Zhenjie Mo1,2,3, Junfeng Ban1,2,3, Yan Zhang1,2,3, Youyun Du1,2,3, Yifeng Wen1,2,3, Xin Huang1,2,3, Qingchun Xie1,2,3, Lou Shen1,2,3, Shu Zhang1,2,3, Hong Deng1,2,3, Dongzhi Hou1,2,3, Yanzhong Chen1,2,3, Zhufen Lu1,2,3. 1. Guangdong Provincial Key Laboratory of Advanced Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, PR China. 2. Guangdong Provincial Engineering Center of Topical Precise Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, PR China. 3. R&D Team for Formulation Innovation, Guangdong Pharmaceutical University, Guangzhou, PR China.
Abstract
AIM: Nanostructured lipid carriers in-gel (NLCs-gel) were prepared to enhance and improve the ocular delivery of dexamethasone. Materials & methods: NLCs containing dexamethasone prepared by high-pressure homogenization were characterized and dispersed into thermosensitive gels (Pluronic F127 and F68 as gels material). In vitro drug release studies, ocular irritation tests, ex vivo corneal penetration and drug dynamics of NLCs and NLCs-gel were evaluated in aqueous humor. RESULTS: NLCs-gel exhibited a rapid sol-gel transition at 34.4°C and presented nano-sized, narrowly distributed particles. Corneal penetration studies revealed steady sustained drug release (Ritger-Peppas); NLCs-gel increased ocular bioavailability by prolonging precorneal retention time and improving corneal permeation. CONCLUSION: These findings suggest developing NLCs-gel for potential treatment of posterior segment eye diseases.
AIM: Nanostructured lipid carriers in-gel (NLCs-gel) were prepared to enhance and improve the ocular delivery of dexamethasone. Materials & methods: NLCs containing dexamethasone prepared by high-pressure homogenization were characterized and dispersed into thermosensitive gels (Pluronic F127 and F68 as gels material). In vitro drug release studies, ocular irritation tests, ex vivo corneal penetration and drug dynamics of NLCs and NLCs-gel were evaluated in aqueous humor. RESULTS: NLCs-gel exhibited a rapid sol-gel transition at 34.4°C and presented nano-sized, narrowly distributed particles. Corneal penetration studies revealed steady sustained drug release (Ritger-Peppas); NLCs-gel increased ocular bioavailability by prolonging precorneal retention time and improving corneal permeation. CONCLUSION: These findings suggest developing NLCs-gel for potential treatment of posterior segment eye diseases.
Authors: Eszter L Kiss; Szilvia Berkó; Attila Gácsi; Anita Kovács; Gábor Katona; Judit Soós; Erzsébet Csányi; Ilona Gróf; András Harazin; Mária A Deli; Mária Budai-Szűcs Journal: Pharmaceutics Date: 2019-12-14 Impact factor: 6.321
Authors: Shery Jacob; Anroop B Nair; Jigar Shah; Sumeet Gupta; Sai H S Boddu; Nagaraja Sreeharsha; Alex Joseph; Pottathil Shinu; Mohamed A Morsy Journal: Pharmaceutics Date: 2022-02-27 Impact factor: 6.321