Literature DB >> 2994652

Angiotensin II and phorbol ester enhance isoproterenol- and vasoactive intestinal peptide (VIP)-induced cyclic AMP accumulation in vascular smooth muscle cells.

T Nabika, Y Nara, Y Yamori, W Lovenberg, J Endo.   

Abstract

The importance of Ca2+ and cAMP in the regulation of cellular functions has been well demonstrated. We studied the effect of angiotensin II (AII), a potent Ca2+-mobilizing hormone, on cAMP accumulation induced by isoproterenol (ISO) and vasoactive intestinal peptide (VIP) in cultured vascular smooth muscle cells (VSMC). Although the addition of AII alone caused little increase of cAMP, it enhanced ISO- and VIP-induced cAMP accumulations in a dose-dependent manner. This enhancement was mimicked by tumor-promoting phorbol ester but not by Ca2+ ionophore. This observation suggested that AII enhanced agonist-induced cAMP accumulation through the activation of protein kinase C in VSMC.

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Year:  1985        PMID： 2994652     DOI： 10.1016/0006-291x(85)91765-6

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  10 in total

1.  The phorbol ester TPA stimulates the expression of functional beta-adrenoceptors in human T lymphoblasts Molt 3.

Authors:  P Robberecht; P De Neef; L Buscail; J Christophe
Journal:  Biochem J       Date:  1989-08-01       Impact factor: 3.857

2.  Phorbol-12,13-dibutyrate enhances the cyclic AMP accumulation in rat hippocampal slices induced by adenosine analogues.

Authors:  C Nordstedt; B B Fredholm
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-02       Impact factor: 3.000

Review 3.  Melatonin biosynthesis in the mammalian pineal gland.

Authors:  D Sugden
Journal:  Experientia       Date:  1989-10-15

Review 4.  Beta-adrenergic receptor-coupled adenylate cyclase. Biochemical mechanisms of regulation.

Authors:  D R Sibley; R J Lefkowitz
Journal:  Mol Neurobiol       Date:  1987 Spring-Summer       Impact factor: 5.590

5.  Mapping second messenger systems in the brain: differential localizations of adenylate cyclase and protein kinase C.

Authors:  P F Worley; J M Baraban; E B De Souza; S H Snyder
Journal:  Proc Natl Acad Sci U S A       Date:  1986-06       Impact factor: 11.205

6.  Endothelin-1 stimulates contraction of rat glomerular mesangial cells and potentiates beta-adrenergic-mediated cyclic adenosine monophosphate accumulation.

Authors:  M S Simonson; M J Dunn
Journal:  J Clin Invest       Date:  1990-03       Impact factor: 14.808

7.  BK1 and BK2 bradykinin receptors in the rat duodenum smooth muscle.

Authors:  T Feres; A C Paiva; T B Paiva
Journal:  Br J Pharmacol       Date:  1992-12       Impact factor: 8.739

8.  Morphological alterations in endothelial cells from human aorta and umbilical vein induced by forskolin and phorbol 12-myristate 13-acetate: a synergistic action of adenylate cyclase and protein kinase C activators.

Authors:  A S Antonov; M E Lukashev; Y A Romanov; V A Tkachuk; V S Repin; V N Smirnov
Journal:  Proc Natl Acad Sci U S A       Date:  1986-12       Impact factor: 11.205

9.  Activation of protein kinase C by elevation of glucose concentration: proposal for a mechanism in the development of diabetic vascular complications.

Authors:  T S Lee; K A Saltsman; H Ohashi; G L King
Journal:  Proc Natl Acad Sci U S A       Date:  1989-07       Impact factor: 11.205

10.  Biochemical and molecular aspects of vascular adrenergic regulation of blood pressure in the elderly.

Authors:  William E Schutzer; Scott L Mader
Journal:  Int J Hypertens       Date:  2011-09-22       Impact factor: 2.420
  10 in total

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