Yuhong Peng1,2,3, Chao Zou2, Yangzi Qiao2, Changjun Tie2, Qian Wan2, Rui Jiang2,4, Chuanli Cheng2,4, Dong Liang2, Hairong Zheng2, Faqi Li5,6, Xin Liu7,8. 1. State Key Laboratory of Ultrasound Engineering in Medicine, Chongqing Key Laboratory of Biomedical Engineering, Co-Founded by Chongqing and the Ministry of Science and Technology, College of Biomedical Engineering, Chongqing Medical University, 153 Box, 1 Yixueyuan Road, Yuzhong District, Chongqing, 400016, China. 2. Paul C Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, 1068 Xueyuan Blvd, Nanshan District, Shenzhen, 518055, Guangdong, China. 3. Chongqing Collaborative Innovation Center for Minimally-invasive and Noninvasive Medicine, Chongqing, 400016, China. 4. Shenzhen College of Advanced Technology, University of Chinese Academy of Sciences, Shenzhen, Guangdong, 518055, China. 5. State Key Laboratory of Ultrasound Engineering in Medicine, Chongqing Key Laboratory of Biomedical Engineering, Co-Founded by Chongqing and the Ministry of Science and Technology, College of Biomedical Engineering, Chongqing Medical University, 153 Box, 1 Yixueyuan Road, Yuzhong District, Chongqing, 400016, China. lifaqi70@163.com. 6. Chongqing Collaborative Innovation Center for Minimally-invasive and Noninvasive Medicine, Chongqing, 400016, China. lifaqi70@163.com. 7. Paul C Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, 1068 Xueyuan Blvd, Nanshan District, Shenzhen, 518055, Guangdong, China. xin.liu@siat.ac.cn. 8. Chongqing Collaborative Innovation Center for Minimally-invasive and Noninvasive Medicine, Chongqing, 400016, China. xin.liu@siat.ac.cn.
Abstract
PURPOSE: Real-time monitoring is important for the safety and effectiveness of high-intensity focused ultrasound (HIFU) therapy. Magnetic resonance imaging is the preferred imaging modality for HIFU monitoring, with its unique capability of temperature imaging. For real-time temperature imaging, higher temporal resolution and larger spatial coverage are needed. In this study, a sequence based on the echo-shifted RF-spoiled gradient echo (GRE) with simultaneous multi-slice (SMS) imaging was designed for fast temperature imaging. METHODS: A phantom experiment was conducted to evaluate the accuracy of the echo-shifted sequence using a fluorescent fiber thermometer as reference. The temperature uncertainty of the echo-shifted sequence was compared with the traditional GRE sequence at room temperature through the ex vivo porcine muscle. Finally, the ex vivo porcine liver tissue experiment using HIFU heating was performed to demonstrate that the spatial coverage was increased without decreasing temporal resolution. RESULTS: The echo-shifted sequence had a better temperature uncertainty performance compared with the traditional GRE sequence with the same temporal resolution. The ex vivo heating experiment confirmed that by combining the SMS technique and echo-shifted sequence, the spatial coverage was increased without decreasing the temporal resolution while maintaining high temperature measurement precision. CONCLUSION: The proposed technique was validated as an effective real-time method for monitoring HIFU therapy.
PURPOSE: Real-time monitoring is important for the safety and effectiveness of high-intensity focused ultrasound (HIFU) therapy. Magnetic resonance imaging is the preferred imaging modality for HIFU monitoring, with its unique capability of temperature imaging. For real-time temperature imaging, higher temporal resolution and larger spatial coverage are needed. In this study, a sequence based on the echo-shifted RF-spoiled gradient echo (GRE) with simultaneous multi-slice (SMS) imaging was designed for fast temperature imaging. METHODS: A phantom experiment was conducted to evaluate the accuracy of the echo-shifted sequence using a fluorescent fiber thermometer as reference. The temperature uncertainty of the echo-shifted sequence was compared with the traditional GRE sequence at room temperature through the ex vivo porcine muscle. Finally, the ex vivo porcine liver tissue experiment using HIFU heating was performed to demonstrate that the spatial coverage was increased without decreasing temporal resolution. RESULTS: The echo-shifted sequence had a better temperature uncertainty performance compared with the traditional GRE sequence with the same temporal resolution. The ex vivo heating experiment confirmed that by combining the SMS technique and echo-shifted sequence, the spatial coverage was increased without decreasing the temporal resolution while maintaining high temperature measurement precision. CONCLUSION: The proposed technique was validated as an effective real-time method for monitoring HIFU therapy.
Keywords:
Echo-shifted sequence; Magnetic resonance imaging; Simultaneous multi-slice imaging; Thermometry
Authors: Felix A Breuer; Martin Blaimer; Robin M Heidemann; Matthias F Mueller; Mark A Griswold; Peter M Jakob Journal: Magn Reson Med Date: 2005-03 Impact factor: 4.668
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