Seyedehhamideh Razavi1, Alireza Partoazar2, Nasrin Takzaree3, Mahdi Fasihi-Ramandi4, Abas Bahador5, Mohammad H Darvishi1. 1. Nanobiotechnology Research Centre, Baqiyatallah University of Medical Sciences, Tehran, Iran. 2. Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran. 3. Anatomy Department, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. 4. Molecular Biology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. 5. Department of Microbiology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Abstract
AIM: Nanoethosomal formulation containing silver sulfadiazine (SSD) was used to reduce bacterial burden and healing time in burn injuries. MATERIALS & METHODS: Ethosomal formulations were characterized for their size, ζ-potential, morphology, drug encapsulation efficiency and in vitro release kinetics of SSD. RESULTS: The optimized nanoethosomal suspension with a size of 206.7 ± 1.18, and ζ-potential value of -67.3 ± 0.45 mV exhibited a high SSD encapsulation efficiency (92.03 ± 0.79%). Results of antimicrobial tests indicated SSD-loaded ethosome formulation led to a significant reduction of colony number. Histopathological results demonstrated a wound contraction rate of 96.83% for the group treated with SSD ethosomal gel while untreated group showed 59.41%. CONCLUSION: The SSD ethogels promotes the therapeutic effect of SSD for burn treatment.
AIM: Nanoethosomal formulation containing silver sulfadiazine (SSD) was used to reduce bacterial burden and healing time in burn injuries. MATERIALS & METHODS:Ethosomal formulations were characterized for their size, ζ-potential, morphology, drug encapsulation efficiency and in vitro release kinetics of SSD. RESULTS: The optimized nanoethosomal suspension with a size of 206.7 ± 1.18, and ζ-potential value of -67.3 ± 0.45 mV exhibited a high SSD encapsulation efficiency (92.03 ± 0.79%). Results of antimicrobial tests indicated SSD-loaded ethosome formulation led to a significant reduction of colony number. Histopathological results demonstrated a wound contraction rate of 96.83% for the group treated with SSDethosomal gel while untreated group showed 59.41%. CONCLUSION: The SSD ethogels promotes the therapeutic effect of SSD for burn treatment.
Entities:
Keywords:
ethogels; ethosomes; in vivo histopathology; second-degree burns; silver sulfadiazine
Authors: Mohammad Khaledian; Mohammad Sadegh Nourbakhsh; Reza Saber; Hadi Hashemzadeh; Mohammad Hasan Darvishi Journal: Int J Nanomedicine Date: 2020-08-18