| Literature DB >> 29949208 |
Yuhua Ru1,2, Jia Chen1,2, Depei Wu1,2.
Abstract
Epstein-Barr virus (EBV) viremia and post-transplant lymphoproliferative disease (PTLD) are severe complications after hematopoietic stem cell transplantation (HSCT). A series of risk factors have been found to predict EBV viremia and PTLD, including the T-cell depletion, reduced intensity conditioning, and alternative donor. The rituximab pre-emptive therapy could improve PTLD prognosis significantly, but the trigger of initiating rituximab pre-emptive therapy has not been well established. Additionally, EBV-specific cytotoxic T cell (CTL) is a promising approach to treat EBV-PTLD.Entities:
Keywords: EB virus; hematopoietic stem cell transplantation; lymphoproliferative disease
Mesh:
Substances:
Year: 2018 PMID: 29949208 DOI: 10.1111/ejh.13131
Source DB: PubMed Journal: Eur J Haematol ISSN: 0902-4441 Impact factor: 2.997