| Literature DB >> 29948819 |
Ryuta Shigefuku1, Tsunamasa Watanabe2, Takuro Mizukami3, Kotaro Matsunaga1, Nobuhiro Hattori1, Takuya Ehira1, Tatsuya Suzuki1, Hiroyasu Nakano1, Yoshinori Sato1, Yasumasa Matsuo1, Kazunari Nakahara1, Hiroki Ikeda1, Nobuyuki Matsumoto1, Takashi Tsuda3, Masafumi Katayama4, Satoshi Koizumi4, Chiaki Okuse5, Michihiro Suzuki5, Takehito Otsubo4, Takako Eguchi Nakajima3, Hiroshi Yasuda1, Fumio Itoh1.
Abstract
Oxaliplatin, a chemotherapeutic agent for colorectal cancer, has been associated with pathological evidence of sinusoidal endothelial injury in the liver. However, esophagogastric varices are a poorly recognized outcome of oxaliplatin-based chemotherapy. We report a 78-year-old man, whose past history of colon cancer was resection and treatment with mFOLFOX6 for 20 weeks, as adjuvant chemotherapy. After 3.5-year follow-up of the oxaliplatin-based chemotherapy, he was diagnosed with esophageal varices without liver dysfunction, indicating that the hepatotoxicity caused by oxaliplatin could be prolonged after its administration. Patients who have received oxaliplatin-based chemotherapy should be followed up carefully over the long term.Entities:
Keywords: Esophagogastric varices; Hepatotoxicity; Non-cirrhosis; Oxaliplatin; Sinusoidal obstruction syndrome (SOS)
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Year: 2018 PMID： 29948819 DOI： 10.1007/s12328-018-0873-1
Source DB: PubMed Journal: Clin J Gastroenterol ISSN： 1865-7265