford-Thomas
Journal:  Br J Cancer       Date:  1989-10       Impact factor: 7.640

7.  Structure and expression of c-myc and c-fos proto-oncogenes in thyroid carcinomas.

Authors:  P Terrier; Z M Sheng; M Schlumberger; M Tubiana; B Caillou; J P Travagli; P Fragu; C Parmentier; G Riou
Journal:  Br J Cancer       Date:  1988-01       Impact factor: 7.640

8.  Regulation of inhibitors of differentiation family proteins by thyroid-stimulating hormone in FRTL-5 thyroid cells.

Authors:  Young Suk Jo; Eun Suk Hwang; Ju Hee Lee; Yunhyeong Lee; Seul Young Kim; Yun-Sun Choi; Youn-Sun Bai; Jun Hwa Hong; Yun-Jeung Kim; Ihn-Suk Lee; So Young Rha; Heung-kyu Ro; Minho Shong
Journal:  J Korean Med Sci       Date:  2008-04       Impact factor: 2.153

9.  Expression of oncogenes in thyroid tumours: coexpression of c-erbB2/neu and c-erbB.

Authors:  R Aasland; J R Lillehaug; R Male; O Jøsendal; J E Varhaug; K Kleppe
Journal:  Br J Cancer       Date:  1988-04       Impact factor: 7.640
  9 in total

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