Literature DB >> 2994782

Platelet membrane topography: colocalization of thrombospondin and fibrinogen with the glycoprotein IIb-IIIa complex.

A S Asch, L L Leung, M J Polley, R L Nachman.   

Abstract

The distribution of platelet thrombospondin (TSP), fibrinogen, and glycoproteins IIb-IIIa (GPIIb-IIIa) and GPIb were studied in resting and activated human platelets using frozen thin-section immunoelectron microscopy. In resting platelets, TSP and fibrinogen were found within alpha granules and not on the platelet surface. In unstimulated platelets, GPIIb-IIIa and GPIb were distributed diffusely over the platelet membrane as well as within the body of the platelets. Upon thrombin or A23187 stimulation, TSP, fibrinogen, and GPIIb-IIIa colocalized on the platelet membrane and the canalicular system as well as on pseudopodia and between adherent platelets. GPIb distribution was unchanged by platelet activation. The findings support the hypothesis that a macromolecular complex of TSP-fibrinogen and GPIIb-IIIa forms on the activated platelet membrane.

Entities:  

Mesh：

Substances：

Year:  1985        PMID： 2994782

Source DB:  PubMed          Journal:  Blood        ISSN： 0006-4971            Impact factor:   22.113


  13 in total

Review 1.  Thrombospondin as a mediator of cancer cell adhesion in metastasis.

Authors:  D A Walz
Journal:  Cancer Metastasis Rev       Date:  1992-11       Impact factor: 9.264

2.  Platelet morphologic changes and fibrinogen receptor localization. Initial responses in ADP-activated human platelets.

Authors:  M E Hensler; M Frojmovic; R G Taylor; R R Hantgan; J C Lewis
Journal:  Am J Pathol       Date:  1992-09       Impact factor: 4.307

3.  Immunoelectron-microscopic studies of human platelet thrombospondin, von Willebrand factor, and fibrinogen redistribution during clot formation.

Authors:  S C Watkins; V Raso; H S Slayter
Journal:  Histochem J       Date:  1990-09

4.  Dynamic redistribution of major platelet surface receptors after contact-induced platelet activation and spreading. An immunoelectron microscopy study.

Authors:  N Kieffer; J Guichard; J Breton-Gorius
Journal:  Am J Pathol       Date:  1992-01       Impact factor: 4.307

5.  Thrombospondin-1 is required for normal murine pulmonary homeostasis and its absence causes pneumonia.

Authors:  J Lawler; M Sunday; V Thibert; M Duquette; E L George; H Rayburn; R O Hynes
Journal:  J Clin Invest       Date:  1998-03-01       Impact factor: 14.808

6.  Identification of a new class of inducible receptors on platelets. Thrombospondin interacts with platelets via a GPIIb-IIIa-independent mechanism.

Authors:  M L Aiken; M H Ginsberg; E F Plow
Journal:  J Clin Invest       Date:  1986-12       Impact factor: 14.808

7.  Platelet storage results in a redistribution of glycoprotein Ib molecules. Evidence for a large intraplatelet pool of glycoprotein Ib.

Authors:  A D Michelson; B Adelman; M R Barnard; E Carroll; R I Handin
Journal:  J Clin Invest       Date:  1988-06       Impact factor: 14.808

8.  Localization of adhesive proteins in two newly subdivided zones in electron-lucent matrix of human platelet alpha-granules.

Authors:  H Suzuki; Y Katagiri; S Tsukita; K Tanoue; H Yamazaki
Journal:  Histochemistry       Date:  1990

9.  Fibrinogen and glycoprotein IIb/IIIa localization during platelet adhesion. Localization to the granulomere and at sites of platelet interaction.

Authors:  J C Lewis; R R Hantgan; S C Stevenson; T Thornburg; N Kieffer; J Guichard; J Breton-Gorius
Journal:  Am J Pathol       Date:  1990-01       Impact factor: 4.307

10.  Dynamic measurements of the platelet membrane glycoprotein IIb-IIIa receptor for fibrinogen by flow cytometry. I. Methodology, theory and results for two distinct activators.

Authors:  M Frojmovic; T Wong; T van de Ven
Journal:  Biophys J       Date:  1991-04       Impact factor: 4.033
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.