K Herlofson1, C J Heijnen2, J Lange3, G Alves3,4, O-B Tysnes5,6, J H Friedman7, C P Fagundes8,9. 1. Department of Neurology, Sorlandet Hospital, Arendal, Norway. 2. Department of Symptom Research, M. D. Anderson Cancer Center, Houston, TX, USA. 3. The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway. 4. Department of Mathematics and Natural Sciences, University of Stavanger, Stavanger, Norway. 5. Department of Neurology, Haukeland University Hospital, Department of Clinical Medicine, Bergen, Norway. 6. Department of Clinical Medicine, Haukeland University Hospital, Bergen, Norway. 7. Butler Hospital, Warren Alpert Medical School of Brown University, Providence, RI, USA. 8. Department of Psychology, Rice University and MD Anderson Cancer Center, Houston, TX, USA. 9. Department of Behavioral Science, Rice University and MD Anderson Cancer Center, Houston, TX, USA.
Abstract
OBJECTIVES: Parkinson's disease (PD)-related fatigue is a significant clinical problem, and the pathological processes that cause fatigue remain unknown. The aim of the present study was to explore the possible association of peripheral inflammation markers and fatigue in PD. MATERIALS & METHODS: We included 47 drug naïve, newly diagnosed PD patients with low (≤3.0) or high (>5.5) fatigue levels as evaluated by the Fatigue Severity Scale (FSS). Strict diagnostic criteria were applied for inclusion. Patients with possible confounding causes for fatigue were excluded. Serum concentrations of a panel of inflammatory markers (IL-8, TNF-α, MCP1, MIP-1β, IL-6, IL-6R, p-selectin, E-selectin-1, ICAM, VCAM-1, CCL5, IL1-Ra, and TNFR1) were measured using ELISA technology in PD patients with and without fatigue to assess the potential relationships of fatigue in newly diagnosed, treatment-naïve patients. RESULTS: Fatigued PD patients had significantly higher levels of the IL-1 receptor antagonist (IL1-Ra) (1790 pg/mL (SD1007) vs 1262 pg/mL (SD379)) and of the adhesion molecule VCAM 1 (1071 ng/mL (SD276) vs 895 ng/mL (SD229)) than non-fatigued patients. A binary logistic regression model, including high or low FSS score as the dependent variable and UPDRS motor score, MADRS, MMSE, ESS, and IL1-Ra/VCAM-1 as independent variables, showed a significant effect both for IL1-Ra and VCAM-1. CONCLUSIONS: Higher serum levels of the inflammatory molecules IL1-Ra and VCAM-1 were associated with higher fatigue levels in patients with newly diagnosed, drug-naïve PD. These findings highlight an altered immune response as a potential contributor to PD-related fatigue, from the earliest clinical stages of the disease.
OBJECTIVES:Parkinson's disease (PD)-related fatigue is a significant clinical problem, and the pathological processes that cause fatigue remain unknown. The aim of the present study was to explore the possible association of peripheral inflammation markers and fatigue in PD. MATERIALS & METHODS: We included 47 drug naïve, newly diagnosed PDpatients with low (≤3.0) or high (>5.5) fatigue levels as evaluated by the Fatigue Severity Scale (FSS). Strict diagnostic criteria were applied for inclusion. Patients with possible confounding causes for fatigue were excluded. Serum concentrations of a panel of inflammatory markers (IL-8, TNF-α, MCP1, MIP-1β, IL-6, IL-6R, p-selectin, E-selectin-1, ICAM, VCAM-1, CCL5, IL1-Ra, and TNFR1) were measured using ELISA technology in PDpatients with and without fatigue to assess the potential relationships of fatigue in newly diagnosed, treatment-naïve patients. RESULTS:FatiguedPDpatients had significantly higher levels of the IL-1 receptor antagonist (IL1-Ra) (1790 pg/mL (SD1007) vs 1262 pg/mL (SD379)) and of the adhesion molecule VCAM 1 (1071 ng/mL (SD276) vs 895 ng/mL (SD229)) than non-fatiguedpatients. A binary logistic regression model, including high or low FSS score as the dependent variable and UPDRS motor score, MADRS, MMSE, ESS, and IL1-Ra/VCAM-1 as independent variables, showed a significant effect both for IL1-Ra and VCAM-1. CONCLUSIONS: Higher serum levels of the inflammatory molecules IL1-Ra and VCAM-1 were associated with higher fatigue levels in patients with newly diagnosed, drug-naïve PD. These findings highlight an altered immune response as a potential contributor to PD-related fatigue, from the earliest clinical stages of the disease.
Authors: Amanda V Sardeli; Arthur F Gáspari; Wellington M Dos Santos; Amanda A de Araujo; Kátia de Angelis; Lilian O Mariano; Cláudia R Cavaglieri; Bo Fernhall; Mara Patrícia T Chacon-Mikahil Journal: Int J Environ Res Public Health Date: 2022-09-04 Impact factor: 4.614
Authors: Santiago R Unda; Aldana M Antoniazzi; David J Altschul; Roberta Marongiu Journal: Dement Geriatr Cogn Disord Date: 2021-05-31 Impact factor: 2.959